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PRE9 proteasome core particle subunit alpha 3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853036, updated on 10-Mar-2023

Summary

Gene symbol
PRE9
Gene description
proteasome core particle subunit alpha 3
Primary source
SGD:S000003367
Locus tag
YGR135W
See related
AllianceGenome:SGD:S000003367
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable threonine-type endopeptidase activity. Involved in proteasomal ubiquitin-independent protein catabolic process; proteasome core complex assembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in proteasome storage granule. Part of proteasome core complex, alpha-subunit complex. Orthologous to human PSMA4 (proteasome 20S subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See PRE9 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (761392..762168)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene E2 ubiquitin-protein ligase peroxin 4 Neighboring gene CCR4-NOT core subunit CAF130 Neighboring gene Lsb1p Neighboring gene spermine transporter

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the PRE9 gene: The PRE9 gene is conserved in human, chimpanzee, Rhesus monkey, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear outer membrane-endoplasmic reticulum membrane network IC
Inferred by Curator
more info
PubMed 
located_in nuclear outer membrane-endoplasmic reticulum membrane network IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome core complex, alpha-subunit complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex, alpha-subunit complex IEA
Inferred from Electronic Annotation
more info
 
located_in proteasome storage granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in proteasome storage granule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
proteasome core particle subunit alpha 3
NP_011651.3
  • Alpha 3 subunit of the 20S proteasome; the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    761392..762168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181264.3NP_011651.3  TPA: proteasome core particle subunit alpha 3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011651.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUR7, P23638
    UniProtKB/TrEMBL
    A0A0L8VQ09, A0A6A5PXC6, A0A6C1DS11, A6ZUE9, B3LI93, B5VJ80, C7GUG0, G2WEL7, N1P9W9
    Conserved Domains (1) summary
    cd03752
    Location:4216
    proteasome_alpha_type_4; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...