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TPC1 thiamine transporter TPC1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852988, updated on 18-Sep-2024

Summary

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Official Symbol
TPC1
Official Full Name
thiamine transporter TPC1
Primary source
SGD:S000003328
Locus tag
YGR096W
See related
AllianceGenome:SGD:S000003328; FungiDB:YGR096W; VEuPathDB:YGR096W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables thiamine pyrophosphate transmembrane transporter activity. Involved in mitochondrial thiamine pyrophosphate transmembrane transport. Is integral component of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in inherited metabolic disorder and microcephaly. Orthologous to human SLC25A19 (solute carrier family 25 member 19). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (676621..677565)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene valine--tRNA ligase Neighboring gene exosome non-catalytic core subunit RRP46 Neighboring gene Ask10p Neighboring gene separase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and reconstitution of the yeast mitochondrial transporter for thiamine pyrophosphate. Marobbio CM, et al. EMBO J, 2002 Nov 1. PMID 12411483, Free PMC Article
  2. Thiamine increases the resistance of baker's yeast Saccharomyces cerevisiae against oxidative, osmotic and thermal stress, through mechanisms partly independent of thiamine diphosphate-bound enzymes. Wolak N, et al. FEMS Yeast Res, 2014 Dec. PMID 25331172
  3. Identification of mitochondrial thiamin diphosphate carriers from Arabidopsis and maize. Frelin O, et al. Funct Integr Genomics, 2012 Jun. PMID 22426856
  4. The biochemical properties of the mitochondrial thiamine pyrophosphate carrier from Drosophila melanogaster. Iacopetta D, et al. FEBS J, 2010 Mar. PMID 20121944
  5. The yeast mitochondrial transport proteins: new sequences and consensus residues, lack of direct relation between consensus residues and transmembrane helices, expression patterns of the transport protein genes, and protein-protein interactions with other proteins. Belenkiy R, et al. Biochim Biophys Acta, 2000 Jul 31. PMID 10930523

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables thiamine pyrophosphate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thiamine pyrophosphate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables thiamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial thiamine pyrophosphate transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial thiamine pyrophosphate transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in thiamine pyrophosphate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
thiamine transporter TPC1
NP_011610.3
  • Mitochondrial membrane transporter; mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    676621..677565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181225.3 → NP_011610.3  TPA: thiamine transporter TPC1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011610.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZV78, D6VUM8, P53257, Q6B1H1
    UniProtKB/TrEMBL
    B3LID0, B5VJ43, C7GWW7, C8Z8Z0, N1P9W1
    Conserved Domains (2) summary
    PTZ00169
    Location:21 → 285
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:16 → 105
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53257.1

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