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SLX9 Slx9p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852972, updated on 18-Sep-2024

Summary

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Official Symbol
SLX9
Official Full Name
Slx9p
Primary source
SGD:S000003313
Locus tag
YGR081C
See related
AllianceGenome:SGD:S000003313; FungiDB:YGR081C; VEuPathDB:YGR081C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables G-quadruplex DNA binding activity. Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal small subunit export from nucleus. Located in nucleolus. Part of 90S preribosome and preribosome, small subunit precursor. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (643148..643780, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Twf1p Neighboring gene Tom20p Neighboring gene translation initiation factor eIF2B subunit delta

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Slx9p facilitates efficient ITS1 processing of pre-rRNA in Saccharomyces cerevisiae. Bax R, et al. RNA, 2006 Nov. PMID 17018574, Free PMC Article
  2. A Novel G-Quadruplex Binding Protein in Yeast-Slx9. Götz S, et al. Molecules, 2019 May 7. PMID 31067825, Free PMC Article
  3. A mutant plasma membrane protein is stabilized upon loss of Yvh1, a novel ribosome assembly factor. Liu Y, et al. Genetics, 2009 Mar. PMID 19114459, Free PMC Article
  4. Genome-wide mRNA surveillance is coupled to mRNA export. Hieronymus H, et al. Genes Dev, 2004 Nov 1. PMID 15489286, Free PMC Article
  5. Genetic interactions show the importance of rRNA modification machinery for the role of Rps15p during ribosome biogenesis in S. cerevisiae. Bellemer C, et al. PLoS One, 2010 May 3. PMID 20454621, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables G-quadruplex DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
Inferred from Electronic Annotation
more info
  
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal small subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 90S preribosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of 90S preribosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus HDA PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, small subunit precursor IDA
Inferred from Direct Assay
more info
 PubMed 
part_of preribosome, small subunit precursor IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Slx9p
NP_011595.3
  • Nuclear export receptor for exportin Crm1p; required for pre-rRNA processing and nuclear export of pre-40S pre-ribosomal particles; associates with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; binds G-quadruplex (G4) structures in DNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    643148..643780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181210.3 → NP_011595.3  TPA: Slx9p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011595.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZV63, P53251
    UniProtKB/TrEMBL
    B3LIE5, B5VJ25, C7GXR0, C8Z8X5
    Conserved Domains (1) summary
    pfam15341
    Location:47 → 206
    SLX9; Ribosome biogenesis protein SLX9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53251.1

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