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PARG poly(ADP-ribose) glycohydrolase [ Homo sapiens (human) ]

Gene ID: 8505, updated on 26-Jul-2021

Summary

Official Symbol
PARGprovided by HGNC
Official Full Name
poly(ADP-ribose) glycohydrolaseprovided by HGNC
Primary source
HGNC:HGNC:8605
See related
Ensembl:ENSG00000227345 MIM:603501
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PARG99
Summary
Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Expression
Ubiquitous expression in kidney (RPKM 6.5), testis (RPKM 6.1) and 25 other tissues See more
Orthologs
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Genomic context

See PARG in Genome Data Viewer
Location:
10q11.23
Exon count:
21
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (49818279..49942027, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (51026325..51371371, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 6 pseudogene 6 Neighboring gene ribosomal protein L21 pseudogene 89 Neighboring gene Sharpr-MPRA regulatory region 10647 Neighboring gene ribosomal protein L35a pseudogene 24 Neighboring gene TIMM23B-AGAP6 readthrough (NMD candidate) Neighboring gene translocase of inner mitochondrial membrane 23 homolog B Neighboring gene small nucleolar RNA, H/ACA box 74C-2 Neighboring gene RNA, 5S ribosomal pseudogene 317

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ54459, FLJ60257, FLJ60456

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables poly(ADP-ribose) glycohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables poly(ADP-ribose) glycohydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables poly(ADP-ribose) glycohydrolase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ATP generation from poly-ADP-D-ribose IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ATP generation from poly-ADP-D-ribose IDA
Inferred from Direct Assay
more info
PubMed 
involved_in base-excision repair, gap-filling TAS
Traceable Author Statement
more info
 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleotide-sugar metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of histone modification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
poly(ADP-ribose) glycohydrolase
Names
mitochondrial poly(ADP-ribose) glycohydrolase
NP_001290415.1
NP_001290416.1
NP_001290418.1
NP_001311310.1
NP_003622.2
XP_011538607.1
XP_011538610.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303486.3NP_001290415.1  poly(ADP-ribose) glycohydrolase isoform b

    See identical proteins and their annotated locations for NP_001290415.1

    Status: REVIEWED

    Source sequence(s)
    AC069546, AL731572, FP565721
    UniProtKB/Swiss-Prot
    Q86W56
    Conserved Domains (1) summary
    pfam05028
    Location:499827
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
  2. NM_001303487.3NP_001290416.1  poly(ADP-ribose) glycohydrolase isoform c

    See identical proteins and their annotated locations for NP_001290416.1

    Status: REVIEWED

    Source sequence(s)
    AC069546, AL731572, FP565721
    UniProtKB/Swiss-Prot
    Q86W56
    Conserved Domains (1) summary
    pfam05028
    Location:473801
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
  3. NM_001303489.3NP_001290418.1  poly(ADP-ribose) glycohydrolase isoform d

    Status: REVIEWED

    Source sequence(s)
    AC069546, AL731572, FP565721
    Conserved Domains (1) summary
    pfam05028
    Location:167495
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
  4. NM_001324381.3NP_001311310.1  poly(ADP-ribose) glycohydrolase isoform b

    Status: REVIEWED

    Source sequence(s)
    AC069546, AL731572, FP565721
    UniProtKB/Swiss-Prot
    Q86W56
    Conserved Domains (1) summary
    pfam05028
    Location:499827
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
  5. NM_003631.5NP_003622.2  poly(ADP-ribose) glycohydrolase isoform a

    See identical proteins and their annotated locations for NP_003622.2

    Status: REVIEWED

    Source sequence(s)
    AC069546, AL731572, FP565721
    Consensus CDS
    CCDS73130.1
    UniProtKB/Swiss-Prot
    Q86W56
    Related
    ENSP00000484285.1, ENST00000616448.2
    Conserved Domains (1) summary
    pfam05028
    Location:581909
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

RNA

  1. NR_130168.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069546, AL731572, FP565721
  2. NR_130169.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069546, AL731572, FP565721
  3. NR_136752.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069546, AL731572, FP565721
  4. NR_136753.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069546, AL731572, FP565721
  5. NR_136754.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069546, AL731572, FP565721
    Related
    ENST00000614063.4
  6. NR_136755.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069546, AL731572, FP565721
  7. NR_136756.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069546, AL731572, FP565721

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    49818279..49942027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540305.1XP_011538607.1  poly(ADP-ribose) glycohydrolase isoform X1

    Conserved Domains (1) summary
    pfam05028
    Location:540868
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
  2. XM_011540308.2XP_011538610.1  poly(ADP-ribose) glycohydrolase isoform X2

    Conserved Domains (1) summary
    pfam05028
    Location:581675
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

RNA

  1. XR_001747247.1 RNA Sequence

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