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Parg poly (ADP-ribose) glycohydrolase [ Mus musculus (house mouse) ]

Gene ID: 26430, updated on 8-Feb-2024

Summary

Official Symbol
Pargprovided by MGI
Official Full Name
poly (ADP-ribose) glycohydrolaseprovided by MGI
Primary source
MGI:MGI:1347094
See related
Ensembl:ENSMUSG00000021911 AllianceGenome:MGI:1347094
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables poly(ADP-ribose) glycohydrolase activity. Acts upstream of or within cellular response to DNA damage stimulus and detection of bacterium. Located in cytosol and nucleus. Is expressed in several structures, including adrenal gland; brain; cardiovascular system; genitourinary system; and gut. Orthologous to several human genes including BPHL (biphenyl hydrolase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.1), CNS E14 (RPKM 3.9) and 28 other tissues See more
Orthologs
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Genomic context

See Parg in Genome Data Viewer
Location:
14 19.4 cM; 14 B
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31923900..32020671)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32201930..32298714)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 4 Neighboring gene STARR-seq mESC enhancer starr_36340 Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene predicted gene, 23946 Neighboring gene STARR-positive B cell enhancer mm9_chr14:33042212-33042513 Neighboring gene tetratricopeptide repeat domain 35 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36341 Neighboring gene predicted gene, 48914 Neighboring gene oxoglutarate dehydrogenase-like Neighboring gene predicted gene, 52134 Neighboring gene RIKEN cDNA 1700024G13 gene Neighboring gene STARR-seq mESC enhancer starr_36344

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables poly(ADP-ribose) glycohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables poly(ADP-ribose) glycohydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables poly(ADP-ribose) glycohydrolase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ATP generation from poly-ADP-D-ribose IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ATP generation from poly-ADP-D-ribose ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within detection of bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleotide-sugar metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of DNA repair IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
poly(ADP-ribose) glycohydrolase
Names
cytosolic poly(ADP-ribose) glycohydrolase
NP_001346844.1
NP_001361150.1
NP_036090.2
XP_030103682.1
XP_030103683.1
XP_036014496.1
XP_036014497.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359915.1NP_001346844.1  poly(ADP-ribose) glycohydrolase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC167565, AI450246, AK080306, BC053037, BC059827
    UniProtKB/Swiss-Prot
    O88622, Q80YQ6, Q8CB72
    Conserved Domains (1) summary
    pfam05028
    Location:491816
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
  2. NM_001374221.1NP_001361150.1  poly(ADP-ribose) glycohydrolase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154532, AC167565
    UniProtKB/Swiss-Prot
    O88622, Q80YQ6, Q8CB72
    Conserved Domains (1) summary
    pfam05028
    Location:468793
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
  3. NM_011960.3NP_036090.2  poly(ADP-ribose) glycohydrolase isoform 1

    See identical proteins and their annotated locations for NP_036090.2

    Status: VALIDATED

    Source sequence(s)
    AC167565, AI450246, BC053037, BC059827
    Consensus CDS
    CCDS36865.1
    UniProtKB/Swiss-Prot
    O88622, Q80YQ6, Q8CB72
    UniProtKB/TrEMBL
    G3X8U8
    Related
    ENSMUSP00000022470.9, ENSMUST00000022470.15
    Conserved Domains (1) summary
    pfam05028
    Location:574902
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    31923900..32020671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158604.1XP_036014497.1  poly(ADP-ribose) glycohydrolase isoform X3

    UniProtKB/TrEMBL
    A0A2I3BRU5
    Related
    ENSMUSP00000154704.2, ENSMUST00000164137.8
    Conserved Domains (2) summary
    pfam05028
    Location:574682
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
    NF033845
    Location:171346
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
  2. XM_036158603.1XP_036014496.1  poly(ADP-ribose) glycohydrolase isoform X1

    UniProtKB/Swiss-Prot
    O88622, Q80YQ6, Q8CB72
    Conserved Domains (1) summary
    pfam05028
    Location:491816
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
  3. XM_030247822.2XP_030103682.1  poly(ADP-ribose) glycohydrolase isoform X1

    UniProtKB/Swiss-Prot
    O88622, Q80YQ6, Q8CB72
    Conserved Domains (1) summary
    pfam05028
    Location:491816
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
  4. XM_030247823.2XP_030103683.1  poly(ADP-ribose) glycohydrolase isoform X2

    UniProtKB/Swiss-Prot
    O88622, Q80YQ6, Q8CB72
    Conserved Domains (1) summary
    pfam05028
    Location:468793
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)