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MFSD5 major facilitator superfamily domain containing 5 [ Homo sapiens (human) ]

Gene ID: 84975, updated on 7-Jun-2020

Summary

Official Symbol
MFSD5provided by HGNC
Official Full Name
major facilitator superfamily domain containing 5provided by HGNC
Primary source
HGNC:HGNC:28156
See related
Ensembl:ENSG00000182544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hsMOT2
Expression
Ubiquitous expression in skin (RPKM 12.9), esophagus (RPKM 11.1) and 25 other tissues See more
Orthologs

Genomic context

See MFSD5 in Genome Data Viewer
Location:
12q13.13
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (53251251..53254406)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53645035..53648190)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 740 Neighboring gene integrin subunit beta 7 Neighboring gene retinoic acid receptor gamma Neighboring gene extra spindle pole bodies like 1, separase Neighboring gene MYG1 antisense RNA 1 Neighboring gene prefoldin subunit 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC11308

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molybdate ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
molybdate ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
molybdate-anion transporter
Names
major facilitator superfamily domain-containing protein 5
molybdate transporter 2 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170790.1NP_001164261.1  molybdate-anion transporter isoform 1

    See identical proteins and their annotated locations for NP_001164261.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK097576, BC007703, BC067795, DA565785
    Consensus CDS
    CCDS53796.1
    UniProtKB/Swiss-Prot
    Q6N075
    Related
    ENSP00000442688.1, ENST00000534842.1
    Conserved Domains (2) summary
    pfam07690
    Location:155488
    MFS_1; Major Facilitator Superfamily
    cl21472
    Location:113435
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  2. NM_032889.5NP_116278.3  molybdate-anion transporter isoform 2 precursor

    See identical proteins and their annotated locations for NP_116278.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK074684, BC067795, DA428788, DA695979
    Consensus CDS
    CCDS8851.1
    UniProtKB/Swiss-Prot
    Q6N075
    Related
    ENSP00000332624.4, ENST00000329548.4
    Conserved Domains (1) summary
    cl21472
    Location:6328
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    53251251..53254406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269197.1XP_005269254.1  molybdate-anion transporter isoform X1

    See identical proteins and their annotated locations for XP_005269254.1

    UniProtKB/Swiss-Prot
    Q6N075
    Conserved Domains (2) summary
    pfam07690
    Location:155488
    MFS_1; Major Facilitator Superfamily
    cl21472
    Location:113435
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  2. XM_005269198.4XP_005269255.1  molybdate-anion transporter isoform X2

    See identical proteins and their annotated locations for XP_005269255.1

    UniProtKB/Swiss-Prot
    Q6N075
    Conserved Domains (1) summary
    cl21472
    Location:6328
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
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