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ALG10 ALG10 alpha-1,2-glucosyltransferase [ Homo sapiens (human) ]

Gene ID: 84920, updated on 17-Jun-2019

Summary

Official Symbol
ALG10provided by HGNC
Official Full Name
ALG10 alpha-1,2-glucosyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:23162
See related
Ensembl:ENSG00000139133 MIM:618355
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIE2; KCR1; ALG10A
Summary
This gene encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat protein homolog was shown to specifically modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel. [provided by RefSeq, Jan 2010]
Expression
Ubiquitous expression in testis (RPKM 2.3), thyroid (RPKM 2.0) and 25 other tissues See more
Orthologs

Genomic context

See ALG10 in Genome Data Viewer
Location:
12p11.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (34022315..34035296)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (34175216..34181237)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369726 Neighboring gene RNA, U6 small nuclear 472, pseudogene Neighboring gene tubulin beta 8 class VIII pseudogene 4 Neighboring gene RNA, 5S ribosomal pseudogene 357

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14751

Gene Ontology Provided by GOA

Process Evidence Code Pubs
dolichol-linked oligosaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
Names
alpha-1,2-glucosyltransferase ALG10-A
alpha-2-glucosyltransferase ALG10-A
alpha2-glucosyltransferase
asparagine-linked glycosylation 10 homolog (yeast, alpha-1,2-glucosyltransferase)
asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog
asparagine-linked glycosylation protein 10 homolog A
derepression of ITR1 expression 2 homolog
dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2- glucosyltransferase
potassium channel regulator 1
NP_116223.3
XP_024304998.1
XP_024304999.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016389.1 RefSeqGene

    Range
    5001..11022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032834.4NP_116223.3  dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

    See identical proteins and their annotated locations for NP_116223.3

    Status: REVIEWED

    Source sequence(s)
    AC046130, AJ312278, AK027657, BC090948, W05355
    Consensus CDS
    CCDS41769.1
    UniProtKB/Swiss-Prot
    Q5BKT4
    Related
    ENSP00000266483.2, ENST00000266483.7
    Conserved Domains (1) summary
    pfam04922
    Location:33427
    DIE2_ALG10; DIE2/ALG10 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    34022315..34035296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449230.1XP_024304998.1  dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase isoform X1

    Conserved Domains (1) summary
    pfam04922
    Location:1367
    DIE2_ALG10; DIE2/ALG10 family
  2. XM_024449231.1XP_024304999.1  dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase isoform X1

    Conserved Domains (1) summary
    pfam04922
    Location:1367
    DIE2_ALG10; DIE2/ALG10 family
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