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Alg10b ALG10 alpha-1,2-glucosyltransferase [ Mus musculus (house mouse) ]

Gene ID: 380959, updated on 8-Jun-2024


Official Symbol
Alg10bprovided by MGI
Official Full Name
ALG10 alpha-1,2-glucosyltransferaseprovided by MGI
Primary source
See related
Ensembl:ENSMUSG00000075470 AllianceGenome:MGI:2146159
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
nse5; Deaf1; Gm917
Predicted to enable dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity. Acts upstream of or within auditory receptor cell development and sensory perception of sound. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Used to study nonsyndromic deafness. Human ortholog(s) of this gene implicated in long QT syndrome 2. Orthologous to several human genes including ALG10B (ALG10 alpha-1,2-glucosyltransferase B). [provided by Alliance of Genome Resources, Apr 2022]
Ubiquitous expression in whole brain E14.5 (RPKM 13.4), CNS E11.5 (RPKM 12.0) and 28 other tissues See more
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Genomic context

See Alg10b in Genome Data Viewer
15 E3; 15 45.07 cM
Exon count:
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (90108506..90117674)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (90224311..90230554)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin X Neighboring gene STARR-seq mESC enhancer starr_39472 Neighboring gene STARR-seq mESC enhancer starr_39473 Neighboring gene STARR-seq mESC enhancer starr_39474 Neighboring gene predicted gene, 36330 Neighboring gene predicted gene, 24415 Neighboring gene STARR-seq mESC enhancer starr_39475 Neighboring gene STARR-seq mESC enhancer starr_39477 Neighboring gene STARR-seq mESC enhancer starr_39478 Neighboring gene microRNA 7648 Neighboring gene predicted gene, 36480 Neighboring gene STARR-seq mESC enhancer starr_39480 Neighboring gene WEE1 homolog 2 pseudogene

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information


Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
enables transferase activity ISO
Inferred from Sequence Orthology
more info
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
located_in membrane IEA
Inferred from Electronic Annotation
more info
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
alpha-1,2-glucosyltransferase ALG10-A
alpha-2-glucosyltransferase ALG10-B
asparagine-linked glycosylation 10 homolog B (yeast, alpha-1,2-glucosyltransferase)
asparagine-linked glycosylation 10B (alpha-1,2-glucosyltransferase)
asparagine-linked glycosylation protein 10 homolog B
potassium channel regulator 1
putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
putative alpha-1,2-glucosyltransferase ALG10-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033441.4NP_001028613.1  dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

    See identical proteins and their annotated locations for NP_001028613.1

    Status: VALIDATED

    Source sequence(s)
    Consensus CDS
    Q3TLS4, Q3UGP8
    ENSMUSP00000097882.2, ENSMUST00000100309.3
    Conserved Domains (1) summary
    DIE2_ALG10; DIE2/ALG10 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000081.7 Reference GRCm39 C57BL/6J

    GenBank, FASTA, Sequence Viewer (Graphics)