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NFATC2IP nuclear factor of activated T cells 2 interacting protein [ Homo sapiens (human) ]

Gene ID: 84901, updated on 21-Dec-2019

Summary

Official Symbol
NFATC2IPprovided by HGNC
Official Full Name
nuclear factor of activated T cells 2 interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:25906
See related
Ensembl:ENSG00000176953 MIM:614525
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESC2; NIP45; RAD60
Expression
Ubiquitous expression in lymph node (RPKM 11.4), spleen (RPKM 10.6) and 25 other tissues See more
Orthologs

Genomic context

See NFATC2IP in Genome Data Viewer
Location:
16p11.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (28950992..28966465)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28962318..28977786)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 Neighboring gene rabaptin, RAB GTPase binding effector protein 2 Neighboring gene CD19 molecule Neighboring gene microRNA 4517 Neighboring gene sphingolipid transporter 1 (putative) Neighboring gene linker for activation of T cells

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14639, MGC126790, MGC138387

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cytokine production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NFATC2-interacting protein
Names
45 kDa NF-AT-interacting protein
45 kDa NFAT-interacting protein
nuclear factor of activated T-cells, cytoplasmic 2-interacting protein
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032815.3NP_116204.3  NFATC2-interacting protein

    See identical proteins and their annotated locations for NP_116204.3

    Status: VALIDATED

    Source sequence(s)
    AF458593, AK027545, AK074761, AL043335, BC010161
    Consensus CDS
    CCDS10645.1
    UniProtKB/Swiss-Prot
    Q8NCF5
    Related
    ENSP00000324792.4, ENST00000320805.8
    Conserved Domains (2) summary
    smart00213
    Location:265334
    UBQ; Ubiquitin homologues
    pfam11976
    Location:348417
    Rad60-SLD; Ubiquitin-2 like Rad60 SUMO-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    28950992..28966465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_950864.3 RNA Sequence

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