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CBR4 carbonyl reductase 4 [ Homo sapiens (human) ]

Gene ID: 84869, updated on 1-Jun-2020

Summary

Official Symbol
CBR4provided by HGNC
Official Full Name
carbonyl reductase 4provided by HGNC
Primary source
HGNC:HGNC:25891
See related
Ensembl:ENSG00000145439
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDR45C1
Expression
Ubiquitous expression in lung (RPKM 23.4), fat (RPKM 17.8) and 25 other tissues See more
Orthologs

Genomic context

See CBR4 in Genome Data Viewer
Location:
4q32.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (168894484..169010284, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (169815774..169931468, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene palladin, cytoskeletal associated protein Neighboring gene uncharacterized LOC102723331 Neighboring gene RNA, U6 small nuclear 853, pseudogene Neighboring gene uncharacterized LOC107986200 Neighboring gene RNY4 pseudogene 17 Neighboring gene uncharacterized LOC105377527 Neighboring gene SH3 domain containing ring finger 1 Neighboring gene ribosomal protein L6 pseudogene 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14431

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
NAD(P)H dehydrogenase (quinone) activity IDA
Inferred from Direct Assay
more info
PubMed 
NADPH binding IDA
Inferred from Direct Assay
more info
PubMed 
NADPH dehydrogenase (quinone) activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
quinone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
quinone binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
daunorubicin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
doxorubicin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
fatty-acyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
protein heterotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
oxidoreductase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
carbonyl reductase family member 4
Names
3-ketoacyl-[acyl-carrier-protein] reductase beta subunit
3-oxoacyl-[acyl-carrier-protein] reductase
KAR beta subunit
carbonic reductase 4
quinone reductase CBR4
short chain dehydrogenase/reductase family 45C member 1
NP_116172.2
XP_005263372.1
XP_005263373.1
XP_006714454.1
XP_006714455.1
XP_011530687.1
XP_011530688.1
XP_016864271.1
XP_016864272.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032783.5NP_116172.2  carbonyl reductase family member 4

    See identical proteins and their annotated locations for NP_116172.2

    Status: VALIDATED

    Source sequence(s)
    AC021151, AL833393, BC033650, DA217727
    Consensus CDS
    CCDS3812.1
    UniProtKB/Swiss-Prot
    Q8N4T8
    Related
    ENSP00000303525.3, ENST00000306193.8
    Conserved Domains (1) summary
    cl25409
    Location:3233
    SDR; Short-chain dehydrogenases/reductases (SDR)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    168894484..169010284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008782.1XP_016864271.1  carbonyl reductase family member 4 isoform X2

    Related
    ENSP00000423128.1, ENST00000504561.1
  2. XM_005263315.3XP_005263372.1  carbonyl reductase family member 4 isoform X3

    Related
    ENSP00000427615.1, ENST00000504480.5
    Conserved Domains (2) summary
    cd05233
    Location:5181
    SDR_c; classical (c) SDRs
    pfam00106
    Location:3192
    adh_short; short chain dehydrogenase
  3. XM_017008783.2XP_016864272.1  carbonyl reductase family member 4 isoform X5

  4. XM_011532385.1XP_011530687.1  carbonyl reductase family member 4 isoform X7

    Conserved Domains (2) summary
    TIGR01830
    Location:7188
    3oxo_ACP_reduc; 3-oxoacyl-(acyl-carrier-protein) reductase
    cl21454
    Location:3188
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. XM_006714391.1XP_006714454.1  carbonyl reductase family member 4 isoform X1

    Conserved Domains (2) summary
    TIGR01830
    Location:7243
    3oxo_ACP_reduc; 3-oxoacyl-(acyl-carrier-protein) reductase
    cl21454
    Location:3243
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  6. XM_006714392.3XP_006714455.1  carbonyl reductase family member 4 isoform X4

    Conserved Domains (2) summary
    pfam00106
    Location:3188
    adh_short; short chain dehydrogenase
    cl21454
    Location:3188
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  7. XM_005263316.4XP_005263373.1  carbonyl reductase family member 4 isoform X6

    Conserved Domains (2) summary
    pfam00106
    Location:3178
    adh_short; short chain dehydrogenase
    cl21454
    Location:3178
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  8. XM_011532386.2XP_011530688.1  carbonyl reductase family member 4 isoform X8

    Conserved Domains (1) summary
    cl21454
    Location:5144
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. XR_001741341.1 RNA Sequence

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