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Cbr4 carbonyl reductase 4 [ Mus musculus (house mouse) ]

Gene ID: 234309, updated on 5-Mar-2024

Summary

Official Symbol
Cbr4provided by MGI
Official Full Name
carbonyl reductase 4provided by MGI
Primary source
MGI:MGI:2384567
See related
Ensembl:ENSMUSG00000031641 AllianceGenome:MGI:2384567
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A730083J17Rik
Summary
Predicted to enable several functions, including 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NADPH binding activity; and NADPH dehydrogenase (quinone) activity. Predicted to be involved in fatty acid biosynthetic process; glycoside metabolic process; and protein tetramerization. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrion. Orthologous to human CBR4 (carbonyl reductase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 7.8), heart adult (RPKM 7.7) and 26 other tissues See more
Orthologs
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Genomic context

See Cbr4 in Genome Data Viewer
Location:
8 B3.1; 8 31.18 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (61940768..61956534)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (61487734..61503500)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene SH3 domain containing ring finger 1 Neighboring gene RIKEN cDNA 5730405A17 gene Neighboring gene STARR-positive B cell enhancer ABC_E10501 Neighboring gene STARR-seq mESC enhancer starr_21586 Neighboring gene predicted gene, 53435 Neighboring gene STARR-seq mESC enhancer starr_21587 Neighboring gene STARR-seq mESC enhancer starr_21588 Neighboring gene STARR-seq mESC enhancer starr_21589 Neighboring gene palladin, cytoskeletal associated protein Neighboring gene STARR-seq mESC enhancer starr_21591 Neighboring gene STARR-seq mESC enhancer starr_21593 Neighboring gene predicted gene, 35254 Neighboring gene STARR-seq mESC enhancer starr_21597 Neighboring gene predicted gene, 51576

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC6971

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD(P)H dehydrogenase (quinone) activity ISO
Inferred from Sequence Orthology
more info
 
enables NADPH binding ISO
Inferred from Sequence Orthology
more info
 
enables NADPH dehydrogenase (quinone) activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
 
enables quinone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables quinone binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in daunorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in doxorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein heterotetramerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
part_of oxidoreductase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
3-oxoacyl-[acyl-carrier-protein] reductase
Names
3-ketoacyl-[acyl-carrier-protein] reductase beta subunit
KAR beta subunit
carbonyl reductase family member 4
quinone reductase CBR4
NP_663570.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145595.2NP_663570.2  3-oxoacyl-[acyl-carrier-protein] reductase

    See identical proteins and their annotated locations for NP_663570.2

    Status: VALIDATED

    Source sequence(s)
    AK043313, AK150763
    Consensus CDS
    CCDS40349.1
    UniProtKB/Swiss-Prot
    Q3UBY4, Q8BXV1, Q91VT4
    Related
    ENSMUSP00000034058.7, ENSMUST00000034058.14
    Conserved Domains (2) summary
    PRK05653
    Location:1234
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated
    cl21454
    Location:3232
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    61940768..61956534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)