Format

Send to:

Choose Destination

PLCD4 phospholipase C delta 4 [ Homo sapiens (human) ]

Gene ID: 84812, updated on 3-Mar-2019

Summary

Official Symbol
PLCD4provided by HGNC
Official Full Name
phospholipase C delta 4provided by HGNC
Primary source
HGNC:HGNC:9062
See related
Ensembl:ENSG00000115556 MIM:605939
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011]
Expression
Broad expression in esophagus (RPKM 2.6), testis (RPKM 2.2) and 23 other tissues See more
Orthologs

Genomic context

See PLCD4 in Genome Data Viewer
Location:
2q35
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (218606871..218637186)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219472488..219501909)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 37 Neighboring gene RNA, 7SK small nuclear pseudogene 38 Neighboring gene CCR4-NOT transcription complex subunit 9 Neighboring gene RNA, U6 small nuclear 136, pseudogene Neighboring gene transfer RNA-Gln (CTG) 16-1 Neighboring gene zinc finger protein 142 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed
Tat tat HIV-1 Tat induces release of calcium and TNF-alpha production, an effect mediated at least in part by activation of phospholipase C PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12837

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acrosome reaction IEA
Inferred from Electronic Annotation
more info
 
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
inositol trisphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
Names
PLC delta4
phosphoinositide phospholipase C-delta-4
NP_116115.1
XP_005246970.1
XP_011510314.1
XP_016860603.1
XP_016860604.1
XP_016860605.1
XP_016860606.1
XP_016860607.1
XP_016860608.1
XP_016860609.1
XP_024308950.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032726.4NP_116115.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

    See identical proteins and their annotated locations for NP_116115.1

    Status: REVIEWED

    Source sequence(s)
    AC012510, BC006355, BP361394
    Consensus CDS
    CCDS46516.1
    UniProtKB/Swiss-Prot
    Q9BRC7
    Related
    ENSP00000388631.2, ENST00000450993.6
    Conserved Domains (5) summary
    cd00275
    Location:626751
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd13363
    Location:18133
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    cd15898
    Location:138167
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl14615
    Location:289596
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl28895
    Location:138277
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    218606871..218637186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005118.2XP_016860607.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X5

  2. XM_011512012.1XP_011510314.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

    Conserved Domains (8) summary
    cd00275
    Location:658809
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    PLN02222
    Location:207765
    PLN02222; phosphoinositide phospholipase C 2
    cd13363
    Location:18133
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam00169
    Location:17123
    PH; PH domain
    pfam09279
    Location:207289
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:143199
    EF-hand_7; EF-hand domain pair
    pfam14788
    Location:153202
    EF-hand_10; EF hand
    cl14615
    Location:289628
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  3. XM_017005115.1XP_016860604.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

    Conserved Domains (8) summary
    cd00275
    Location:658809
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    PLN02222
    Location:207765
    PLN02222; phosphoinositide phospholipase C 2
    cd13363
    Location:18133
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam00169
    Location:17123
    PH; PH domain
    pfam09279
    Location:207289
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:143199
    EF-hand_7; EF-hand domain pair
    pfam14788
    Location:153202
    EF-hand_10; EF hand
    cl14615
    Location:289628
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  4. XM_017005116.1XP_016860605.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X2

    UniProtKB/TrEMBL
    C9JEA7
    Related
    ENSP00000396185.1, ENST00000432688.5
    Conserved Domains (4) summary
    cd00275
    Location:658783
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd13363
    Location:18133
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    cd16219
    Location:138277
    EFh_PI-PLCdelta4; EF-hand motif found in phosphoinositide phospholipase C delta 4 (PI-PLC-delta4)
    cl14615
    Location:289628
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  5. XM_024453182.1XP_024308950.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X2

    Conserved Domains (4) summary
    cd00275
    Location:658783
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd13363
    Location:18133
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    cd16219
    Location:138277
    EFh_PI-PLCdelta4; EF-hand motif found in phosphoinositide phospholipase C delta 4 (PI-PLC-delta4)
    cl14615
    Location:289628
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  6. XM_005246913.2XP_005246970.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X3

    Conserved Domains (8) summary
    cd00275
    Location:626777
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    PLN02222
    Location:207733
    PLN02222; phosphoinositide phospholipase C 2
    cd13363
    Location:18133
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam00169
    Location:17123
    PH; PH domain
    pfam09279
    Location:207289
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:143199
    EF-hand_7; EF-hand domain pair
    pfam14788
    Location:153202
    EF-hand_10; EF hand
    cl14615
    Location:289596
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  7. XM_017005117.1XP_016860606.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X4

  8. XM_017005114.1XP_016860603.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

    Conserved Domains (8) summary
    cd00275
    Location:658809
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    PLN02222
    Location:207765
    PLN02222; phosphoinositide phospholipase C 2
    cd13363
    Location:18133
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam00169
    Location:17123
    PH; PH domain
    pfam09279
    Location:207289
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:143199
    EF-hand_7; EF-hand domain pair
    pfam14788
    Location:153202
    EF-hand_10; EF hand
    cl14615
    Location:289628
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  9. XM_017005119.2XP_016860608.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X6

  10. XM_017005120.2XP_016860609.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X7

RNA

  1. XR_241325.1 RNA Sequence

Support Center