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IRS4 insulin receptor substrate 4 [ Homo sapiens (human) ]

Gene ID: 8471, updated on 5-Jul-2020

Summary

Official Symbol
IRS4provided by HGNC
Official Full Name
insulin receptor substrate 4provided by HGNC
Primary source
HGNC:HGNC:6128
See related
Ensembl:ENSG00000133124 MIM:300904
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHNG9; IRS-4; PY160
Summary
IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.. [provided by RefSeq, Jul 2008]
Expression
Biased expression in ovary (RPKM 3.0), thyroid (RPKM 1.0) and 3 other tissues See more
Orthologs

Genomic context

See IRS4 in Genome Data Viewer
Location:
Xq22.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (108719946..108736584, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (107963179..107979643, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene collagen type IV alpha 6 chain Neighboring gene collagen type IV alpha 5 chain Neighboring gene uncharacterized LOC101928358 Neighboring gene RNA, U6 small nuclear 309, pseudogene Neighboring gene Sharpr-MPRA regulatory region 8383 Neighboring gene guanylate cyclase 2F, retinal

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated insulin receptor substrate 4 (IRS4) is incorporated into HIV-1 Gag virus-like particles PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
insulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
insulin receptor substrate 4
Names
160 kDa phosphotyrosine protein
phosphoprotein of 160 kDa
pp160

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013239.1 RefSeqGene

    Range
    5001..8881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001379150.1NP_001366079.1  insulin receptor substrate 4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL035425
  2. NM_003604.2NP_003595.1  insulin receptor substrate 4

    See identical proteins and their annotated locations for NP_003595.1

    Status: REVIEWED

    Source sequence(s)
    AF007567
    Consensus CDS
    CCDS14544.1
    UniProtKB/Swiss-Prot
    O14654
    Related
    ENSP00000361202.2, ENST00000372129.3
    Conserved Domains (2) summary
    cd01204
    Location:231334
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:79202
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    108719946..108736584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531061.1XP_011529363.1  insulin receptor substrate 4 isoform X1

    Conserved Domains (2) summary
    cd01204
    Location:231334
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:79202
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
  2. XM_006724713.3XP_006724776.1  insulin receptor substrate 4 isoform X3

    Conserved Domains (2) summary
    cd01204
    Location:231334
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:79202
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
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