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ADGRE3 adhesion G protein-coupled receptor E3 [ Homo sapiens (human) ]

Gene ID: 84658, updated on 24-Nov-2020

Summary

Official Symbol
ADGRE3provided by HGNC
Official Full Name
adhesion G protein-coupled receptor E3provided by HGNC
Primary source
HGNC:HGNC:23647
See related
Ensembl:ENSG00000131355 MIM:606101
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EMR3
Summary
This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]
Expression
Biased expression in appendix (RPKM 3.7), spleen (RPKM 2.5) and 12 other tissues See more
Orthologs
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Genomic context

See ADGRE3 in Genome Data Viewer
Location:
19p13.12
Exon count:
17
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (14600175..14674860, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14730051..14785730, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 337, pseudogene Neighboring gene C-type lectin domain containing 17A Neighboring gene RNA, 7SL, cytoplasmic 842, pseudogene Neighboring gene small nucleolar RNA, H/ACA box 104 Neighboring gene integrin subunit beta 1 pseudogene 1 Neighboring gene uncharacterized LOC107985308 Neighboring gene zinc finger protein 333 Neighboring gene adhesion G protein-coupled receptor E2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of egf-like module containing, mucin-like, hormone receptor-like 3 (EMR3) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
adhesion G protein-coupled receptor E3
Names
EGF-like module receptor 3
EGF-like module-containing mucin-like hormone receptor-like 3
egf-like module containing, mucin-like, hormone receptor-like 3
egf-like module-containing mucin-like receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289158.2NP_001276087.1  adhesion G protein-coupled receptor E3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001276087.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AF239764, AK298653, AL832663, AY358817, BC128053
    Consensus CDS
    CCDS74297.1
    UniProtKB/Swiss-Prot
    Q9BY15
    UniProtKB/TrEMBL
    A1L1B9, B7Z5A1
    Related
    ENSP00000340758.4, ENST00000344373.8
    Conserved Domains (2) summary
    pfam01825
    Location:252292
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:301542
    7tm_4; Olfactory receptor
  2. NM_001289159.2NP_001276088.1  adhesion G protein-coupled receptor E3 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks three alternate in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter isoform (3), compared to isoform 1.
    Source sequence(s)
    AF239764, AK298653, BC128053
    Consensus CDS
    CCDS74296.1
    UniProtKB/Swiss-Prot
    Q9BY15
    UniProtKB/TrEMBL
    A1L1B9, B7Z5A1, E7EW83
    Related
    ENSP00000396208.2, ENST00000443157.6
    Conserved Domains (2) summary
    pfam01825
    Location:178218
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:227468
    7tm_4; Olfactory receptor
  3. NM_032571.5NP_115960.2  adhesion G protein-coupled receptor E3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_115960.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF239764, AK298653, AL832663, BC121130, BC128053
    Consensus CDS
    CCDS12315.1
    UniProtKB/Swiss-Prot
    Q9BY15
    UniProtKB/TrEMBL
    A1L1B9, B7Z5A1, Q0IJ53
    Related
    ENSP00000253673.4, ENST00000253673.6
    Conserved Domains (3) summary
    cd00054
    Location:67104
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01825
    Location:304344
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:353594
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    14600175..14674860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528374.2XP_011526676.1  adhesion G protein-coupled receptor E3 isoform X1

    Conserved Domains (3) summary
    cd00054
    Location:5087
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01825
    Location:287327
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:336577
    7tm_4; Olfactory receptor
  2. XM_017027383.1XP_016882872.1  adhesion G protein-coupled receptor E3 isoform X2

    UniProtKB/TrEMBL
    M0R1G2
    Related
    ENSP00000471853.1, ENST00000599900.5

RNA

  1. XR_001753772.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152939.1: Suppressed sequence

    Description
    NM_152939.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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