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FNDC1 fibronectin type III domain containing 1 [ Homo sapiens (human) ]

Gene ID: 84624, updated on 5-Sep-2021

Summary

Official Symbol
FNDC1provided by HGNC
Official Full Name
fibronectin type III domain containing 1provided by HGNC
Primary source
HGNC:HGNC:21184
See related
Ensembl:ENSG00000164694 MIM:609991
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AGS8; FNDC2; MEL4B3; bA243O10.1; dJ322A24.1
Expression
Biased expression in gall bladder (RPKM 10.5), thyroid (RPKM 9.5) and 12 other tissues See more
Orthologs
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Genomic context

See FNDC1 in Genome Data Viewer
Location:
6q25.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (159169400..159272108)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (159590432..159693140)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene TAGAP antisense RNA 1 Neighboring gene uncharacterized LOC112267968 Neighboring gene VISTA enhancer hs2576 Neighboring gene FNDC1 antisense RNA 1 Neighboring gene FNDC1 intronic transcript 1 Neighboring gene uncharacterized LOC105378084 Neighboring gene long intergenic non-protein coding RNA 2529

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1866

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
fibronectin type III domain-containing protein 1
Names
activation-associated cDNA protein
expressed in synovial lining protein
fibronectin type III domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032532.3NP_115921.2  fibronectin type III domain-containing protein 1 precursor

    See identical proteins and their annotated locations for NP_115921.2

    Status: VALIDATED

    Source sequence(s)
    AL356417, AL590551, DQ009660
    Consensus CDS
    CCDS47512.1
    UniProtKB/Swiss-Prot
    Q4ZHG4
    Related
    ENSP00000297267.9, ENST00000297267.14
    Conserved Domains (2) summary
    smart00060
    Location:40120
    FN3; Fibronectin type 3 domain
    cd00063
    Location:16581749
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    159169400..159272108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536190.2XP_011534492.1  fibronectin type III domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    smart00060
    Location:40120
    FN3; Fibronectin type 3 domain
    cd00063
    Location:16351726
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_011536191.2XP_011534493.1  fibronectin type III domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    smart00060
    Location:41124
    FN3; Fibronectin type 3 domain
    cd00063
    Location:15411632
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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