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CUL2 cullin 2 [ Homo sapiens (human) ]

Gene ID: 8453, updated on 7-Jun-2020

Summary

Official Symbol
CUL2provided by HGNC
Official Full Name
cullin 2provided by HGNC
Primary source
HGNC:HGNC:2552
See related
Ensembl:ENSG00000108094 MIM:603135
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 12.7), brain (RPKM 7.3) and 25 other tissues See more
Orthologs

Genomic context

See CUL2 in Genome Data Viewer
Location:
10p11.21
Exon count:
29
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (35008551..35126899, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (35297479..35379570, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 2 pseudogene 2 Neighboring gene long intergenic non-protein coding RNA 2635 Neighboring gene microRNA 3611 Neighboring gene RNA, U7 small nuclear 77 pseudogene Neighboring gene cAMP responsive element modulator Neighboring gene ATPase H+ transporting V1 subunit G1 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif is identified to have a physical interaction with Cullin 2 (CUL2) in human HEK293 and/or Jurkat cell lines PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131970

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intrinsic apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination TAS
Traceable Author Statement
more info
 
regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
VCB complex IEA
Inferred from Electronic Annotation
more info
 
cullin-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cullin-2
Names
CUL-2
testis secretory sperm-binding protein Li 238E

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198777.2NP_001185706.1  cullin-2 isoform c

    See identical proteins and their annotated locations for NP_001185706.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AI089201, AK095217, AL392046, BC009591
    Consensus CDS
    CCDS7179.1
    UniProtKB/Swiss-Prot
    Q13617
    UniProtKB/TrEMBL
    A0A140VKB1
    Related
    ENSP00000363883.3, ENST00000374751.7
    Conserved Domains (2) summary
    pfam00888
    Location:14644
    Cullin; Cullin family
    pfam10557
    Location:677735
    Cullin_Nedd8; Cullin protein neddylation domain
  2. NM_001198778.2NP_001185707.1  cullin-2 isoform a

    See identical proteins and their annotated locations for NP_001185707.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AI089201, AL392046, BC009591, DC401811
    Consensus CDS
    CCDS55709.1
    UniProtKB/Swiss-Prot
    Q13617
    Related
    ENSP00000414095.2, ENST00000421317.4
    Conserved Domains (2) summary
    pfam00888
    Location:34662
    Cullin; Cullin family
    pfam10557
    Location:696754
    Cullin_Nedd8; Cullin protein neddylation domain
  3. NM_001198779.1NP_001185708.1  cullin-2 isoform b

    See identical proteins and their annotated locations for NP_001185708.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AI089201, AK310225, AL392046, BC009591, DC401811
    Consensus CDS
    CCDS73086.1
    UniProtKB/Swiss-Prot
    Q13617
    UniProtKB/TrEMBL
    A0A0A0MTN0
    Related
    ENSP00000444856.2, ENST00000537177.5
    Conserved Domains (2) summary
    pfam00888
    Location:28656
    Cullin; Cullin family
    pfam10557
    Location:690748
    Cullin_Nedd8; Cullin protein neddylation domain
  4. NM_001324375.2NP_001311304.1  cullin-2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AK294080, AL392046
    UniProtKB/TrEMBL
    B7Z1Y1
  5. NM_001324376.2NP_001311305.1  cullin-2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AK310225, AL392046
    Conserved Domains (2) summary
    pfam00888
    Location:5512
    Cullin; Cullin family
    pfam10557
    Location:546604
    Cullin_Nedd8; Cullin protein neddylation domain
  6. NM_003591.4NP_003582.2  cullin-2 isoform c

    See identical proteins and their annotated locations for NP_003582.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AI089201, AL392046, BC009591, DC401936
    Consensus CDS
    CCDS7179.1
    UniProtKB/Swiss-Prot
    Q13617
    UniProtKB/TrEMBL
    A0A140VKB1
    Related
    ENSP00000363881.3, ENST00000374749.7
    Conserved Domains (2) summary
    pfam00888
    Location:14644
    Cullin; Cullin family
    pfam10557
    Location:677735
    Cullin_Nedd8; Cullin protein neddylation domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    35008551..35126899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519745.1XP_011518047.1  cullin-2 isoform X1

    See identical proteins and their annotated locations for XP_011518047.1

    Conserved Domains (3) summary
    smart00182
    Location:487631
    CULLIN; Cullin
    smart00884
    Location:735802
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:93706
    Cullin; Cullin family
  2. XM_011519743.1XP_011518045.1  cullin-2 isoform X1

    See identical proteins and their annotated locations for XP_011518045.1

    Conserved Domains (3) summary
    smart00182
    Location:487631
    CULLIN; Cullin
    smart00884
    Location:735802
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:93706
    Cullin; Cullin family
  3. XM_011519744.1XP_011518046.1  cullin-2 isoform X1

    See identical proteins and their annotated locations for XP_011518046.1

    Conserved Domains (3) summary
    smart00182
    Location:487631
    CULLIN; Cullin
    smart00884
    Location:735802
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:93706
    Cullin; Cullin family
  4. XM_011519747.1XP_011518049.1  cullin-2 isoform X2

    See identical proteins and their annotated locations for XP_011518049.1

    UniProtKB/Swiss-Prot
    Q13617
    UniProtKB/TrEMBL
    A0A140VKB1
    Related
    ENSP00000363880.1, ENST00000374748.5
    Conserved Domains (2) summary
    pfam00888
    Location:14644
    Cullin; Cullin family
    pfam10557
    Location:677735
    Cullin_Nedd8; Cullin protein neddylation domain
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