CUL2 cullin 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CUL2provided by HGNC
Official Full Name: cullin 2provided by HGNC
Primary source: HGNC:HGNC:2552
See related: Ensembl:ENSG00000108094 MIM:603135; AllianceGenome:HGNC:2552
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Enables ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in nucleoplasm. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2025]
Expression: Ubiquitous expression in testis (RPKM 12.7), brain (RPKM 7.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10p11.21

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (35008551..35127006, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (35037104..35155467, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (35297479..35379542, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRAF2 associates with cullin neddylation complex assembly.
Title: TRAF2 associates with cullin neddylation complex assembly.
Comprehensive prognostic and immunological analysis of Cullin2 in pan-cancer and its identification in hepatocellular carcinoma.
Title: Comprehensive prognostic and immunological analysis of Cullin2 in pan-cancer and its identification in hepatocellular carcinoma.
MicroRNA-154-5p suppresses cervical carcinoma growth and metastasis by silencing Cullin2 in vitro and in vivo.
Title: MicroRNA-154-5p suppresses cervical carcinoma growth and metastasis by silencing Cullin2 in vitro and in vivo.
MicroRNA-574-3p Regulates HIF-alpha Isoforms Promoting Gastric Cancer Epithelial-Mesenchymal Transition via Targeting CUL2.
Title: MicroRNA-574-3p Regulates HIF-α Isoforms Promoting Gastric Cancer Epithelial-Mesenchymal Transition via Targeting CUL2.
A close shave: How SARS-CoV-2 induces the loss of cilia.
Title: A close shave: How SARS-CoV-2 induces the loss of cilia.
CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2.
Title: CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2.
Immunoexpression of HSPA9 and CUL2 in prostatic tissue and adenocarcinoma.
Title: Immunoexpression of HSPA9 and CUL2 in prostatic tissue and adenocarcinoma.
Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes.
Title: Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes.
Integrating cullin2-RING E3 ligase as a potential biomarker for glioblastoma multiforme prognosis and radiosensitivity profiling.
Title: Integrating cullin2-RING E3 ligase as a potential biomarker for glioblastoma multiforme prognosis and radiosensitivity profiling.
ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.
Title: ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vif	vif	HIV-1 Vif is identified to have a physical interaction with Cullin 2 (CUL2) in human HEK293 and/or Jurkat cell lines	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

CUL2_3202 (e-PCR)
- UniSTS:462138

D10S2194 (e-PCR)
- UniSTS:23746

RH11247 (e-PCR)
- UniSTS:92615

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin ligase complex scaffold activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	TAS Traceable Author Statement more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul2-RING ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Cul2-RING ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cullin-RING ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cullin-2

Names: CUL-2; testis secretory sperm-binding protein Li 238E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198777.2 → NP_001185706.1 cullin-2 isoform c

See identical proteins and their annotated locations for NP_001185706.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).

Source sequence(s)

AI089201, AK095217, AL392046, BC009591

Consensus CDS

CCDS7179.1

UniProtKB/Swiss-Prot

B3KT95, B7Z6K8, D3DRY6, G3V1S2, O00200, Q13617, Q5T2B6, Q9UNF9

UniProtKB/TrEMBL

A0A140VKB1, A0A8I5KUA9

Related

ENSP00000363883.3, ENST00000374751.7

Conserved Domains (2) summary

pfam00888
Location:14 → 644

Cullin; Cullin family

pfam10557
Location:675 → 735

Cullin_Nedd8; Cullin protein neddylation domain
NM_001198778.2 → NP_001185707.1 cullin-2 isoform a

See identical proteins and their annotated locations for NP_001185707.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AI089201, AL392046, BC009591, DC401811

Consensus CDS

CCDS55709.1

UniProtKB/TrEMBL

A0A8I5QJI3

Related

ENSP00000414095.2, ENST00000421317.5

Conserved Domains (2) summary

pfam00888
Location:34 → 662

Cullin; Cullin family

pfam10557
Location:696 → 754

Cullin_Nedd8; Cullin protein neddylation domain
NM_001198779.1 → NP_001185708.1 cullin-2 isoform b

See identical proteins and their annotated locations for NP_001185708.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AI089201, AK310225, AL392046, BC009591, DC401811

Consensus CDS

CCDS73086.1

UniProtKB/TrEMBL

A0A0A0MTN0, A0A8I5QJI3

Related

ENSP00000444856.2, ENST00000537177.6

Conserved Domains (2) summary

pfam00888
Location:28 → 656

Cullin; Cullin family

pfam10557
Location:690 → 748

Cullin_Nedd8; Cullin protein neddylation domain
NM_001324375.2 → NP_001311304.1 cullin-2 isoform d

Status: VALIDATED

Source sequence(s)

AK294080, AL392046

Consensus CDS

CCDS91236.1

UniProtKB/TrEMBL

A0A8I5KUA9, A0A8I5KVR3

Related

ENSP00000508924.1, ENST00000690123.1
NM_001324376.2 → NP_001311305.1 cullin-2 isoform e

Status: VALIDATED

Source sequence(s)

AK310225, AL392046

UniProtKB/TrEMBL

A0A8I5KUA9

Conserved Domains (2) summary

pfam00888
Location:5 → 512

Cullin; Cullin family

pfam10557
Location:546 → 604

Cullin_Nedd8; Cullin protein neddylation domain
NM_003591.4 → NP_003582.2 cullin-2 isoform c

See identical proteins and their annotated locations for NP_003582.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).

Source sequence(s)

AI089201, AL392046, BC009591, DC401936

Consensus CDS

CCDS7179.1

UniProtKB/Swiss-Prot

B3KT95, B7Z6K8, D3DRY6, G3V1S2, O00200, Q13617, Q5T2B6, Q9UNF9

UniProtKB/TrEMBL

A0A140VKB1, A0A8I5KUA9

Related

ENSP00000363881.3, ENST00000374749.8

Conserved Domains (2) summary

pfam00888
Location:14 → 644

Cullin; Cullin family

pfam10557
Location:675 → 735

Cullin_Nedd8; Cullin protein neddylation domain