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ZMAT1 zinc finger matrin-type 1 [ Homo sapiens (human) ]

Gene ID: 84460, updated on 7-Jun-2020

Summary

Official Symbol
ZMAT1provided by HGNC
Official Full Name
zinc finger matrin-type 1provided by HGNC
Primary source
HGNC:HGNC:29377
See related
Ensembl:ENSG00000166432 MIM:301007
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein containing Cys2-His2 (C2H2)-type zinc fingers, which are similar to those found in the nuclear matrix protein matrin 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in thyroid (RPKM 9.8), ovary (RPKM 6.5) and 25 other tissues See more
Orthologs

Genomic context

See ZMAT1 in Genome Data Viewer
Location:
Xq22.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (101882288..101932135, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (101137260..101187108, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene glycerol kinase 4 pseudogene Neighboring gene nuclear RNA export factor 5 Neighboring gene RNA, U6 small nuclear 345, pseudogene Neighboring gene H2B histone pseudogene 8 Neighboring gene MT-ND6 pseudogene 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1789, MGC176597, MGC176728

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger matrin-type protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016330.2 RefSeqGene

    Range
    4738..54475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001011657.4NP_001011657.2  zinc finger matrin-type protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA459272, AK296520, BC045706, BC152470, DA824319, Z68868, Z69304
    Consensus CDS
    CCDS35348.1
    UniProtKB/TrEMBL
    A7MD47
    Related
    ENSP00000361868.3, ENST00000372782.4
    Conserved Domains (2) summary
    smart00451
    Location:118152
    ZnF_U1; U1-like zinc finger
    pfam08576
    Location:532584
    DUF1764; Eukaryotic protein of unknown function (DUF1764)
  2. NM_001282400.2NP_001269329.1  zinc finger matrin-type protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001269329.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon structure and thus differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus, compared to isoform 1. Both variants 2 and 4 encode the same isoform (4).
    Source sequence(s)
    AA459272, AK094141, AL831883, Z68868
    UniProtKB/Swiss-Prot
    Q5H9K5
    UniProtKB/TrEMBL
    A7MD47
    Conserved Domains (1) summary
    pfam08576
    Location:361413
    DUF1764; Eukaryotic protein of unknown function (DUF1764)
  3. NM_001282401.2NP_001269330.1  zinc finger matrin-type protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001269330.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' exon structure and thus differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus, compared to isoform 1. Both variants 2 and 4 encode the same isoform (4).
    Source sequence(s)
    AA459272, AK296520, AL831883
    UniProtKB/Swiss-Prot
    Q5H9K5
    UniProtKB/TrEMBL
    A7MD47
    Related
    ENST00000458570.5
    Conserved Domains (1) summary
    pfam08576
    Location:361413
    DUF1764; Eukaryotic protein of unknown function (DUF1764)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    101882288..101932135 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262214.4XP_005262271.2  zinc finger matrin-type protein 1 isoform X3

    Related
    ENSP00000498446.1, ENST00000651725.1
    Conserved Domains (2) summary
    smart00451
    Location:175209
    ZnF_U1; U1-like zinc finger
    pfam08576
    Location:589641
    DUF1764; Eukaryotic protein of unknown function (DUF1764)
  2. XM_005262213.4XP_005262270.2  zinc finger matrin-type protein 1 isoform X2

    Conserved Domains (2) summary
    smart00451
    Location:175209
    ZnF_U1; U1-like zinc finger
    pfam08576
    Location:611663
    DUF1764; Eukaryotic protein of unknown function (DUF1764)
  3. XM_005262212.4XP_005262269.2  zinc finger matrin-type protein 1 isoform X1

    Conserved Domains (2) summary
    smart00451
    Location:175209
    ZnF_U1; U1-like zinc finger
    pfam08576
    Location:612664
    DUF1764; Eukaryotic protein of unknown function (DUF1764)
  4. XM_017029903.1XP_016885392.1  zinc finger matrin-type protein 1 isoform X5

  5. XM_005262216.4XP_005262273.2  zinc finger matrin-type protein 1 isoform X4

    Conserved Domains (2) summary
    smart00451
    Location:5589
    ZnF_U1; U1-like zinc finger
    pfam08576
    Location:492544
    DUF1764; Eukaryotic protein of unknown function (DUF1764)
  6. XM_017029904.1XP_016885393.1  zinc finger matrin-type protein 1 isoform X6

    UniProtKB/Swiss-Prot
    Q5H9K5
    UniProtKB/TrEMBL
    A7MD47
    Conserved Domains (1) summary
    pfam08576
    Location:361413
    DUF1764; Eukaryotic protein of unknown function (DUF1764)
  7. XM_006724711.3XP_006724774.1  zinc finger matrin-type protein 1 isoform X6

    See identical proteins and their annotated locations for XP_006724774.1

    UniProtKB/Swiss-Prot
    Q5H9K5
    UniProtKB/TrEMBL
    A7MD47
    Conserved Domains (1) summary
    pfam08576
    Location:361413
    DUF1764; Eukaryotic protein of unknown function (DUF1764)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_036431.1: Suppressed sequence

    Description
    NR_036431.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which appears to retain intronic sequence at its 5' end.
  2. NR_046008.1: Suppressed sequence

    Description
    NR_046008.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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