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LZTS2 leucine zipper tumor suppressor 2 [ Homo sapiens (human) ]

Gene ID: 84445, updated on 21-Dec-2019

Summary

Official Symbol
LZTS2provided by HGNC
Official Full Name
leucine zipper tumor suppressor 2provided by HGNC
Primary source
HGNC:HGNC:29381
See related
Ensembl:ENSG00000107816 MIM:610454
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAPSER1
Summary
The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in endometrium (RPKM 12.4), fat (RPKM 11.4) and 25 other tissues See more
Orthologs

Genomic context

See LZTS2 in Genome Data Viewer
Location:
10q24.31
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (100997065..101007836)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (102756864..102767593)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene semaphorin 4G Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene twinkle mtDNA helicase Neighboring gene PDZ domain containing 7 Neighboring gene sideroflexin 3 Neighboring gene uncharacterized LOC107984262 Neighboring gene Sharpr-MPRA regulatory region 11881

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1813

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
microtubule severing IEA
Inferred from Electronic Annotation
more info
 
mitotic cytokinesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
nuclear export IEA
Inferred from Electronic Annotation
more info
 
primary ureteric bud growth IEA
Inferred from Electronic Annotation
more info
 
spindle midzone assembly IEA
Inferred from Electronic Annotation
more info
 
ureter morphogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
midbody IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
leucine zipper putative tumor suppressor 2
Names
leucine zipper, putative tumor suppressor 2
protein LAPSER1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318099.2NP_001305028.1  leucine zipper putative tumor suppressor 2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and it thus differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 all encode the same isoform (a).
    Source sequence(s)
    AK298208, AL133215, BC006212, BC058938, HY037189
    Consensus CDS
    CCDS7507.1
    UniProtKB/Swiss-Prot
    Q9BRK4
    UniProtKB/TrEMBL
    B4DP66
    Conserved Domains (2) summary
    pfam06818
    Location:439635
    Fez1; Fez1
    cl25732
    Location:329537
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001318100.2NP_001305029.1  leucine zipper putative tumor suppressor 2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and it thus differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 all encode the same isoform (a).
    Source sequence(s)
    AL133215, BC006212, BC058938, CN365632
    Consensus CDS
    CCDS7507.1
    UniProtKB/Swiss-Prot
    Q9BRK4
    Related
    ENSP00000359240.1, ENST00000370220.1
    Conserved Domains (2) summary
    pfam06818
    Location:439635
    Fez1; Fez1
    cl25732
    Location:329537
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_001318101.1NP_001305030.1  leucine zipper putative tumor suppressor 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. This variant has an incomplete 5' UTR because there are no 5'-complete transcripts representing it, and there is splicing ambiguity at the 5' end of the gene.
    Source sequence(s)
    BC006212, BC058938, BU615934, CX755354
    UniProtKB/Swiss-Prot
    Q9BRK4
    Conserved Domains (1) summary
    pfam06818
    Location:219415
    Fez1; Fez1
  4. NM_032429.4NP_115805.1  leucine zipper putative tumor suppressor 2 isoform a

    See identical proteins and their annotated locations for NP_115805.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2 and 3 all encode isoform a.
    Source sequence(s)
    AL133215, BC006212, HY039896
    Consensus CDS
    CCDS7507.1
    UniProtKB/Swiss-Prot
    Q9BRK4
    Related
    ENSP00000359243.3, ENST00000370223.7
    Conserved Domains (2) summary
    pfam06818
    Location:439635
    Fez1; Fez1
    cl25732
    Location:329537
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    100997065..101007836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016781.1XP_016872270.1  leucine zipper putative tumor suppressor 2 isoform X2

    Conserved Domains (1) summary
    pfam06818
    Location:219415
    Fez1; Fez1
  2. XM_005270222.4XP_005270279.1  leucine zipper putative tumor suppressor 2 isoform X1

    See identical proteins and their annotated locations for XP_005270279.1

    UniProtKB/Swiss-Prot
    Q9BRK4
    Conserved Domains (2) summary
    pfam06818
    Location:439635
    Fez1; Fez1
    cl25732
    Location:329537
    SMC_N; RecF/RecN/SMC N terminal domain
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