Lzts2 leucine zipper, putative tumor suppressor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lzts2provided by MGI
Official Full Name: leucine zipper, putative tumor suppressor 2provided by MGI
Primary source: MGI:MGI:2385095
See related: Ensembl:ENSMUSG00000035342 AllianceGenome:MGI:2385095
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LAPSER1; mKIAA1813
Summary: Acts upstream of or within several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of protein localization to nucleus; and tube morphogenesis. Located in cytoplasm. Is expressed in several structures, including 1st branchial arch mandibular component; adrenal gland; forelimb bud; future brain; and genitourinary system. Used to study urinary system disease. Orthologous to human LZTS2 (leucine zipper tumor suppressor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in adrenal adult (RPKM 94.4), ovary adult (RPKM 63.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 38.2 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (45003615..45015554)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (45015176..45027115)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data demonstrate the significance of simultaneous Pten and Lzts2 deletion in oncogenic transformation in prostate cells and implicates a new mechanism for the dysregulation of Wnt/beta-catenin signaling in prostate tumorigenesis.
Title: LZTS2 and PTEN collaboratively regulate ß-catenin in prostatic tumorigenesis.
deletion of Lzts2 increases susceptibility to spontaneous and carcinogen-induced tumor development.
Title: Deletion of leucine zipper tumor suppressor 2 (Lzts2) increases susceptibility to tumor development.
a critical role of LZTS2 in renal development and implicate LZTS2 as a critical regulator of beta-catenin-mediated nephrogenesis.
Title: The leucine zipper putative tumor suppressor 2 protein LZTS2 regulates kidney development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C79039 (e-PCR)
- UniSTS:209471

D19Dcr34 (e-PCR), detects polymorphism
- UniSTS:532354

NoName (e-PCR)
- UniSTS:237956

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule severing	IEA Inferred from Electronic Annotation more info
involved_in mitotic cytokinesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear export	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within primary ureteric bud growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle midzone assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ureter morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	IEA Inferred from Electronic Annotation more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leucine zipper putative tumor suppressor 2

Names: protein LAPSER1; putative tumor suppressor LAPSER1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130525.1 → NP_001123997.1 leucine zipper putative tumor suppressor 2

See identical proteins and their annotated locations for NP_001123997.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.

Source sequence(s)

AA208269, AK129446, BX511791, CK021048

Consensus CDS

CCDS29855.1

UniProtKB/Swiss-Prot

E9QKK6, Q569X6, Q91YU6

Related

ENSMUSP00000137571.2, ENSMUST00000179108.9

Conserved Domains (2) summary

pfam06818
Location:441 → 637

Fez1

pfam13851
Location:404 → 476

GAS; Growth-arrest specific micro-tubule binding
NM_001130526.1 → NP_001123998.1 leucine zipper putative tumor suppressor 2

See identical proteins and their annotated locations for NP_001123998.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1.

Source sequence(s)

AA208269, AK129446, BY726859, CK021048

Consensus CDS

CCDS29855.1

UniProtKB/Swiss-Prot

E9QKK6, Q569X6, Q91YU6

Related

ENSMUSP00000136405.2, ENSMUST00000178087.3

Conserved Domains (2) summary

pfam06818
Location:441 → 637

Fez1

pfam13851
Location:404 → 476

GAS; Growth-arrest specific micro-tubule binding
NM_145503.2 → NP_663478.2 leucine zipper putative tumor suppressor 2

See identical proteins and their annotated locations for NP_663478.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript.

Source sequence(s)

AA208269, AK129446, BY202542, CK021048

Consensus CDS

CCDS29855.1

UniProtKB/Swiss-Prot

E9QKK6, Q569X6, Q91YU6

Related

ENSMUSP00000045478.7, ENSMUST00000039016.14

Conserved Domains (2) summary

pfam06818
Location:441 → 637

Fez1

pfam13851
Location:404 → 476

GAS; Growth-arrest specific micro-tubule binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

45003615..45015554

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527004.4 → XP_006527067.1 leucine zipper putative tumor suppressor 2 isoform X1

See identical proteins and their annotated locations for XP_006527067.1

UniProtKB/Swiss-Prot

E9QKK6, Q569X6, Q91YU6

Conserved Domains (2) summary

pfam06818
Location:441 → 637

Fez1

pfam13851
Location:404 → 476

GAS; Growth-arrest specific micro-tubule binding
XM_030250898.2 → XP_030106758.1 leucine zipper putative tumor suppressor 2 isoform X1

UniProtKB/Swiss-Prot

E9QKK6, Q569X6, Q91YU6

Conserved Domains (2) summary

pfam06818
Location:441 → 637

Fez1

pfam13851
Location:404 → 476

GAS; Growth-arrest specific micro-tubule binding
XM_030250899.2 → XP_030106759.1 leucine zipper putative tumor suppressor 2 isoform X1

UniProtKB/Swiss-Prot

E9QKK6, Q569X6, Q91YU6

Conserved Domains (2) summary

pfam06818
Location:441 → 637

Fez1

pfam13851
Location:404 → 476

GAS; Growth-arrest specific micro-tubule binding
XM_006527005.5 → XP_006527068.1 leucine zipper putative tumor suppressor 2 isoform X3

See identical proteins and their annotated locations for XP_006527068.1

Conserved Domains (2) summary

pfam06818
Location:220 → 416

Fez1

pfam13851
Location:183 → 255

GAS; Growth-arrest specific micro-tubule binding
XM_030250900.1 → XP_030106760.1 leucine zipper putative tumor suppressor 2 isoform X2

Conserved Domains (2) summary

pfam06818
Location:304 → 500

Fez1

pfam13851
Location:267 → 339

GAS; Growth-arrest specific micro-tubule binding