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MCRIP2 MAPK regulated corepressor interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 84331, updated on 23-Nov-2021

Summary

Official Symbol
MCRIP2provided by HGNC
Official Full Name
MAPK regulated corepressor interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:14142
See related
Ensembl:ENSG00000172366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM195A; C16orf14; c349E10.1
Expression
Ubiquitous expression in kidney (RPKM 20.5), duodenum (RPKM 19.9) and 24 other tissues See more
Orthologs
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Genomic context

See MCRIP2 in Genome Data Viewer
Location:
16p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (641828..648474)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (691828..698474)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100287175 Neighboring gene tRNA-Gly (anticodon CCC) 2-2 Neighboring gene uncharacterized LOC105371038 Neighboring gene WD repeat domain 90 Neighboring gene uncharacterized LOC107984861 Neighboring gene ras homolog family member T2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with family with sequence similarity 195, member A (FAM195A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC15416, MGC104301

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
MAPK regulated corepressor interacting protein 2
Names
MAPK regulated co-repressor interacting protein 2
family with sequence similarity 195, member A
protein FAM195A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331229.2NP_001318158.1  MAPK regulated corepressor interacting protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC001912, BM761884, BQ222343
    UniProtKB/Swiss-Prot
    Q9BUT9
    Conserved Domains (1) summary
    pfam14799
    Location:61123
    FAM195; FAM195 family
  2. NM_001331230.2NP_001318159.1  MAPK regulated corepressor interacting protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal in-frame segment compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC001912, BE727113, BM761884
    UniProtKB/Swiss-Prot
    Q9BUT9
  3. NM_138418.4NP_612427.2  MAPK regulated corepressor interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_612427.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC001912, BM761884
    Consensus CDS
    CCDS10415.1
    UniProtKB/Swiss-Prot
    Q9BUT9
    Related
    ENSP00000305138.4, ENST00000307650.9
    Conserved Domains (1) summary
    pfam14799
    Location:61157
    FAM195; FAM195 family

RNA

  1. NR_138604.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL022341
    Related
    ENST00000491999.5
  2. NR_138605.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL022341
  3. NR_138606.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC007346, BM761884
    Related
    ENST00000474840.5
  4. NR_138607.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC001912, BG489095, BM761884
  5. NR_138608.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC001912, BM761884, DT218216
  6. NR_138609.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL022341, BC001912, DB452069
  7. NR_138610.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AJ709169, BC001912
  8. NR_138611.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL022341
    Related
    ENST00000611328.4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    641828..648474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032371.2: Suppressed sequence

    Description
    NM_032371.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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