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MCRIP2 MAPK regulated corepressor interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 84331, updated on 5-Jul-2025
Official Symbol
MCRIP2provided by HGNC
Official Full Name
MAPK regulated corepressor interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:14142
See related
Ensembl:ENSG00000172366 AllianceGenome:HGNC:14142
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM195A; C16orf14; c349E10.1
Summary
Predicted to enable RNA binding activity. Predicted to act upstream of or within several processes, including carboxylic acid metabolic process; cold-induced thermogenesis; and response to cold. Located in cytoplasmic stress granule and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in kidney (RPKM 20.5), duodenum (RPKM 19.9) and 24 other tissues See more
Orthologs
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See MCRIP2 in Genome Data Viewer
Location:
16p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (641828..648474)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (645896..652542)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (691828..698474)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100287175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:687335-688109 Neighboring gene tRNA-Gly (anticodon CCC) 2-2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:690840-691751 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6931 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10210 Neighboring gene uncharacterized LOC105371038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:699402-700224 Neighboring gene WD repeat domain 90 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:709386-710276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:717843-718524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6937 Neighboring gene ras homolog family member T2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2. Wang Y, et al. Circulation, 2018 Jul 3. PMID 29453251
  2. Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins. Bish R, et al. Biomolecules, 2015 Jul 15. PMID 26184334, Free PMC Article
  3. Identification of genes related to Parkinson's disease using expressed sequence tags. Kim JM, et al. DNA Res, 2006 Dec 31. PMID 17213182
  4. The sequence and analysis of duplication-rich human chromosome 16. Martin J, et al. Nature, 2004 Dec 23. PMID 15616553
  5. The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation. Nelson CB, et al. Nat Commun, 2024 Feb 15. PMID 38360978, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel adipokine, FAM19A5, was capable of inhibiting postinjury neointima formation via sphingosine-1-phosphate receptor 2-G12/13-RhoA signaling.
    Title: Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with family with sequence similarity 195, member A (FAM195A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC15416, MGC104301

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within branched-chain amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cold-induced thermogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to cold IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
MAPK regulated corepressor interacting protein 2
Names
MAPK regulated co-repressor interacting protein 2
family with sequence similarity 195, member A
protein FAM195A

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331229.2 → NP_001318158.1  MAPK regulated corepressor interacting protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC001912, BM761884, BQ222343
    UniProtKB/Swiss-Prot
    Q9BUT9
    Conserved Domains (1) summary
    pfam14799
    Location:61 → 123
    FAM195; FAM195 family

  2. NM_001331230.2 → NP_001318159.1  MAPK regulated corepressor interacting protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal in-frame segment compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC001912, BE727113, BM761884
    UniProtKB/Swiss-Prot
    Q9BUT9

  3. NM_138418.4 → NP_612427.2  MAPK regulated corepressor interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_612427.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC001912, BM761884
    Consensus CDS
    CCDS10415.1
    UniProtKB/Swiss-Prot
    Q969E9, Q96KV8, Q9BUT9
    Related
    ENSP00000305138.4, ENST00000307650.9
    Conserved Domains (1) summary
    pfam14799
    Location:61 → 157
    FAM195; FAM195 family

RNA

  1. NR_138604.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL022341
    Related
    ENST00000491999.5

  2. NR_138605.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL022341

  3. NR_138606.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC007346, BM761884
    Related
    ENST00000474840.5

  4. NR_138607.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC001912, BG489095, BM761884

  5. NR_138608.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC001912, BM761884, DT218216

  6. NR_138609.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL022341, BC001912, DB452069

  7. NR_138610.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AJ709169, BC001912

  8. NR_138611.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL022341
    Related
    ENST00000611328.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    641828..648474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    645896..652542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032371.2: Suppressed sequence

    Description
    NM_032371.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BUT9.2 GenPept UniProtKB/Swiss-Prot:Q9BUT9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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