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HVCN1 hydrogen voltage gated channel 1 [ Homo sapiens (human) ]

Gene ID: 84329, updated on 25-Jan-2024

Summary

Official Symbol
HVCN1provided by HGNC
Official Full Name
hydrogen voltage gated channel 1provided by HGNC
Primary source
HGNC:HGNC:28240
See related
Ensembl:ENSG00000122986 MIM:611227; AllianceGenome:HGNC:28240
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HV1; VSOP
Summary
This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Expression
Broad expression in lymph node (RPKM 18.5), testis (RPKM 16.2) and 21 other tissues See more
Orthologs
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Genomic context

See HVCN1 in Genome Data Viewer
Location:
12q24.11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (110648686..110704952, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (110626380..110682642, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (111086491..111127582, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RAD9 checkpoint clamp component B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:110978258-110978758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:110978759-110979259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7008 Neighboring gene protein phosphatase targeting COQ7 Neighboring gene HNF4 motif-containing MPRA enhancer 250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7009 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4857 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7010 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7011 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7013 Neighboring gene RNA, 7SL, cytoplasmic 387, pseudogene Neighboring gene tectonic family member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:111099215-111099717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7016 Neighboring gene uncharacterized LOC124903017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:111124990-111125818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4859 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7026 Neighboring gene protein phosphatase 1 catalytic subunit gamma Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:111180421-111180929 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:111181691-111182275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7027 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:111218408-111218569 Neighboring gene CRISPRi-validated cis-regulatory element chr12.3641 Neighboring gene NANOG hESC enhancer GRCh37_chr12:111246997-111247498 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:111251419-111251918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7028 Neighboring gene ribosomal protein L29 pseudogene 25

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC15619

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables voltage-gated monoatomic cation channel activity EXP
Inferred from Experiment
more info
PubMed 
enables voltage-gated proton channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables voltage-gated proton channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables voltage-gated proton channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables voltage-gated proton channel activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in cell redox homeostasis TAS
Traceable Author Statement
more info
 
involved_in cellular response to pH IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to zinc ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular pH elevation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of superoxide anion generation IEA
Inferred from Electronic Annotation
more info
 
involved_in proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proton transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proton transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of acrosome reaction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of reactive oxygen species biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to pH ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in response to zinc ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to zinc ion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in phagocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
 
located_in specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
voltage-gated hydrogen channel 1
Names
voltage sensor domain-only protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040107.2NP_001035196.1  voltage-gated hydrogen channel 1 isoform 1

    See identical proteins and their annotated locations for NP_001035196.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter protein (isoform 1). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC144522, BP375483, DB310328
    Consensus CDS
    CCDS31900.1
    UniProtKB/Swiss-Prot
    A8MQ37, B4DEB3, F8WCH5, Q6UW11, Q96D96, Q96IS5
    UniProtKB/TrEMBL
    D2KFF9
    Conserved Domains (1) summary
    pfam16799
    Location:226273
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
  2. NM_001256413.2NP_001243342.1  voltage-gated hydrogen channel 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC144522, AK293543
    Consensus CDS
    CCDS58278.1
    UniProtKB/TrEMBL
    D2KFF9
    Related
    ENSP00000412052.2, ENST00000439744.6
    Conserved Domains (1) summary
    pfam16799
    Location:206253
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
  3. NM_032369.4NP_115745.2  voltage-gated hydrogen channel 1 isoform 1

    See identical proteins and their annotated locations for NP_115745.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC009731, BP369986, DB310328
    Consensus CDS
    CCDS31900.1
    UniProtKB/Swiss-Prot
    A8MQ37, B4DEB3, F8WCH5, Q6UW11, Q96D96, Q96IS5
    UniProtKB/TrEMBL
    D2KFF9
    Related
    ENSP00000242607.8, ENST00000242607.13
    Conserved Domains (1) summary
    pfam16799
    Location:226273
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    110648686..110704952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538846.3XP_011537148.1  voltage-gated hydrogen channel 1 isoform X2

    See identical proteins and their annotated locations for XP_011537148.1

    UniProtKB/Swiss-Prot
    A8MQ37, B4DEB3, F8WCH5, Q6UW11, Q96D96, Q96IS5
    UniProtKB/TrEMBL
    D2KFF9
    Conserved Domains (1) summary
    pfam16799
    Location:226273
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
  2. XM_017020026.3XP_016875515.1  voltage-gated hydrogen channel 1 isoform X1

    UniProtKB/TrEMBL
    D2KFF9
    Conserved Domains (1) summary
    pfam16799
    Location:273320
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
  3. XM_011538847.2XP_011537149.1  voltage-gated hydrogen channel 1 isoform X2

    See identical proteins and their annotated locations for XP_011537149.1

    UniProtKB/Swiss-Prot
    A8MQ37, B4DEB3, F8WCH5, Q6UW11, Q96D96, Q96IS5
    UniProtKB/TrEMBL
    D2KFF9
    Conserved Domains (1) summary
    pfam16799
    Location:226273
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
  4. XM_024449225.2XP_024304993.1  voltage-gated hydrogen channel 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MQ37, B4DEB3, F8WCH5, Q6UW11, Q96D96, Q96IS5
    UniProtKB/TrEMBL
    D2KFF9
    Conserved Domains (1) summary
    pfam16799
    Location:226273
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
  5. XM_011538842.3XP_011537144.1  voltage-gated hydrogen channel 1 isoform X1

    See identical proteins and their annotated locations for XP_011537144.1

    UniProtKB/TrEMBL
    D2KFF9
    Conserved Domains (1) summary
    pfam16799
    Location:273320
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
  6. XM_011538839.3XP_011537141.1  voltage-gated hydrogen channel 1 isoform X1

    See identical proteins and their annotated locations for XP_011537141.1

    UniProtKB/TrEMBL
    D2KFF9
    Conserved Domains (1) summary
    pfam16799
    Location:273320
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
  7. XM_005253948.3XP_005254005.1  voltage-gated hydrogen channel 1 isoform X2

    See identical proteins and their annotated locations for XP_005254005.1

    UniProtKB/Swiss-Prot
    A8MQ37, B4DEB3, F8WCH5, Q6UW11, Q96D96, Q96IS5
    UniProtKB/TrEMBL
    D2KFF9
    Conserved Domains (1) summary
    pfam16799
    Location:226273
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
  8. XM_011538840.4XP_011537142.1  voltage-gated hydrogen channel 1 isoform X1

    See identical proteins and their annotated locations for XP_011537142.1

    UniProtKB/TrEMBL
    D2KFF9
    Conserved Domains (1) summary
    pfam16799
    Location:273320
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
  9. XM_017020027.2XP_016875516.1  voltage-gated hydrogen channel 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MQ37, B4DEB3, F8WCH5, Q6UW11, Q96D96, Q96IS5
    UniProtKB/TrEMBL
    D2KFF9
    Conserved Domains (1) summary
    pfam16799
    Location:226273
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
  10. XM_011538844.3XP_011537146.1  voltage-gated hydrogen channel 1 isoform X1

    See identical proteins and their annotated locations for XP_011537146.1

    UniProtKB/TrEMBL
    D2KFF9
    Conserved Domains (1) summary
    pfam16799
    Location:273320
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
  11. XM_011538845.3XP_011537147.1  voltage-gated hydrogen channel 1 isoform X2

    See identical proteins and their annotated locations for XP_011537147.1

    UniProtKB/Swiss-Prot
    A8MQ37, B4DEB3, F8WCH5, Q6UW11, Q96D96, Q96IS5
    UniProtKB/TrEMBL
    D2KFF9
    Related
    ENSP00000449601.1, ENST00000548312.5
    Conserved Domains (1) summary
    pfam16799
    Location:226273
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
  12. XM_011538841.3XP_011537143.1  voltage-gated hydrogen channel 1 isoform X1

    See identical proteins and their annotated locations for XP_011537143.1

    UniProtKB/TrEMBL
    D2KFF9
    Conserved Domains (1) summary
    pfam16799
    Location:273320
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
  13. XM_011538838.3XP_011537140.1  voltage-gated hydrogen channel 1 isoform X1

    See identical proteins and their annotated locations for XP_011537140.1

    UniProtKB/TrEMBL
    D2KFF9
    Conserved Domains (1) summary
    pfam16799
    Location:273320
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
  14. XM_047429670.1XP_047285626.1  voltage-gated hydrogen channel 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MQ37, B4DEB3, F8WCH5, Q6UW11, Q96D96, Q96IS5
    UniProtKB/TrEMBL
    D2KFF9
  15. XM_047429669.1XP_047285625.1  voltage-gated hydrogen channel 1 isoform X1

    UniProtKB/TrEMBL
    D2KFF9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    110626380..110682642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373483.1XP_054229458.1  voltage-gated hydrogen channel 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MQ37, B4DEB3, F8WCH5, Q6UW11, Q96D96, Q96IS5
    UniProtKB/TrEMBL
    D2KFF9
  2. XM_054373476.1XP_054229451.1  voltage-gated hydrogen channel 1 isoform X1

    UniProtKB/TrEMBL
    D2KFF9
  3. XM_054373479.1XP_054229454.1  voltage-gated hydrogen channel 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MQ37, B4DEB3, F8WCH5, Q6UW11, Q96D96, Q96IS5
    UniProtKB/TrEMBL
    D2KFF9
  4. XM_054373482.1XP_054229457.1  voltage-gated hydrogen channel 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MQ37, B4DEB3, F8WCH5, Q6UW11, Q96D96, Q96IS5
    UniProtKB/TrEMBL
    D2KFF9
  5. XM_054373475.1XP_054229450.1  voltage-gated hydrogen channel 1 isoform X1

    UniProtKB/TrEMBL
    D2KFF9
  6. XM_054373471.1XP_054229446.1  voltage-gated hydrogen channel 1 isoform X1

    UniProtKB/TrEMBL
    D2KFF9
  7. XM_054373481.1XP_054229456.1  voltage-gated hydrogen channel 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MQ37, B4DEB3, F8WCH5, Q6UW11, Q96D96, Q96IS5
    UniProtKB/TrEMBL
    D2KFF9
  8. XM_054373474.1XP_054229449.1  voltage-gated hydrogen channel 1 isoform X1

    UniProtKB/TrEMBL
    D2KFF9
  9. XM_054373477.1XP_054229452.1  voltage-gated hydrogen channel 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MQ37, B4DEB3, F8WCH5, Q6UW11, Q96D96, Q96IS5
    UniProtKB/TrEMBL
    D2KFF9
  10. XM_054373472.1XP_054229447.1  voltage-gated hydrogen channel 1 isoform X1

    UniProtKB/TrEMBL
    D2KFF9
  11. XM_054373478.1XP_054229453.1  voltage-gated hydrogen channel 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MQ37, B4DEB3, F8WCH5, Q6UW11, Q96D96, Q96IS5
    UniProtKB/TrEMBL
    D2KFF9
  12. XM_054373473.1XP_054229448.1  voltage-gated hydrogen channel 1 isoform X1

    UniProtKB/TrEMBL
    D2KFF9
  13. XM_054373470.1XP_054229445.1  voltage-gated hydrogen channel 1 isoform X1

    UniProtKB/TrEMBL
    D2KFF9
  14. XM_054373480.1XP_054229455.1  voltage-gated hydrogen channel 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MQ37, B4DEB3, F8WCH5, Q6UW11, Q96D96, Q96IS5
    UniProtKB/TrEMBL
    D2KFF9