U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hvcn1 hydrogen voltage-gated channel 1 [ Mus musculus (house mouse) ]

Gene ID: 74096, updated on 5-Mar-2024

Summary

Official Symbol
Hvcn1provided by MGI
Official Full Name
hydrogen voltage-gated channel 1provided by MGI
Primary source
MGI:MGI:1921346
See related
Ensembl:ENSMUSG00000064267 AllianceGenome:MGI:1921346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BTS; HV1; Vsop.; mVSOP; 0610039P13Rik
Summary
Enables identical protein binding activity and voltage-gated proton channel activity. Involved in response to pH and response to zinc ion. Acts upstream of or within proton transmembrane transport. Predicted to be located in apical plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human HVCN1 (hydrogen voltage gated channel 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 61.0), mammary gland adult (RPKM 25.5) and 17 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Hvcn1 in Genome Data Viewer
Location:
5 F; 5 62.23 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122344872..122380360)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122206805..122242297)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14271 Neighboring gene myosin, light polypeptide 2, regulatory, cardiac, slow Neighboring gene coiled-coil domain containing 63 Neighboring gene STARR-positive B cell enhancer ABC_E3613 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122595403-122595586 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122595588-122595697 Neighboring gene protein phosphatase 1 catalytic subunit gamma Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122634438-122634667 Neighboring gene STARR-seq mESC enhancer starr_14277 Neighboring gene STARR-positive B cell enhancer ABC_E9650 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122685188-122685492 Neighboring gene tectonic family member 1 Neighboring gene STARR-positive B cell enhancer ABC_E6375 Neighboring gene STARR-positive B cell enhancer ABC_E10345 Neighboring gene RIKEN cDNA 1700112N08 gene Neighboring gene STARR-seq mESC enhancer starr_14278 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122738438-122738621 Neighboring gene PTC7 protein phosphatase homolog Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122760748-122760949 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122761679-122761976 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122767369-122767570 Neighboring gene RAD9 checkpoint clamp component B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated proton channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables voltage-gated proton channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables voltage-gated proton channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to pH ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to zinc ion ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular pH elevation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
involved_in proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within proton transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proton transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of acrosome reaction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of intracellular pH ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to pH IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to zinc ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to zinc ion ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IC
Inferred by Curator
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
voltage-gated hydrogen channel 1
Names
voltage sensor domain-only protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042489.2NP_001035954.1  voltage-gated hydrogen channel 1

    See identical proteins and their annotated locations for NP_001035954.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AC127266, AK002854, CF734112, CF749152
    Consensus CDS
    CCDS19644.1
    UniProtKB/Swiss-Prot
    Q3U2S8, Q9DCE4
    Related
    ENSMUSP00000072401.8, ENSMUST00000072602.14
    Conserved Domains (2) summary
    pfam16799
    Location:222269
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
    pfam00520
    Location:125191
    Ion_trans; Ion transport protein
  2. NM_001359454.1NP_001346383.1  voltage-gated hydrogen channel 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC127266
    Consensus CDS
    CCDS19644.1
    UniProtKB/Swiss-Prot
    Q3U2S8, Q9DCE4
    Conserved Domains (2) summary
    pfam16799
    Location:222269
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
    pfam00520
    Location:125191
    Ion_trans; Ion transport protein
  3. NM_028752.3NP_083028.1  voltage-gated hydrogen channel 1

    See identical proteins and their annotated locations for NP_083028.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC127266, AK002854
    Consensus CDS
    CCDS19644.1
    UniProtKB/Swiss-Prot
    Q3U2S8, Q9DCE4
    Related
    ENSMUSP00000098312.3, ENSMUST00000100747.3
    Conserved Domains (2) summary
    pfam16799
    Location:222269
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
    pfam00520
    Location:125191
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    122344872..122380360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530472.4XP_006530535.1  voltage-gated hydrogen channel 1 isoform X2

    See identical proteins and their annotated locations for XP_006530535.1

    UniProtKB/Swiss-Prot
    Q3U2S8, Q9DCE4
    Conserved Domains (2) summary
    pfam16799
    Location:222269
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
    pfam00520
    Location:125191
    Ion_trans; Ion transport protein
  2. XM_006530471.5XP_006530534.1  voltage-gated hydrogen channel 1 isoform X1

    Conserved Domains (2) summary
    pfam16799
    Location:226273
    VGPC1_C; C-terminal membrane-localization domain of ion-channel, VCN1
    pfam00520
    Location:129195
    Ion_trans; Ion transport protein