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THOC3 THO complex 3 [ Homo sapiens (human) ]

Gene ID: 84321, updated on 1-Jun-2020

Summary

Official Symbol
THOC3provided by HGNC
Official Full Name
THO complex 3provided by HGNC
Primary source
HGNC:HGNC:19072
See related
Ensembl:ENSG00000051596 MIM:606929
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
THO3; hTREX45
Summary
This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the transcription export complex is recruited to the 5'-end of messenger RNAs in a splicing- and cap-dependent manner. Studies of a related complex in mouse suggest that the metazoan transcription export complex is involved in cell differentiation and development. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, May 2013]
Expression
Ubiquitous expression in esophagus (RPKM 29.0), testis (RPKM 21.2) and 24 other tissues See more
Orthologs

Genomic context

See THOC3 in Genome Data Viewer
Location:
5q35.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (175959531..176034905, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (175386534..175395318, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377744 Neighboring gene complexin 2 Neighboring gene uncharacterized LOC107986485 Neighboring gene uncharacterized LOC107986486 Neighboring gene THOC3 antisense RNA 1 Neighboring gene olfactory receptor family 1 subfamily X member 1 pseudogene Neighboring gene uncharacterized LOC105377746 Neighboring gene uncharacterized LOC100996385 Neighboring gene PLCR-B recombination region Neighboring gene family with sequence similarity 153 member B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5469

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA export from nucleus TAS
Traceable Author Statement
more info
 
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
mRNA 3'-end processing TAS
Traceable Author Statement
more info
 
mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
viral mRNA export from host cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
THO complex part of transcription export complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription export complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
THO complex subunit 3
Names
TEX1 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376902.1NP_001363831.1  THO complex subunit 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC138965
    Related
    ENSP00000422243.1, ENST00000513482.1
  2. NM_032361.4NP_115737.1  THO complex subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_115737.1

    Status: REVIEWED

    Source sequence(s)
    AC138965
    Consensus CDS
    CCDS4397.1
    UniProtKB/Swiss-Prot
    Q96J01
    Related
    ENSP00000265097.4, ENST00000265097.8
    Conserved Domains (2) summary
    cd00200
    Location:49290
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5997
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    175959531..176034905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009985.1XP_016865474.1  THO complex subunit 3 isoform X1

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