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Thoc3 THO complex 3 [ Mus musculus (house mouse) ]

Gene ID: 73666, updated on 30-Apr-2024

Summary

Official Symbol
Thoc3provided by MGI
Official Full Name
THO complex 3provided by MGI
Primary source
MGI:MGI:1920916
See related
Ensembl:ENSMUSG00000025872 AllianceGenome:MGI:1920916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410044K02Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA export from nucleus and viral mRNA export from host cell nucleus. Predicted to act upstream of or within RNA splicing; mRNA processing; and mRNA transport. Predicted to be located in nucleus. Predicted to be part of THO complex part of transcription export complex. Predicted to colocalize with chromosome, telomeric region. Orthologous to human THOC3 (THO complex 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 21.8), CNS E14 (RPKM 12.9) and 28 other tissues See more
Orthologs
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Genomic context

See Thoc3 in Genome Data Viewer
Location:
13 B1; 13 28.69 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54606650..54616653, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54458837..54468840, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40955 Neighboring gene predicted gene, 48622 Neighboring gene STARR-positive B cell enhancer ABC_E5398 Neighboring gene complexin 2 Neighboring gene STARR-positive B cell enhancer ABC_E11782 Neighboring gene STARR-positive B cell enhancer ABC_E7240 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:54548428-54548615 Neighboring gene STARR-positive B cell enhancer ABC_E10794 Neighboring gene STARR-positive B cell enhancer ABC_E7241 Neighboring gene predicted gene, 53205 Neighboring gene predicted gene 2830 Neighboring gene SUMO-interacting motifs containing 1 Neighboring gene RIKEN cDNA 4833439L19 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of THO complex part of transcription export complex ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of transcription export complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
THO complex subunit 3
Names
tho3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028597.3NP_082873.2  THO complex subunit 3

    See identical proteins and their annotated locations for NP_082873.2

    Status: VALIDATED

    Source sequence(s)
    AC165145
    Consensus CDS
    CCDS26527.1
    UniProtKB/Swiss-Prot
    Q8VE80, Q9CWI8
    Related
    ENSMUSP00000026990.6, ENSMUST00000026990.6
    Conserved Domains (3) summary
    COG2319
    Location:46329
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:49290
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5997
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    54606650..54616653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)