Thoc3 THO complex 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Thoc3provided by MGI
Official Full Name: THO complex 3provided by MGI
Primary source: MGI:MGI:1920916
See related: Ensembl:ENSMUSG00000025872 AllianceGenome:MGI:1920916
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2410044K02Rik
Summary: Predicted to enable RNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be located in nuclear speck. Predicted to be part of THO complex part of transcription export complex. Predicted to colocalize with chromosome, telomeric region. Is expressed in brain. Orthologous to human THOC3 (THO complex subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 21.8), CNS E14 (RPKM 12.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 28.69 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (54606650..54616653, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (54458837..54468840, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of THO complex part of transcription export complex	IBA Inferred from Biological aspect of Ancestor more info
part_of THO complex part of transcription export complex	IEA Inferred from Electronic Annotation more info
part_of THO complex part of transcription export complex	ISO Inferred from Sequence Orthology more info
part_of THO complex part of transcription export complex	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
colocalizes_with chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription export complex	IEA Inferred from Electronic Annotation more info
part_of transcription export complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: THO complex subunit 3

Names: tho3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028597.3 → NP_082873.2 THO complex subunit 3

See identical proteins and their annotated locations for NP_082873.2

Status: VALIDATED

Source sequence(s)

AC165145

Consensus CDS

CCDS26527.1

UniProtKB/Swiss-Prot

Q8VE80, Q9CWI8

Related

ENSMUSP00000026990.6, ENSMUST00000026990.6

Conserved Domains (3) summary

COG2319
Location:46 → 329

WD40; WD40 repeat [General function prediction only]

cd00200
Location:49 → 290

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:59 → 97

7WD40; WD40 repeat [structural motif]