ETR1 Signal transduction histidine kinase, hybrid-type, ethylene sensor [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: ETR1
Official Full Name: Signal transduction histidine kinase, hybrid-type, ethylene sensor
Primary source: TAIR:AT1G66340
Locus tag: AT1G66340
See related: Araport:AT1G66340
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtETR1; EIN1; ETHYLENE INSENSITIVE 1; ETHYLENE RESPONSE; ETHYLENE RESPONSE 1; ETR; HISTIDINE KINASE ETR1; T27F4.9; T27F4_9
Summary: Similar to prokaryote sensory transduction proteins. Contains a histidine kinase and a response regulator domain. Homodimer. Membrane component. Binds ethylene. Mutations affect ethylene binding and metabolism of other plant hormones such as auxin, cytokinins, ABA and gibberellic acid. Ethylene receptor. Has histidine kinase activity. Is regulated by RTE1. Mutations in ETR1 block ethylene stimulation of flavonol synthesis.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See ETR1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 7

Sequence:: Chromosome: 1; NC_003070.9 (24734162..24737756)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Basis for high-affinity ethylene binding by the ethylene receptor ETR1 of Arabidopsis.
Title: Basis for high-affinity ethylene binding by the ethylene receptor ETR1 of Arabidopsis.
Ethylene-Insensitive Arabidopsis Mutants etr1-1 and ein2-1 Have a Decreased Freezing Tolerance
Title: Ethylene-Insensitive Arabidopsis Mutants etr1-1 and ein2-1 Have a Decreased Freezing Tolerance.
ETR1 and ETR2 have both ethylene-dependent and -independent roles in plant cells that affect responses to abscissic acid.
Title: Ethylene Receptors Signal via a Noncanonical Pathway to Regulate Abscisic Acid Responses.
ETR1-receiver domain already exists as an active formation and executes its function through binding with the downstream factors without phosphorylation.
Title: NMR Study Reveals the Receiver Domain of Arabidopsis ETHYLENE RESPONSE1 Ethylene Receptor as an Atypical Type Response Regulator.
The ETR1 receiver domain has multiple functions where different surfaces are involved in the control of different traits.
Title: Identification of Regions in the Receiver Domain of the ETHYLENE RESPONSE1 Ethylene Receptor of Arabidopsis Important for Functional Divergence.
ERS1-regulated expression of a subset of ethylene-responsive genes is related to controlling the magnitude of ethylene response.
Title: Dominant gain-of-function mutations in transmembrane domain III of ERS1 and ETR1 suggest a novel role for this domain in regulating the magnitude of ethylene response in Arabidopsis.
Galpha mediates ethylene-induced stomatal closure via H2O2 production, and acts downstream of RAN1, ETR1, ERS1, EIN4 and CTR1 and upstream of EIN2, EIN3 and ARR2. The data also show that ETR1 and ERS1 mediate both ethylene and H2O2 signalling in guard cells.
Title: Heterotrimeric G protein mediates ethylene-induced stomatal closure via hydrogen peroxide synthesis in Arabidopsis.
ETR1, ETR2, and ETHYLENE INSENSITIVE4 (EIN4) have the prominent roles in rapid growth recovery after removal of ethylene whereas ETR1 was the sole isoform that rescued nutations.
Title: Ethylene receptor ETHYLENE RECEPTOR1 domain requirements for ethylene responses in Arabidopsis seedlings.
Data show that the cytosolic domain of ETR1 plays a key role, interacting with all other receptors and several participants of the ethylene signaling pathway.
Title: Structural model of the cytosolic domain of the plant ethylene receptor 1 (ETR1).
Cb5 and RTE1 are functional partners in promoting ETR1-mediated repression of ethylene signaling.
Title: Association of cytochrome b5 with ETR1 ethylene receptor signaling through RTE1 in Arabidopsis.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

NM_105305.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ethylene binding	IDA Inferred from Direct Assay more info	PubMed
enables ethylene receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphorelay sensor kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein histidine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein histidine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein histidine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytokinin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within defense response by callose deposition in cell wall	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of ethylene stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hydrogen peroxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within jasmonic acid and ethylene-dependent systemic resistance, ethylene mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of ethylene-activated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within phloem or xylem histogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of seedling development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of stomatal movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to auxin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ethylene	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to gibberellin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to insect	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to molecule of bacterial origin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to salt stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within seed dormancy process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sugar mediated signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: Signal transduction histidine kinase, hybrid-type, ethylene sensor

NP_176808.3

ETHYLENE RESPONSE 1 (ETR1); CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, homodimeric (InterPro:IPR009082), Signal transduction histidine kinase, core (InterPro:IPR005467), Signal transduction histidine kinase, hybrid-type, ethylene sensor (InterPro:IPR014525), ATPase-like, ATP-binding domain (InterPro:IPR003594), CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789), Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain (InterPro:IPR003661), GAF (InterPro:IPR003018), Signal transduction histidine kinase-related protein, C-terminal (InterPro:IPR004358); BEST Arabidopsis thaliana protein match is: ethylene response sensor 1 (TAIR:AT2G40940.1); Has 102721 Blast hits to 98263 proteins in 3046 species: Archae - 757; Bacteria - 90102; Metazoa - 18; Fungi - 1611; Plants - 2314; Viruses - 21; Other Eukaryotes - 7898 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

24734162..24737756

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_105305.4 → NP_176808.3 Signal transduction histidine kinase, hybrid-type, ethylene sensor [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_176808.3

Status: REVIEWED

UniProtKB/Swiss-Prot

P49333

UniProtKB/TrEMBL

A0A5S9WSS5

Conserved Domains (4) summary

smart00387
Location:455 → 581

HATPase_c; Histidine kinase-like ATPases

smart00388
Location:343 → 408

HisKA; His Kinase A (phosphoacceptor) domain

cd00156
Location:613 → 729

REC; Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; ...

pfam01590
Location:158 → 307

GAF; GAF domain