Format

Send to:

Choose Destination

PRXL2A peroxiredoxin like 2A [ Homo sapiens (human) ]

Gene ID: 84293, updated on 21-Dec-2019

Summary

Official Symbol
PRXL2Aprovided by HGNC
Official Full Name
peroxiredoxin like 2Aprovided by HGNC
Primary source
HGNC:HGNC:28651
See related
Ensembl:ENSG00000122378 MIM:617165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Adrx; PAMM; FAM213A; C10orf58
Expression
Broad expression in fat (RPKM 75.6), brain (RPKM 14.4) and 16 other tissues See more
Orthologs

Genomic context

See PRXL2A in Genome Data Viewer
Location:
10q23.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (80407829..80437115)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (82167585..82192753)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 519 pseudogene 1 Neighboring gene DPY30 domain containing 1 Neighboring gene DPY30 domain containing 2 Neighboring gene tetraspanin 14 Neighboring gene uncharacterized LOC101929574 Neighboring gene SH2 domain containing 4B Neighboring gene uncharacterized LOC105378387

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4248, FLJ12536, FLJ14952, FLJ44312

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antioxidant activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
antioxidant activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
peroxiredoxin-like 2A
Names
Adiporedoxin
UPF0765 protein C10orf58
family with sequence similarity 213 member A
peroxiredoxin (PRX)-like 2 activated in M-CSF stimulated monocytes
peroxiredoxin-like 2 activated in M-CSF stimulated monocytes
redox-regulatory protein FAM213A
redox-regulatory protein PAMM

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243778.1NP_001230707.1  peroxiredoxin-like 2A isoform 1 precursor

    See identical proteins and their annotated locations for NP_001230707.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AA829725, AL359195, BC005871
    Consensus CDS
    CCDS7368.1
    UniProtKB/Swiss-Prot
    Q9BRX8
    Related
    ENSP00000361261.5, ENST00000372187.9
    Conserved Domains (1) summary
    cd02970
    Location:48201
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
  2. NM_001243779.1NP_001230708.1  peroxiredoxin-like 2A isoform 1 precursor

    See identical proteins and their annotated locations for NP_001230708.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1)
    Source sequence(s)
    AA829725, AF305824, BC005871, BE742158
    Consensus CDS
    CCDS7368.1
    UniProtKB/Swiss-Prot
    Q9BRX8
    Related
    ENSP00000361262.1, ENST00000372188.5
    Conserved Domains (1) summary
    cd02970
    Location:48201
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
  3. NM_001243780.1NP_001230709.1  peroxiredoxin-like 2A isoform 1 precursor

    See identical proteins and their annotated locations for NP_001230709.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AA829725, BC024308, DB494833
    Consensus CDS
    CCDS7368.1
    UniProtKB/Swiss-Prot
    Q9BRX8
    Related
    ENSP00000478152.1, ENST00000615554.4
    Conserved Domains (1) summary
    cd02970
    Location:48201
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
  4. NM_001243781.2NP_001230710.1  peroxiredoxin-like 2A isoform 2 precursor

    See identical proteins and their annotated locations for NP_001230710.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA829725, AC021028, AK075447, BC005871
    Consensus CDS
    CCDS58089.1
    UniProtKB/Swiss-Prot
    Q9BRX8
    Related
    ENSP00000361259.1, ENST00000372185.5
    Conserved Domains (1) summary
    cd02970
    Location:37190
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
  5. NM_001243782.2NP_001230711.1  peroxiredoxin-like 2A isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, uses an alternate splice site and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AA829725, AC021028, AL359195, BC005871, CN396006
    UniProtKB/Swiss-Prot
    Q9BRX8
    Conserved Domains (1) summary
    cd02970
    Location:44197
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
  6. NM_032333.5NP_115709.3  peroxiredoxin-like 2A isoform 1 precursor

    See identical proteins and their annotated locations for NP_115709.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, 3 and 4 encode the same isoform.
    Source sequence(s)
    AA829725, AC021028, AI589570, AK074643, BC071938
    Consensus CDS
    CCDS7368.1
    UniProtKB/Swiss-Prot
    Q9BRX8
    Related
    ENSP00000482445.1, ENST00000606162.6
    Conserved Domains (1) summary
    cd02970
    Location:48201
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    80407829..80437115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540266.2XP_011538568.1  peroxiredoxin-like 2A isoform X2

    See identical proteins and their annotated locations for XP_011538568.1

    UniProtKB/Swiss-Prot
    Q9BRX8
    Conserved Domains (1) summary
    cd02970
    Location:48201
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
  2. XM_017016775.1XP_016872264.1  peroxiredoxin-like 2A isoform X1

  3. XM_011540265.2XP_011538567.1  peroxiredoxin-like 2A isoform X2

    See identical proteins and their annotated locations for XP_011538567.1

    UniProtKB/Swiss-Prot
    Q9BRX8
    Conserved Domains (1) summary
    cd02970
    Location:48201
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
Support Center