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ZDHHC16 zinc finger DHHC-type palmitoyltransferase 16 [ Homo sapiens (human) ]

Gene ID: 84287, updated on 7-Jun-2020

Summary

Official Symbol
ZDHHC16provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 16provided by HGNC
Primary source
HGNC:HGNC:20714
See related
Ensembl:ENSG00000171307 MIM:616750
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APH2; DHHC-16
Expression
Ubiquitous expression in placenta (RPKM 10.0), lung (RPKM 9.7) and 25 other tissues See more
Orthologs

Genomic context

See ZDHHC16 in Genome Data Viewer
Location:
10q24.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (97446131..97457370)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99205900..99217127)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene phosphoglycerate mutase 1 Neighboring gene exosome component 1 Neighboring gene MMS19 homolog, cytosolic iron-sulfur assembly component Neighboring gene ubiquitin domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2993

Gene Ontology Provided by GOA

Function Evidence Code Pubs
palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
eye development ISS
Inferred from Sequence or Structural Similarity
more info
 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
protein palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
telencephalon development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC16
Names
Abl-philin 2
probable palmitoyltransferase ZDHHC16
zinc finger DHHC domain-containing protein 16
zinc finger DHHC-type containing 16
zinc finger, DHHC domain containing 16
NP_001274732.1
NP_001274733.1
NP_115703.2
NP_932160.1
NP_932161.1
NP_932162.1
NP_932163.1
XP_006718084.1
XP_006718085.1
XP_006718086.1
XP_006718087.1
XP_006718088.1
XP_006718089.1
XP_016872255.1
XP_016872256.1
XP_016872257.1
XP_016872258.1
XP_016872259.1
XP_016872260.1
XP_016872261.1
XP_016872262.1
XP_016872263.1
XP_024304001.1
XP_024304002.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287803.1NP_001274732.1  palmitoyltransferase ZDHHC16 isoform 5 precursor

    See identical proteins and their annotated locations for NP_001274732.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 3' coding region, compared to variant 5. It encodes isoform 5, which is shorter than isoform 1.
    Source sequence(s)
    AK297962, BC008074, BM678689, DC399731
    UniProtKB/Swiss-Prot
    Q969W1
    UniProtKB/TrEMBL
    B4DNL2
    Conserved Domains (1) summary
    pfam01529
    Location:155287
    zf-DHHC; DHHC palmitoyltransferase
  2. NM_001287804.1NP_001274733.1  palmitoyltransferase ZDHHC16 isoform 6 precursor

    See identical proteins and their annotated locations for NP_001274733.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks three exons in the central and 3' coding regions and uses an alternate in-frame splice site in the 3' coding region, compared to variant 5. It encodes isoform 6, which is shorter than isoform 1.
    Source sequence(s)
    BC008074, BC033157, BM678689, BX353685, DC399731
    Consensus CDS
    CCDS73176.1
    UniProtKB/Swiss-Prot
    Q969W1
    UniProtKB/TrEMBL
    B1AMU0
    Related
    ENSP00000359883.4, ENST00000370846.8
    Conserved Domains (1) summary
    cl19890
    Location:126185
    zf-DHHC; DHHC palmitoyltransferase
  3. NM_032327.3NP_115703.2  palmitoyltransferase ZDHHC16 isoform 1 precursor

    See identical proteins and their annotated locations for NP_115703.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 5. Variants 1 and 5 encode the same isoform (1), which is the longest isoform.
    Source sequence(s)
    BC012830, BM678689, DC399731
    Consensus CDS
    CCDS7460.1
    UniProtKB/Swiss-Prot
    Q969W1
    Related
    ENSP00000359891.3, ENST00000370854.7
    Conserved Domains (1) summary
    pfam01529
    Location:156305
    zf-DHHC; DHHC palmitoyltransferase
  4. NM_198043.2NP_932160.1  palmitoyltransferase ZDHHC16 isoform 2 precursor

    See identical proteins and their annotated locations for NP_932160.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 5. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AF258563, BM678689, DC399731
    Consensus CDS
    CCDS7461.1
    UniProtKB/Swiss-Prot
    Q969W1
    Related
    ENSP00000345383.4, ENST00000352634.8
    Conserved Domains (1) summary
    pfam01529
    Location:155289
    zf-DHHC; DHHC palmitoyltransferase
  5. NM_198044.2NP_932161.1  palmitoyltransferase ZDHHC16 isoform 3 precursor

    See identical proteins and their annotated locations for NP_932161.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and lacks an alternate exon and uses an alternate in-frame splice site in the 5' coding region, compared to variant 5. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    BC033157, BM678689, DC399731
    Consensus CDS
    CCDS7462.1
    UniProtKB/Swiss-Prot
    Q969W1
    Related
    ENSP00000323360.3, ENST00000353979.7
    Conserved Domains (1) summary
    cl19890
    Location:126175
    zf-DHHC; DHHC palmitoyltransferase
  6. NM_198045.2NP_932162.1  palmitoyltransferase ZDHHC16 isoform 4 precursor

    See identical proteins and their annotated locations for NP_932162.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons, one in the 5' coding region and the other in the 3' coding region, compared to variant 5. It encodes isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    BC004535, DC399731
    Consensus CDS
    CCDS7463.1
    UniProtKB/Swiss-Prot
    Q969W1
    Related
    ENSP00000304487.8, ENST00000345745.9
    Conserved Domains (1) summary
    pfam01529
    Location:91224
    zf-DHHC; DHHC palmitoyltransferase
  7. NM_198046.3NP_932163.1  palmitoyltransferase ZDHHC16 isoform 1 precursor

    See identical proteins and their annotated locations for NP_932163.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents the longest transcript. Variants 1 and 5 encode the same isoform (1), which is the longest isoform.
    Source sequence(s)
    AJ294945, AK297962, BM678689, DC399731
    Consensus CDS
    CCDS7460.1
    UniProtKB/Swiss-Prot
    Q969W1
    UniProtKB/TrEMBL
    B4DNL2
    Related
    ENSP00000377357.1, ENST00000393760.6
    Conserved Domains (1) summary
    pfam01529
    Location:156305
    zf-DHHC; DHHC palmitoyltransferase

RNA

  1. NR_109895.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks three internal exons and uses an alternate splice site in an internal exon, compared to variant 5. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 5z.
    Source sequence(s)
    BC004535, BG769550, DC399731

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    97446131..97457370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718021.1XP_006718084.1  palmitoyltransferase ZDHHC16 isoform X1

    See identical proteins and their annotated locations for XP_006718084.1

    Conserved Domains (1) summary
    pfam01529
    Location:155312
    zf-DHHC; DHHC palmitoyltransferase
  2. XM_006718024.1XP_006718087.1  palmitoyltransferase ZDHHC16 isoform X4

    See identical proteins and their annotated locations for XP_006718087.1

    UniProtKB/TrEMBL
    B4DNL2
    Related
    ENSP00000396286.1, ENST00000417044.1
    Conserved Domains (1) summary
    pfam01529
    Location:155287
    zf-DHHC; DHHC palmitoyltransferase
  3. XM_006718023.1XP_006718086.1  palmitoyltransferase ZDHHC16 isoform X2

    Conserved Domains (1) summary
    pfam01529
    Location:155296
    zf-DHHC; DHHC palmitoyltransferase
  4. XM_017016767.1XP_016872256.1  palmitoyltransferase ZDHHC16 isoform X6

    Related
    ENSP00000405240.1, ENST00000420089.5
  5. XM_006718025.1XP_006718088.1  palmitoyltransferase ZDHHC16 isoform X5

    Conserved Domains (1) summary
    cl19890
    Location:126175
    zf-DHHC; DHHC palmitoyltransferase
  6. XM_006718026.1XP_006718089.1  palmitoyltransferase ZDHHC16 isoform X8

    Conserved Domains (1) summary
    cl19890
    Location:155257
    zf-DHHC; DHHC palmitoyltransferase
  7. XM_017016769.1XP_016872258.1  palmitoyltransferase ZDHHC16 isoform X9

  8. XM_017016770.1XP_016872259.1  palmitoyltransferase ZDHHC16 isoform X10

  9. XM_024448233.1XP_024304001.1  palmitoyltransferase ZDHHC16 isoform X11

    Conserved Domains (1) summary
    pfam01529
    Location:91240
    zf-DHHC; DHHC palmitoyltransferase
  10. XM_017016772.1XP_016872261.1  palmitoyltransferase ZDHHC16 isoform X13

  11. XM_017016773.1XP_016872262.1  palmitoyltransferase ZDHHC16 isoform X14

  12. XM_017016774.1XP_016872263.1  palmitoyltransferase ZDHHC16 isoform X15

    Conserved Domains (1) summary
    pfam01529
    Location:1125
    zf-DHHC; DHHC palmitoyltransferase
  13. XM_006718022.1XP_006718085.1  palmitoyltransferase ZDHHC16 isoform X1

    See identical proteins and their annotated locations for XP_006718085.1

    Conserved Domains (1) summary
    pfam01529
    Location:155312
    zf-DHHC; DHHC palmitoyltransferase
  14. XM_017016766.1XP_016872255.1  palmitoyltransferase ZDHHC16 isoform X3

    UniProtKB/Swiss-Prot
    Q969W1
    Conserved Domains (1) summary
    pfam01529
    Location:155289
    zf-DHHC; DHHC palmitoyltransferase
  15. XM_017016771.1XP_016872260.1  palmitoyltransferase ZDHHC16 isoform X12

    UniProtKB/TrEMBL
    B1AMU0
    Conserved Domains (1) summary
    cl19890
    Location:126185
    zf-DHHC; DHHC palmitoyltransferase
  16. XM_017016768.1XP_016872257.1  palmitoyltransferase ZDHHC16 isoform X7

    UniProtKB/Swiss-Prot
    Q969W1
    Conserved Domains (1) summary
    cl19890
    Location:126175
    zf-DHHC; DHHC palmitoyltransferase
  17. XM_024448234.1XP_024304002.1  palmitoyltransferase ZDHHC16 isoform X15

    Related
    ENST00000495735.5
    Conserved Domains (1) summary
    pfam01529
    Location:1125
    zf-DHHC; DHHC palmitoyltransferase

RNA

  1. XR_001747231.1 RNA Sequence

  2. XR_001747232.1 RNA Sequence

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