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Zdhhc16 zinc finger, DHHC domain containing 16 [ Mus musculus (house mouse) ]

Gene ID: 74168, updated on 8-May-2024

Summary

Official Symbol
Zdhhc16provided by MGI
Official Full Name
zinc finger, DHHC domain containing 16provided by MGI
Primary source
MGI:MGI:1921418
See related
Ensembl:ENSMUSG00000025157 AllianceGenome:MGI:1921418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aph2; 1500015N03Rik
Summary
Enables palmitoyltransferase activity. Involved in animal organ development; cellular response to DNA damage stimulus; and protein palmitoylation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in early conceptus; eye; genitourinary system; heart; and trunk somite. Orthologous to human ZDHHC16 (zinc finger DHHC-type palmitoyltransferase 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 18.4), ovary adult (RPKM 16.7) and 28 other tissues See more
Orthologs
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Genomic context

See Zdhhc16 in Genome Data Viewer
Location:
19 C3; 19 35.48 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (41921884..41932543)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (41933445..41944104)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7659 Neighboring gene phosphoglycerate mutase 1 Neighboring gene exosome component 1 Neighboring gene STARR-positive B cell enhancer ABC_E3252 Neighboring gene MMS19 cytosolic iron-sulfur assembly component Neighboring gene STARR-positive B cell enhancer ABC_E1524 Neighboring gene predicted gene, 23113 Neighboring gene ubiquitin domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_46168 Neighboring gene STARR-seq mESC enhancer starr_46171

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC16
Names
Abl-philin 2
ablphilin-2
probable palmitoyltransferase ZDHHC16
zinc finger DHHC domain-containing protein 16
NP_001347605.1
NP_001347608.1
NP_076229.2
XP_006527467.1
XP_006527468.1
XP_006527469.1
XP_006527470.1
XP_017173789.1
XP_030106976.1
XP_030106977.1
XP_030106978.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360676.1NP_001347605.1  palmitoyltransferase ZDHHC16 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140193
    Conserved Domains (1) summary
    pfam01529
    Location:156305
    DHHC; DHHC palmitoyltransferase
  2. NM_001360679.1NP_001347608.1  palmitoyltransferase ZDHHC16 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC140193
    Conserved Domains (1) summary
    pfam01529
    Location:1109
    DHHC; DHHC palmitoyltransferase
  3. NM_023740.3NP_076229.2  palmitoyltransferase ZDHHC16 isoform 2

    See identical proteins and their annotated locations for NP_076229.2

    Status: VALIDATED

    Source sequence(s)
    AK151505, BY634308, CK619221, DV658063
    Consensus CDS
    CCDS29817.1
    UniProtKB/Swiss-Prot
    Q3TI22, Q3UA59, Q91XC5, Q9ESG8
    Related
    ENSMUSP00000026154.8, ENSMUST00000026154.9
    Conserved Domains (1) summary
    pfam01529
    Location:156289
    DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    41921884..41932543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527406.4XP_006527469.1  palmitoyltransferase ZDHHC16 isoform X4

    See identical proteins and their annotated locations for XP_006527469.1

    Conserved Domains (1) summary
    pfam01529
    Location:1125
    DHHC; DHHC palmitoyltransferase
  2. XM_006527407.4XP_006527470.1  palmitoyltransferase ZDHHC16 isoform X4

    See identical proteins and their annotated locations for XP_006527470.1

    Conserved Domains (1) summary
    pfam01529
    Location:1125
    DHHC; DHHC palmitoyltransferase
  3. XM_030251118.2XP_030106978.1  palmitoyltransferase ZDHHC16 isoform X5

    Conserved Domains (1) summary
    pfam01529
    Location:1109
    DHHC; DHHC palmitoyltransferase
  4. XM_017318300.3XP_017173789.1  palmitoyltransferase ZDHHC16 isoform X1

    Conserved Domains (1) summary
    pfam01529
    Location:156305
    DHHC; DHHC palmitoyltransferase
  5. XM_030251117.2XP_030106977.1  palmitoyltransferase ZDHHC16 isoform X2

    Conserved Domains (1) summary
    pfam01529
    Location:156289
    DHHC; DHHC palmitoyltransferase
  6. XM_006527404.5XP_006527467.1  palmitoyltransferase ZDHHC16 isoform X1

    Conserved Domains (1) summary
    pfam01529
    Location:156305
    DHHC; DHHC palmitoyltransferase
  7. XM_030251116.2XP_030106976.1  palmitoyltransferase ZDHHC16 isoform X2

    Conserved Domains (1) summary
    pfam01529
    Location:156289
    DHHC; DHHC palmitoyltransferase
  8. XM_006527405.5XP_006527468.1  palmitoyltransferase ZDHHC16 isoform X3

    Conserved Domains (1) summary
    cl19890
    Location:156194
    DHHC; DHHC palmitoyltransferase