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COQ5 coenzyme Q5, methyltransferase [ Homo sapiens (human) ]

Gene ID: 84274, updated on 20-Dec-2019

Summary

Official Symbol
COQ5provided by HGNC
Official Full Name
coenzyme Q5, methyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:28722
See related
Ensembl:ENSG00000110871 MIM:616359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in kidney (RPKM 15.5), liver (RPKM 13.7) and 25 other tissues See more
Orthologs

Genomic context

See COQ5 in Genome Data Viewer
Location:
12q24.31
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (120503279..120534613, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120941082..120966964, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene glutamyl-tRNA amidotransferase subunit C Neighboring gene serine and arginine rich splicing factor 9 Neighboring gene dynein light chain LC8-type 1 Neighboring gene uncharacterized LOC107987181 Neighboring gene negative regulator of antiviral response Neighboring gene ribosomal protein L29 pseudogene 24 Neighboring gene ring finger protein 10 Neighboring gene POP5 homolog, ribonuclease P/MRP subunit Neighboring gene ribosomal protein L11 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4767, MGC104303

Gene Ontology Provided by GOA

Function Evidence Code Pubs
2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
methylation IDA
Inferred from Direct Assay
more info
PubMed 
ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
ubiquinone biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
extrinsic component of mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
Names
coenzyme Q5 homolog, methyltransferase
ubiquinone biosynthesis methyltransferase COQ5, mitochondrial
NP_115690.3
XP_006719702.1
XP_024304992.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032314.4NP_115690.3  2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_115690.3

    Status: VALIDATED

    Source sequence(s)
    AK222610, BC107874, BP307378
    Consensus CDS
    CCDS31912.1
    UniProtKB/Swiss-Prot
    Q5HYK3
    Related
    ENSP00000288532.6, ENST00000288532.11
    Conserved Domains (1) summary
    PRK00216
    Location:56327
    ubiE; ubiquinone/menaquinone biosynthesis methyltransferase; Reviewed

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    120503279..120534613 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449224.1XP_024304992.1  2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial isoform X1

    Conserved Domains (1) summary
    PRK00216
    Location:1246
    ubiE; ubiquinone/menaquinone biosynthesis methyltransferase; Reviewed
  2. XM_006719639.2XP_006719702.1  2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial isoform X1

    Related
    ENSP00000449863.1, ENST00000552443.5
    Conserved Domains (1) summary
    PRK00216
    Location:1246
    ubiE; ubiquinone/menaquinone biosynthesis methyltransferase; Reviewed
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