U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Coq5 coenzyme Q5 methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 52064, updated on 1-Mar-2024

Summary

Official Symbol
Coq5provided by MGI
Official Full Name
coenzyme Q5 methyltransferaseprovided by MGI
Primary source
MGI:MGI:1098643
See related
Ensembl:ENSMUSG00000041733 AllianceGenome:MGI:1098643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D5Ertd33e; 1810014G04Rik
Summary
Predicted to enable 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity. Predicted to be involved in methylation and ubiquinone biosynthetic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 9. Orthologous to human COQ5 (coenzyme Q5, methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 22.2), cerebellum adult (RPKM 9.6) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Coq5 in Genome Data Viewer
Location:
5 F; 5 56.03 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115417752..115435029)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115279666..115296974)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8072 Neighboring gene processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae) Neighboring gene ring finger protein 10 Neighboring gene STARR-seq mESC enhancer starr_14112 Neighboring gene STARR-positive B cell enhancer ABC_E3605 Neighboring gene STARR-seq mESC enhancer starr_14114 Neighboring gene STARR-positive B cell enhancer ABC_E530 Neighboring gene dynein light chain LC8-type 1 Neighboring gene predicted gene 13830

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ubiquinone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquinone biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquinone biosynthesis complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
Names
coenzyme Q5 homolog, methyltransferase
ubiquinone biosynthesis methyltransferase COQ5, mitochondrial
NP_080780.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026504.3NP_080780.1  2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_080780.1

    Status: VALIDATED

    Source sequence(s)
    AC145070
    Consensus CDS
    CCDS19585.1
    UniProtKB/Swiss-Prot
    Q9CXI0, Q9D6Y6, Q9D900
    Related
    ENSMUSP00000048001.5, ENSMUST00000040421.11
    Conserved Domains (1) summary
    PRK00216
    Location:56327
    ubiE; ubiquinone/menaquinone biosynthesis methyltransferase; Reviewed

RNA

  1. NR_184540.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC145070

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    115417752..115435029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)