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CARD19 caspase recruitment domain family member 19 [ Homo sapiens (human) ]

Gene ID: 84270, updated on 31-Dec-2019

Summary

Official Symbol
CARD19provided by HGNC
Official Full Name
caspase recruitment domain family member 19provided by HGNC
Primary source
HGNC:HGNC:28148
See related
Ensembl:ENSG00000165233 MIM:617726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BinCARD; C9orf89
Expression
Ubiquitous expression in bone marrow (RPKM 13.5), testis (RPKM 6.7) and 24 other tissues See more
Orthologs

Genomic context

See CARD19 in Genome Data Viewer
Location:
9q22.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (93096217..93113283)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (95858450..95875565)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12079 Neighboring gene sushi domain containing 3 Neighboring gene uncharacterized LOC101927993 Neighboring gene ninjurin 1 Neighboring gene WNK lysine deficient protein kinase 2 Neighboring gene chromosome 9 open reading frame 129

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC11115, MGC110898

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CARD domain binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
negative regulation of I-kappaB kinase/NF-kappaB signaling NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol NAS
Non-traceable Author Statement
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
caspase recruitment domain-containing protein 19
Names
Bcl10-interacting protein with CARD
bcl10-interacting CARD protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318010.2NP_001304939.1  caspase recruitment domain-containing protein 19 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks two alternate exons in the coding region, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL451065, DB550397, DN998463, HY005780
    Conserved Domains (1) summary
    cl14633
    Location:1050
    DD; Death Domain Superfamily of protein-protein interaction domains
  2. NM_001318011.2NP_001304940.1  caspase recruitment domain-containing protein 19 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AA804861, BM930683, HY005780
    Conserved Domains (1) summary
    cd13785
    Location:1095
    CARD_BinCARD_like; BinCARD (Bcl10-interacting protein with CARD)
  3. NM_032310.5NP_115686.3  caspase recruitment domain-containing protein 19 isoform 1

    See identical proteins and their annotated locations for NP_115686.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL451065, BC004500, DB550397, HY005780
    Consensus CDS
    CCDS6702.2
    UniProtKB/Swiss-Prot
    Q96LW7
    UniProtKB/TrEMBL
    A0A024R248
    Related
    ENSP00000364613.2, ENST00000375464.7
    Conserved Domains (1) summary
    cd13785
    Location:1095
    CARD_BinCARD_like; BinCARD (Bcl10-interacting protein with CARD)

RNA

  1. NR_134464.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and retains two introns, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK091611, AL451065, BC038856, DB550397, HY005780
  2. NR_134465.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) retains two introns, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL451065, BC038856, DB550397, HY005780
    Related
    ENST00000466409.1
  3. NR_134466.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL451065, BC091476, DB550397, HY005780
    Related
    ENST00000490488.5
  4. NR_134467.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA804861, BC004500, BX354102, HY005780
  5. NR_134468.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA804861, CD676329, HY005780
    Related
    ENST00000468781.5
  6. NR_160511.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL451065
  7. NR_160512.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL451065
  8. NR_160513.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL451065

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    93096217..93113283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_929848.2 RNA Sequence

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