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Card19 caspase recruitment domain family, member 19 [ Mus musculus (house mouse) ]

Gene ID: 68480, updated on 26-Sep-2022

Summary

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Official Symbol
Card19provided by MGI
Official Full Name
caspase recruitment domain family, member 19provided by MGI
Primary source
MGI:MGI:1915730
See related
Ensembl:ENSMUSG00000037960 AllianceGenome:MGI:1915730
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bincard; 1110007C09Rik
Summary
Predicted to be involved in regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Orthologous to human CARD19 (caspase recruitment domain family member 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 84.9), stomach adult (RPKM 82.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Card19 in Genome Data Viewer
Location:
13; 13 A5
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49356426..49369543, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49202950..49216068, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40943 Neighboring gene ninjurin 1 Neighboring gene predicted gene, 52024 Neighboring gene sushi domain containing 3 Neighboring gene RIKEN cDNA E030007A22 gene Neighboring gene FYVE, RhoGEF and PH domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CARD19 Interacts with Mitochondrial Contact Site and Cristae Organizing System Constituent Proteins and Regulates Cristae Morphology. Rios KE, et al. Cells, 2022 Mar 31. PMID 35406738, Free PMC Article
  2. CARD19, the protein formerly known as BinCARD, is a mitochondrial protein that does not regulate Bcl10-dependent NF-κB activation after TCR engagement. Rios KE, et al. Cell Immunol, 2020 Oct. PMID 32763502, Free PMC Article
  3. Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection. Bjanes E, et al. PLoS Pathog, 2021 Oct. PMID 34648590, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (17) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CARD19 Interacts with Mitochondrial Contact Site and Cristae Organizing System Constituent Proteins and Regulates Cristae Morphology.
    Title: CARD19 Interacts with Mitochondrial Contact Site and Cristae Organizing System Constituent Proteins and Regulates Cristae Morphology.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
caspase recruitment domain-containing protein 19
Names
Bcl10-interacting protein with Card
bcl10-interacting CARD protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026738.2 → NP_081014.1  caspase recruitment domain-containing protein 19

    See identical proteins and their annotated locations for NP_081014.1

    Status: PROVISIONAL

    Source sequence(s)
    AK003526
    Consensus CDS
    CCDS49260.1
    UniProtKB/Swiss-Prot
    Q3U3Y9, Q9D1I2
    UniProtKB/TrEMBL
    A0A6P5QWU3, A0A8C6IBD9, B2RV71
    Related
    ENSMUSP00000047569.7, ENSMUST00000048946.7
    Conserved Domains (1) summary
    cd13785
    Location:10 → 95
    CARD_BinCARD_like; BinCARD (Bcl10-interacting protein with CARD)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    49356426..49369543 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516955.5 → XP_006517018.1  caspase recruitment domain-containing protein 19 isoform X1

    UniProtKB/TrEMBL
    A0A6P5QZA2
    Conserved Domains (1) summary
    cd13785
    Location:10 → 95
    CARD_BinCARD_like; BinCARD (Bcl10-interacting protein with CARD)

RNA

  1. XR_003950472.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D1I2.1 GenPept UniProtKB/Swiss-Prot:Q9D1I2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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