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FLYWCH1 FLYWCH-type zinc finger 1 [ Homo sapiens (human) ]

Gene ID: 84256, updated on 4-Jul-2021

Summary

Official Symbol
FLYWCH1provided by HGNC
Official Full Name
FLYWCH-type zinc finger 1provided by HGNC
Primary source
HGNC:HGNC:25404
See related
Ensembl:ENSG00000059122
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in spleen (RPKM 6.6), ovary (RPKM 5.2) and 25 other tissues See more
Orthologs
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Genomic context

See FLYWCH1 in Genome Data Viewer
Location:
16p13.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (2911873..2951208)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2961932..3001209)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929566 Neighboring gene FLYWCH family member 2 Neighboring gene ribosomal protein L23a pseudogene 86 Neighboring gene uncharacterized LOC105371055 Neighboring gene kringle containing transmembrane protein 2 Neighboring gene progestin and adipoQ receptor family member 4 Neighboring gene protein kinase, membrane associated tyrosine/threonine 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
FLYWCH-type zinc finger-containing protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308068.2NP_001294997.1  FLYWCH-type zinc finger-containing protein 1 isoform c

    See identical proteins and their annotated locations for NP_001294997.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region compared to variant 1. The encoded isoform (c) is longer than isoform a.
    Source sequence(s)
    AC004034, AC004234, AC004235
    Consensus CDS
    CCDS76809.1
    UniProtKB/Swiss-Prot
    Q4VC44
    Related
    ENSP00000253928.9, ENST00000253928.14
    Conserved Domains (3) summary
    pfam04500
    Location:273331
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:332420
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
  2. NM_020912.2NP_065963.1  FLYWCH-type zinc finger-containing protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the C-terminus compared to isoform a.
    Source sequence(s)
    AC004034, AC004234
    UniProtKB/Swiss-Prot
    Q4VC44
    Conserved Domains (3) summary
    pfam04500
    Location:272330
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:331419
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
  3. NM_032296.3NP_115672.2  FLYWCH-type zinc finger-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_115672.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (a).
    Source sequence(s)
    AC004034, AC004234, AC004235
    Consensus CDS
    CCDS45390.1
    UniProtKB/Swiss-Prot
    Q4VC44
    Related
    ENSP00000399938.2, ENST00000416288.6
    Conserved Domains (3) summary
    pfam04500
    Location:272330
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:331419
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    2911873..2951208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522707.2XP_011521009.1  FLYWCH-type zinc finger-containing protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011521009.1

    Conserved Domains (3) summary
    pfam04500
    Location:273331
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:332420
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
  2. XM_017023772.1XP_016879261.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

    Conserved Domains (3) summary
    pfam04500
    Location:273331
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:332420
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
  3. XM_011522703.2XP_011521005.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011521005.1

    Conserved Domains (3) summary
    pfam04500
    Location:273331
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:332420
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
  4. XM_011522704.2XP_011521006.1  FLYWCH-type zinc finger-containing protein 1 isoform X2

    Conserved Domains (3) summary
    pfam04500
    Location:272330
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:331419
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
  5. XM_011522701.2XP_011521003.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011521003.1

    Conserved Domains (3) summary
    pfam04500
    Location:273331
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:332420
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
  6. XM_011522705.2XP_011521007.1  FLYWCH-type zinc finger-containing protein 1 isoform X3

    Conserved Domains (3) summary
    pfam04500
    Location:273331
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:332420
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
  7. XM_006720962.3XP_006721025.1  FLYWCH-type zinc finger-containing protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006721025.1

    UniProtKB/Swiss-Prot
    Q4VC44
    Conserved Domains (3) summary
    pfam04500
    Location:273331
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:332420
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
  8. XM_011522702.2XP_011521004.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011521004.1

    Conserved Domains (3) summary
    pfam04500
    Location:273331
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:332420
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1

RNA

  1. XR_001752002.1 RNA Sequence

  2. XR_001752003.2 RNA Sequence

  3. XR_001752004.1 RNA Sequence

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