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Flywch1 FLYWCH-type zinc finger 1 [ Mus musculus (house mouse) ]

Gene ID: 224613, updated on 30-Apr-2024

Summary

Official Symbol
Flywch1provided by MGI
Official Full Name
FLYWCH-type zinc finger 1provided by MGI
Primary source
MGI:MGI:2442638
See related
Ensembl:ENSMUSG00000040097 AllianceGenome:MGI:2442638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1552; E030034P13Rik
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be located in cytosol and nuclear body. Is expressed in adrenal gland; cartilage; genitourinary system; nervous system; and neural retina. Orthologous to human FLYWCH1 (FLYWCH-type zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 34.9), testis adult (RPKM 26.7) and 25 other tissues See more
Orthologs
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Genomic context

See Flywch1 in Genome Data Viewer
Location:
17 A3.3; 17 12.04 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23971767..23993504, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23752795..23774530, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene protein kinase, membrane associated tyrosine/threonine 1 Neighboring gene progestin and adipoQ receptor family member IV Neighboring gene RIKEN cDNA 9530082P21 gene Neighboring gene kringle containing transmembrane protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E4197 Neighboring gene FLYWCH family member 2 Neighboring gene predicted gene, 52285 Neighboring gene serine/arginine repetitive matrix 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of pericentric heterochromatin ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
FLYWCH-type zinc finger-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357993.1NP_001344922.1  FLYWCH-type zinc finger-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122821, AI849618
    UniProtKB/TrEMBL
    A0A2I3BRL2
    Conserved Domains (3) summary
    pfam04500
    Location:235293
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:183
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:294351
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
  2. NM_001357994.1NP_001344923.1  FLYWCH-type zinc finger-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122821, AI849618
    UniProtKB/TrEMBL
    A0A2I3BRL2
    Related
    ENSMUSP00000154618.2, ENSMUST00000227120.2
    Conserved Domains (3) summary
    pfam04500
    Location:235293
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:183
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:294351
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
  3. NM_153791.2NP_722486.2  FLYWCH-type zinc finger-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_722486.2

    Status: VALIDATED

    Source sequence(s)
    AK168389, BY128897, CA321280, CD553578
    Consensus CDS
    CCDS28463.1
    UniProtKB/Swiss-Prot
    E9QKQ2, Q3TH83, Q6ZPN0, Q8C792, Q8CI03
    UniProtKB/TrEMBL
    A0A2I3BRL2
    Related
    ENSMUSP00000083505.6, ENSMUST00000086325.13
    Conserved Domains (3) summary
    pfam04500
    Location:235293
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:183
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:294401
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    23971767..23993504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524082.5XP_006524145.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006524145.1

    UniProtKB/TrEMBL
    A0A2I3BRL2
    Conserved Domains (3) summary
    pfam04500
    Location:235293
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:183
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:294351
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
  2. XM_006524083.5XP_006524146.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006524146.1

    UniProtKB/TrEMBL
    A0A2I3BRL2
    Conserved Domains (3) summary
    pfam04500
    Location:235293
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:183
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:294351
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1