HEI10 RING/U-box superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: HEI10
Gene description: RING/U-box superfamily protein
Primary source: Araport:AT1G53490
Locus tag: AT1G53490
See related: TAIR:AT1G53490
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F22G10.16; homolog of human HEI10 ( Enhancer of cell Invasion No.10)
Summary: Encodes HEI10, a RING finger-containing protein. HEI10 belongs to a group of proteins well conserved among species known as ZMM. Required for class I crossover formation.
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Genomic context

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See HEI10 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 10

Sequence:: Chromosome: 1; NC_003070.9 (19963267..19966952)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HEI10 is subject to phase separation and mediates RPA1a degradation during meiotic interference-sensitive crossover formation.
Title: HEI10 is subject to phase separation and mediates RPA1a degradation during meiotic interference-sensitive crossover formation.
Diffusion-mediated HEI10 coarsening can explain meiotic crossover positioning in Arabidopsis.
Title: Diffusion-mediated HEI10 coarsening can explain meiotic crossover positioning in Arabidopsis.
HEI10 protein is present as numerous foci on chromosome axes during early meiotic prophase and is retained until the end of prophase at a limited number of sites corresponding to crossovers. HEI10 is structurally and functionally related to the yeast Zip3 ZMM and that it is absolutely required for class I crossover formation in Arabidopsis thaliana. [HEI10]
Title: The Arabidopsis HEI10 is a new ZMM protein related to Zip3.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001333596.1

Supported by ESTs:

NM_104227.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chiasma assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chiasma	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: RING/U-box superfamily protein

NP_175754.2

RING/U-box superfamily protein; Has 175 Blast hits to 173 proteins in 83 species: Archae - 2; Bacteria - 14; Metazoa - 69; Fungi - 24; Plants - 38; Viruses - 0; Other Eukaryotes - 28 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

19963267..19966952

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_104227.2 → NP_175754.2 RING/U-box superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_175754.2

Status: REVIEWED

UniProtKB/Swiss-Prot

F4HRI2, Q9C8L1, Q9LPG5

UniProtKB/TrEMBL

A0A178W8Z0

Conserved Domains (2) summary

pfam10158
Location:106 → 173

LOH1CR12; Tumour suppressor protein

pfam14634
Location:2 → 43

zf-RING_5; zinc-RING finger domain
NM_001333596.1 → NP_001321879.1 RING/U-box superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178W7F3, A0A1P8AS84