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SLC41A2 solute carrier family 41 member 2 [ Homo sapiens (human) ]

Gene ID: 84102, updated on 12-Oct-2019

Summary

Official Symbol
SLC41A2provided by HGNC
Official Full Name
solute carrier family 41 member 2provided by HGNC
Primary source
HGNC:HGNC:31045
See related
Ensembl:ENSG00000136052 MIM:610802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLC41A1-L1
Expression
Broad expression in liver (RPKM 11.3), duodenum (RPKM 5.8) and 20 other tissues See more
Orthologs

Genomic context

See SLC41A2 in Genome Data Viewer
Location:
12q23.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (104802553..104958744, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (105196331..105352476, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 11 Neighboring gene microRNA 3922 Neighboring gene uncharacterized LOC112268100 Neighboring gene uncharacterized LOC105369950 Neighboring gene uncharacterized LOC105369952 Neighboring gene keratin 18 pseudogene 20 Neighboring gene chromosome 12 open reading frame 45

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC125330, MGC125331, DKFZp434K0427

Gene Ontology Provided by GOA

Function Evidence Code Pubs
divalent inorganic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
divalent metal ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 41 member 2
Names
SLC41A1-like 1
solute carrier family 41 (magnesium transporter), member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001352169.1NP_001339098.1  solute carrier family 41 member 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC089985, AC090051
    Consensus CDS
    CCDS9100.2
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter
  2. NM_001352170.2NP_001339099.1  solute carrier family 41 member 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC089985, AC090051
    Consensus CDS
    CCDS9100.2
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter
  3. NM_001352171.2NP_001339100.1  solute carrier family 41 member 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC089985, AC090051
    Consensus CDS
    CCDS9100.2
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter
  4. NM_001352172.2NP_001339101.1  solute carrier family 41 member 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC089985, AC090051
    Consensus CDS
    CCDS9100.2
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter
  5. NM_032148.5NP_115524.3  solute carrier family 41 member 2

    See identical proteins and their annotated locations for NP_115524.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AC089985, AC090051
    Consensus CDS
    CCDS9100.2
    UniProtKB/Swiss-Prot
    Q96JW4
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    104802553..104958744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020013.1XP_016875502.1  solute carrier family 41 member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q96JW4
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter
  2. XM_011538808.1XP_011537110.1  solute carrier family 41 member 2 isoform X1

    See identical proteins and their annotated locations for XP_011537110.1

    UniProtKB/Swiss-Prot
    Q96JW4
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter
  3. XM_011538810.2XP_011537112.1  solute carrier family 41 member 2 isoform X1

    See identical proteins and their annotated locations for XP_011537112.1

    UniProtKB/Swiss-Prot
    Q96JW4
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter
  4. XM_024449219.1XP_024304987.1  solute carrier family 41 member 2 isoform X1

    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter
  5. XM_017020014.1XP_016875503.1  solute carrier family 41 member 2 isoform X2

    Conserved Domains (1) summary
    pfam01769
    Location:200331
    MgtE; Divalent cation transporter
  6. XM_005269179.1XP_005269236.1  solute carrier family 41 member 2 isoform X1

    See identical proteins and their annotated locations for XP_005269236.1

    UniProtKB/Swiss-Prot
    Q96JW4
    Related
    ENSP00000258538.3, ENST00000258538.7
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter
  7. XM_011538811.2XP_011537113.1  solute carrier family 41 member 2 isoform X1

    See identical proteins and their annotated locations for XP_011537113.1

    UniProtKB/Swiss-Prot
    Q96JW4
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter
  8. XM_017020016.2XP_016875505.1  solute carrier family 41 member 2 isoform X4

  9. XM_011538813.2XP_011537115.1  solute carrier family 41 member 2 isoform X6

    Conserved Domains (1) summary
    pfam01769
    Location:188328
    MgtE; Divalent cation transporter
  10. XM_017020017.1XP_016875506.1  solute carrier family 41 member 2 isoform X5

  11. XM_017020015.1XP_016875504.1  solute carrier family 41 member 2 isoform X3

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