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SLC41A2 solute carrier family 41 member 2 [ Homo sapiens (human) ]

Gene ID: 84102, updated on 8-Jul-2021

Summary

Official Symbol
SLC41A2provided by HGNC
Official Full Name
solute carrier family 41 member 2provided by HGNC
Primary source
HGNC:HGNC:31045
See related
Ensembl:ENSG00000136052 MIM:610802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLC41A1-L1
Expression
Broad expression in liver (RPKM 11.3), duodenum (RPKM 5.8) and 20 other tissues See more
Orthologs
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Genomic context

See SLC41A2 in Genome Data Viewer
Location:
12q23.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (104801801..104958746, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (105195579..105352524, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 11 Neighboring gene microRNA 3922 Neighboring gene uncharacterized LOC112268100 Neighboring gene uncharacterized LOC105369950 Neighboring gene uncharacterized LOC105369952 Neighboring gene keratin 18 pseudogene 20 Neighboring gene NOP protein chaperone 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC125330, MGC125331, DKFZp434K0427

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables magnesium ion transmembrane transporter activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in magnesium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 41 member 2
Names
SLC41A1-like 1
solute carrier family 41 (magnesium transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001352169.2NP_001339098.1  solute carrier family 41 member 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
    Source sequence(s)
    AC089985, AC090051
    Consensus CDS
    CCDS9100.2
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter
  2. NM_001352170.3NP_001339099.1  solute carrier family 41 member 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
    Source sequence(s)
    AC089985, AC090051
    Consensus CDS
    CCDS9100.2
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter
  3. NM_001352171.3NP_001339100.1  solute carrier family 41 member 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
    Source sequence(s)
    AC089985, AC090051
    Consensus CDS
    CCDS9100.2
    Related
    ENSP00000258538.3, ENST00000258538.8
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter
  4. NM_001352172.3NP_001339101.1  solute carrier family 41 member 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
    Source sequence(s)
    AC089985, AC090051
    Consensus CDS
    CCDS9100.2
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter
  5. NM_001387125.1NP_001374054.1  solute carrier family 41 member 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
    Source sequence(s)
    AC089985, AC090051
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter
  6. NM_001387126.1NP_001374055.1  solute carrier family 41 member 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
    Source sequence(s)
    AC089985, AC090051
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter
  7. NM_001387127.1NP_001374056.1  solute carrier family 41 member 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
    Source sequence(s)
    AC089985, AC090051
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter
  8. NM_001387128.1NP_001374057.1  solute carrier family 41 member 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 10 and 11, encodes isoform b.
    Source sequence(s)
    AC089985, AC090051
    Conserved Domains (1) summary
    pfam01769
    Location:200332
    MgtE; Divalent cation transporter
  9. NM_001387129.1NP_001374058.1  solute carrier family 41 member 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 9 and 11, encodes isoform b.
    Source sequence(s)
    AC089985, AC090051
    Conserved Domains (1) summary
    pfam01769
    Location:200332
    MgtE; Divalent cation transporter
  10. NM_001387130.1NP_001374059.1  solute carrier family 41 member 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 9 and 10, encodes isoform b.
    Source sequence(s)
    AC089985, AC090051
    Conserved Domains (1) summary
    pfam01769
    Location:200332
    MgtE; Divalent cation transporter
  11. NM_001387131.1NP_001374060.1  solute carrier family 41 member 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 13 and 14, encodes isoform c.
    Source sequence(s)
    AC089985, AC090051
    Conserved Domains (1) summary
    pfam01769
    Location:200332
    MgtE; Divalent cation transporter
  12. NM_001387132.1NP_001374061.1  solute carrier family 41 member 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 12 and 14, encodes isoform c.
    Source sequence(s)
    AC089985, AC090051
    Conserved Domains (1) summary
    pfam01769
    Location:200332
    MgtE; Divalent cation transporter
  13. NM_001387133.1NP_001374062.1  solute carrier family 41 member 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 12 and 13, encodes isoform c.
    Source sequence(s)
    AC089985, AC090051
    Conserved Domains (1) summary
    pfam01769
    Location:200332
    MgtE; Divalent cation transporter
  14. NM_032148.6NP_115524.3  solute carrier family 41 member 2 isoform a

    See identical proteins and their annotated locations for NP_115524.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-8 all encode the same isoform (a).
    Source sequence(s)
    AC089985, AC090051
    Consensus CDS
    CCDS9100.2
    UniProtKB/Swiss-Prot
    Q96JW4
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    104801801..104958746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020013.1XP_016875502.1  solute carrier family 41 member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q96JW4
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter
  2. XM_017020014.1XP_016875503.1  solute carrier family 41 member 2 isoform X2

    Conserved Domains (1) summary
    pfam01769
    Location:200332
    MgtE; Divalent cation transporter
  3. XM_005269179.1XP_005269236.1  solute carrier family 41 member 2 isoform X1

    See identical proteins and their annotated locations for XP_005269236.1

    UniProtKB/Swiss-Prot
    Q96JW4
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter
  4. XM_011538811.2XP_011537113.1  solute carrier family 41 member 2 isoform X1

    See identical proteins and their annotated locations for XP_011537113.1

    UniProtKB/Swiss-Prot
    Q96JW4
    Conserved Domains (1) summary
    pfam01769
    Location:414555
    MgtE; Divalent cation transporter
  5. XM_017020016.2XP_016875505.1  solute carrier family 41 member 2 isoform X4

  6. XM_011538813.2XP_011537115.1  solute carrier family 41 member 2 isoform X6

    Conserved Domains (1) summary
    pfam01769
    Location:188328
    MgtE; Divalent cation transporter
  7. XM_017020017.1XP_016875506.1  solute carrier family 41 member 2 isoform X5

  8. XM_017020015.1XP_016875504.1  solute carrier family 41 member 2 isoform X3

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