U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Plvap plasmalemma vesicle associated protein [ Mus musculus (house mouse) ]

Gene ID: 84094, updated on 3-Jan-2023

Summary

Official Symbol
Plvapprovided by MGI
Official Full Name
plasmalemma vesicle associated proteinprovided by MGI
Primary source
MGI:MGI:1890497
See related
Ensembl:ENSMUSG00000034845 AllianceGenome:MGI:1890497
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pv1; MECA32
Summary
Predicted to enable identical protein binding activity. Involved in developmental process and positive regulation of cellular extravasation. Predicted to be located in cell surface. Predicted to be integral component of membrane. Predicted to be active in caveola. Is expressed in several structures, including cardiovascular system; genitourinary system; liver; spleen; and trophectoderm. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human PLVAP (plasmalemma vesicle associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 563.9), adrenal adult (RPKM 272.0) and 12 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Plvap in Genome Data Viewer
Location:
8 B3.3; 8 34.43 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71950397..71964446, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71497753..71511806, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L34 Neighboring gene DET1 and DDB1 associated 1 Neighboring gene anoctamin 8 Neighboring gene GTP binding protein 3 Neighboring gene coiled-coil domain containing 194 Neighboring gene 14-3-3 protein sigma-like Neighboring gene bone marrow stromal cell antigen 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in developmental process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cellular extravasation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cellular extravasation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cellular extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of vascular permeability IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with caveola ISO
Inferred from Sequence Orthology
more info
 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
plasmalemma vesicle-associated protein
Names
MECA-32 antigen
plasmalemma vesicle protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032398.2NP_115774.2  plasmalemma vesicle-associated protein

    See identical proteins and their annotated locations for NP_115774.2

    Status: VALIDATED

    Source sequence(s)
    AC127416, AF348403, AI225679, AV003733, BM898788
    Consensus CDS
    CCDS22396.1
    UniProtKB/Swiss-Prot
    Q91VC4
    UniProtKB/TrEMBL
    G3X924
    Related
    ENSMUSP00000035404.5, ENSMUST00000048452.6
    Conserved Domains (1) summary
    pfam06637
    Location:1436
    PV-1; PV-1 protein (PLVAP)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71950397..71964446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242342.3XP_011240644.1  plasmalemma vesicle-associated protein isoform X1

    Conserved Domains (1) summary
    pfam06637
    Location:1405
    PV-1; PV-1 protein (PLVAP)