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PLVAP plasmalemma vesicle associated protein [ Homo sapiens (human) ]

Gene ID: 83483, updated on 23-Nov-2021

Summary

Official Symbol
PLVAPprovided by HGNC
Official Full Name
plasmalemma vesicle associated proteinprovided by HGNC
Primary source
HGNC:HGNC:13635
See related
Ensembl:ENSG00000130300 MIM:607647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PV1; FELS; PV-1; gp68; DIAR10
Expression
Broad expression in thyroid (RPKM 131.8), spleen (RPKM 92.7) and 20 other tissues See more
Orthologs
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Genomic context

See PLVAP in Genome Data Viewer
Location:
19p13.11
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (17351455..17377342, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17462264..17488151, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene DET1 and DDB1 associated 1 Neighboring gene anoctamin 8 Neighboring gene GTP binding protein 3, mitochondrial Neighboring gene uncharacterized LOC105372298 Neighboring gene coiled-coil domain containing 194

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in developmental process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cellular extravasation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cellular extravasation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in protein kinase C signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of vascular permeability IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in caveola IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
plasmalemma vesicle-associated protein
Names
fenestrated endothelial-linked structure protein
fenestrated-endothelial linked structure protein; PV-1 protein
plasmalemma vesicle protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031310.3NP_112600.1  plasmalemma vesicle-associated protein

    See identical proteins and their annotated locations for NP_112600.1

    Status: VALIDATED

    Source sequence(s)
    AC010319, AF326591, AL834363, AW874637, BX380375
    Consensus CDS
    CCDS32952.1
    UniProtKB/Swiss-Prot
    Q9BX97
    Related
    ENSP00000252590.3, ENST00000252590.9
    Conserved Domains (1) summary
    pfam06637
    Location:1440
    PV-1; PV-1 protein (PLVAP)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    17351455..17377342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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