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Usp8 ubiquitin specific peptidase 8 [ Mus musculus (house mouse) ]

Gene ID: 84092, updated on 12-May-2024

Summary

Official Symbol
Usp8provided by MGI
Official Full Name
ubiquitin specific peptidase 8provided by MGI
Primary source
MGI:MGI:1934029
See related
Ensembl:ENSMUSG00000027363 AllianceGenome:MGI:1934029
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ubpy; mKIAA0055
Summary
Enables thiol-dependent deubiquitinase. Involved in endosome organization and protein deubiquitination. Acts upstream of or within Ras protein signal transduction. Located in acrosomal membrane; cytosol; and midbody. Is extrinsic component of endosome membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 45.2), bladder adult (RPKM 14.4) and 25 other tissues See more
Orthologs
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Genomic context

See Usp8 in Genome Data Viewer
Location:
2 F1; 2 61.76 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (126549280..126601234)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (126707201..126759314)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene GA repeat binding protein, beta 1 Neighboring gene zinc finger, BED domain containing 4 pseudogene Neighboring gene RIKEN cDNA A630026N12 gene Neighboring gene STARR-seq mESC enhancer starr_05607 Neighboring gene STARR-seq mESC enhancer starr_05610 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L pseudogene Neighboring gene ubiquitin specific peptidase 50 Neighboring gene transient receptor potential cation channel, subfamily M, member 7 Neighboring gene STARR-positive B cell enhancer ABC_E11158

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables K63-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within Ras protein signal transduction IPI
Inferred from Physical Interaction
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to nerve growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lysosomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K48-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein catabolic process at postsynapse, modulating synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in acrosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 8
Names
deubiquitinating enzyme 8
putative deubiquitinating enzyme
ubiquitin isopeptidase Y
ubiquitin thioesterase 8
ubiquitin thiolesterase 8
ubiquitin-specific-processing protease 8
NP_001239509.1
NP_001409160.1
NP_001409161.1
NP_001409162.1
NP_001409163.1
NP_062703.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252580.2NP_001239509.1  ubiquitin carboxyl-terminal hydrolase 8 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL732330
    Consensus CDS
    CCDS57185.1
    UniProtKB/TrEMBL
    A2AI52, Q3UZ62
    Related
    ENSMUSP00000106046.3, ENSMUST00000110416.3
    Conserved Domains (4) summary
    smart00450
    Location:210321
    RHOD; Rhodanese Homology Domain
    cd02674
    Location:7511080
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:7491079
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam08969
    Location:6126
    USP8_dimer; USP8 dimerization domain
  2. NM_001422231.1NP_001409160.1  ubiquitin carboxyl-terminal hydrolase 8 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL732330
  3. NM_001422232.1NP_001409161.1  ubiquitin carboxyl-terminal hydrolase 8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL732330
  4. NM_001422233.1NP_001409162.1  ubiquitin carboxyl-terminal hydrolase 8 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL732330
  5. NM_001422234.1NP_001409163.1  ubiquitin carboxyl-terminal hydrolase 8 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL732330
  6. NM_019729.4NP_062703.2  ubiquitin carboxyl-terminal hydrolase 8 isoform 2

    See identical proteins and their annotated locations for NP_062703.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL732330
    Consensus CDS
    CCDS16687.1
    UniProtKB/Swiss-Prot
    A2AI53, Q80U87, Q80YP2, Q8R0D3, Q9EQU1, Q9WVP5
    UniProtKB/TrEMBL
    Q3UZ62
    Related
    ENSMUSP00000028841.8, ENSMUST00000028841.14
    Conserved Domains (4) summary
    smart00450
    Location:199310
    RHOD; Rhodanese Homology Domain
    cd02674
    Location:7401069
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:7381068
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam08969
    Location:6115
    USP8_dimer; USP8 dimerization domain

RNA

  1. NR_185498.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL732330

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    126549280..126601234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)