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KBTBD7 kelch repeat and BTB domain containing 7 [ Homo sapiens (human) ]

Gene ID: 84078, updated on 8-Jul-2021

Summary

Official Symbol
KBTBD7provided by HGNC
Official Full Name
kelch repeat and BTB domain containing 7provided by HGNC
Primary source
HGNC:HGNC:25266
See related
Ensembl:ENSG00000120696 MIM:617739
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a transcriptional activator, having been shown to increase the transcription of activator protein-1 and serum response element. The encoded protein can also form a complex with KBTBD6 and CUL3, which regulates the ubiquitylation and degradation of TIAM1, which is a regulator of RAC1. [provided by RefSeq, Jul 2016]
Orthologs
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Genomic context

See KBTBD7 in Genome Data Viewer
Location:
13q14.11
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (41189834..41194569, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (41763970..41768705, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929140 Neighboring gene kelch repeat and BTB domain containing 6 Neighboring gene calmodulin 2 pseudogene 3 Neighboring gene mortality factor 4 like 1 pseudogene 4 Neighboring gene mitochondrial translation release factor 1 Neighboring gene Rac family small GTPase 1 pseudogene 3

Genomic regions, transcripts, and products

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of kelch repeat and BTB (POZ) domain containing 7 (KBTBD7) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434E2318

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kelch repeat and BTB domain-containing protein 7
Names
kelch repeat and BTB (POZ) domain containing 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053142.1 RefSeqGene

    Range
    5016..9751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032138.7NP_115514.2  kelch repeat and BTB domain-containing protein 7

    See identical proteins and their annotated locations for NP_115514.2

    Status: REVIEWED

    Source sequence(s)
    AI631319, AL354696, BC022033, BF436101, BU069965, BU070208, HY094395
    Consensus CDS
    CCDS9377.1
    UniProtKB/Swiss-Prot
    Q8WVZ9
    Related
    ENSP00000368797.3, ENST00000379483.4
    Conserved Domains (4) summary
    PHA03098
    Location:55544
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:384421
    Kelch; KELCH repeat [structural motif]
    cd18273
    Location:37178
    BTB_POZ_KBTBD6_7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7
    cd18482
    Location:168270
    BACK_KBTBD6_7; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    41189834..41194569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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