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MAGT1 magnesium transporter 1 [ Homo sapiens (human) ]

Gene ID: 84061, updated on 22-Sep-2022

Summary

Official Symbol
MAGT1provided by HGNC
Official Full Name
magnesium transporter 1provided by HGNC
Primary source
HGNC:HGNC:28880
See related
Ensembl:ENSG00000102158 MIM:300715; AllianceGenome:HGNC:28880
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IAP; XMEN; MRX95; OST3B; CDG1CC; PRO0756; SLC58A1; bA217H1.1
Summary
This gene encodes a ubiquitously expressed magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause a form of X-linked intellectual disability (XLID). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29. [provided by RefSeq, Jul 2017]
Expression
Ubiquitous expression in thyroid (RPKM 54.7), kidney (RPKM 22.6) and 25 other tissues See more
Orthologs
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Genomic context

See MAGT1 in Genome Data Viewer
Location:
Xq21.1
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (77825747..77895568, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (76263304..76330626, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (77081244..77151065, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 16 Neighboring gene ATRX chromatin remodeler Neighboring gene fatty acid binding protein 5 pseudogene 15 Neighboring gene RNA, U6 small nuclear 854, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 460, pseudogene Neighboring gene cytochrome c oxidase subunit 7B Neighboring gene ATPase copper transporting alpha Neighboring gene C4orf46 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with magnesium transporter 1 (MAGT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14726, MGC64926, DKFZp564K142

Gene Ontology Provided by GOA

General protein information

Preferred Names
magnesium transporter protein 1
Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1
implantation-associated protein
oligosaccharyl transferase subunit MAGT1
oligosaccharyltransferase 3 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016390.1 RefSeqGene

    Range
    5001..74205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_353

mRNA and Protein(s)

  1. NM_001367916.1NP_001354845.1  magnesium transporter protein 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL138743, BC041014, BC060842, DC329979
    UniProtKB/Swiss-Prot
    Q8NBN6
    Related
    ENSP00000480732.1, ENST00000618282.5
    Conserved Domains (1) summary
    pfam04756
    Location:42330
    OST3_OST6; OST3 / OST6 family, transporter family
  2. NM_032121.5NP_115497.4  magnesium transporter protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    BC041014, BC060842, DC329979
    Consensus CDS
    CCDS14436.2
    UniProtKB/Swiss-Prot
    Q9H0U3
    UniProtKB/TrEMBL
    A0A087WU53
    Related
    ENSP00000354649.6, ENST00000358075.11
    Conserved Domains (2) summary
    cd02947
    Location:93203
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    pfam04756
    Location:199348
    OST3_OST6; OST3 / OST6 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    77825747..77895568 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    76263304..76330626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)