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MAGT1 magnesium transporter 1 [ Homo sapiens (human) ]

Gene ID: 84061, updated on 3-Nov-2018

Summary

Official Symbol
MAGT1provided by HGNC
Official Full Name
magnesium transporter 1provided by HGNC
Primary source
HGNC:HGNC:28880
See related
Ensembl:ENSG00000102158 MIM:300715; Vega:OTTHUMG00000021882
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IAP; XMEN; MRX95; OST3B; PRO0756; bA217H1.1
Summary
This gene encodes a ubiquitously expressed magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause a form of X-linked intellectual disability (XLID). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29. [provided by RefSeq, Jul 2017]
Expression
Ubiquitous expression in thyroid (RPKM 54.7), kidney (RPKM 22.6) and 25 other tissues See more
Orthologs

Genomic context

See MAGT1 in Genome Data Viewer
Location:
Xq21.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (77826364..77895568, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (77081861..77151090, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 16 Neighboring gene ATRX, chromatin remodeler Neighboring gene fatty acid binding protein 5 pseudogene 15 Neighboring gene RNA, U6 small nuclear 854, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 460, pseudogene Neighboring gene cytochrome c oxidase subunit 7B Neighboring gene chromosome 4 open reading frame 46 pseudogene Neighboring gene ATPase copper transporting alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with magnesium transporter 1 (MAGT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14726, MGC64926, DKFZp564K142

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
magnesium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
magnesium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
protein N-linked glycosylation NAS
Non-traceable Author Statement
more info
PubMed 
protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein N-linked glycosylation via asparagine IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
azurophil granule membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
membrane HDA PubMed 
oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oligosaccharyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
magnesium transporter protein 1
Names
implantation-associated protein
oligosaccharyltransferase 3 homolog B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016390.1 RefSeqGene

    Range
    5001..74205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_353

mRNA and Protein(s)

  1. NM_032121.5NP_115497.4  magnesium transporter protein 1

    Status: REVIEWED

    Source sequence(s)
    BC041014, BC060842, DC329979
    Consensus CDS
    CCDS14436.2
    UniProtKB/Swiss-Prot
    Q9H0U3
    UniProtKB/TrEMBL
    A0A087WU53
    Related
    ENSP00000478379.1, ENST00000610432.4
    Conserved Domains (2) summary
    cd02947
    Location:93203
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    pfam04756
    Location:199348
    OST3_OST6; OST3 / OST6 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    77826364..77895568 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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