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FCAMR Fc alpha and mu receptor [ Homo sapiens (human) ]

Gene ID: 83953, updated on 22-Sep-2022

Summary

Official Symbol
FCAMRprovided by HGNC
Official Full Name
Fc alpha and mu receptorprovided by HGNC
Primary source
HGNC:HGNC:24692
See related
Ensembl:ENSG00000162897 MIM:605484; AllianceGenome:HGNC:24692
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD351; FCA/MR; FKSG87; Fcalpha/muR
Summary
Predicted to enable IgA binding activity; IgM binding activity; and transmembrane signaling receptor activity. Predicted to be involved in adaptive immune response. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney (RPKM 16.8), lymph node (RPKM 10.8) and 4 other tissues See more
Orthologs
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Genomic context

See FCAMR in Genome Data Viewer
Location:
1q32.1
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206957967..206970638, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (206223168..206235661, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207131312..207143805, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene negCOR silencer S10 Neighboring gene Fc mu receptor Neighboring gene polymeric immunoglobulin receptor Neighboring gene tRNA-Pro (anticodon TGG) 5-1 Neighboring gene chromosome 1 open reading frame 116

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Preincubation of monocytes with HIV-1 gp120 depresses anti-CD3 antibody-induced T cell stimulation and Fc receptor-mediated phagocytosis PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor
Names
Fc alpha/mu receptor
Fc fragment of IgA and IgM receptor
Fc receptor, IgA, IgM, high affinity
immunity related factor
receptor for Fc fragment of IgA and IgM

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122979.3NP_001116451.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform a

    See identical proteins and their annotated locations for NP_001116451.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 3. The resulting isoform (a) has a shorter and distinct C-terminus, compared to isoform b. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC098935, AI269147, BC109263, BX090153, CD633520
    Consensus CDS
    CCDS41460.1
    UniProtKB/Swiss-Prot
    Q8WWV6
    Related
    ENSP00000392707.2, ENST00000450945.3
    Conserved Domains (2) summary
    cd05716
    Location:114214
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:112215
    IG_like; Immunoglobulin like
  2. NM_001170631.2NP_001164102.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform b

    See identical proteins and their annotated locations for NP_001164102.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (b).
    Source sequence(s)
    AI269147, AK298394
    Consensus CDS
    CCDS53468.1
    UniProtKB/TrEMBL
    A0A0B4J1S2
    Related
    ENSP00000316491.4, ENST00000324852.9
    Conserved Domains (2) summary
    cd05716
    Location:114214
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:112215
    IG_like; Immunoglobulin like
  3. NM_032029.5NP_114418.2  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform a

    See identical proteins and their annotated locations for NP_114418.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 3. The resulting isoform (a) has a shorter and distinct C-terminus, compared to isoform b. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC098935, AI269147, BC109263, BX090153, DC361666
    Consensus CDS
    CCDS41460.1
    UniProtKB/Swiss-Prot
    Q8WWV6
    Related
    ENSP00000383746.3, ENST00000400962.8
    Conserved Domains (2) summary
    cd05716
    Location:114214
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:112215
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    206957967..206970638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431769.1XP_047287725.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X1

    UniProtKB/TrEMBL
    A0A0B4J1S2
  2. XM_011510051.3XP_011508353.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X1

    See identical proteins and their annotated locations for XP_011508353.1

    UniProtKB/TrEMBL
    A0A0B4J1S2
    Conserved Domains (2) summary
    cd05716
    Location:114214
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:112215
    IG_like; Immunoglobulin like
  3. XM_047431771.1XP_047287727.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X3

  4. XM_011510052.3XP_011508354.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X2

    Conserved Domains (2) summary
    cd05716
    Location:102202
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:100203
    IG_like; Immunoglobulin like

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    206223168..206235661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001122980.1: Suppressed sequence

    Description
    NM_001122980.1: This RefSeq was permanently suppressed because it represents a transcript produced via non-consensus splicing and there is limited support for that atypical event.