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PIP5K1A phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [ Homo sapiens (human) ]

Gene ID: 8394, updated on 2-Nov-2024

Summary

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Official Symbol
PIP5K1Aprovided by HGNC
Official Full Name
phosphatidylinositol-4-phosphate 5-kinase type 1 alphaprovided by HGNC
Primary source
HGNC:HGNC:8994
See related
Ensembl:ENSG00000143398 MIM:603275; AllianceGenome:HGNC:8994
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and kinase binding activity. Involved in several processes, including activation of GTPase activity; focal adhesion assembly; and ruffle assembly. Located in several cellular components, including lamellipodium; nucleus; and ruffle membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 22.2), placenta (RPKM 13.0) and 25 other tissues See more
Orthologs
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Genomic context

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See PIP5K1A in Genome Data Viewer
Location:
1q21.3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (151195419..151249531)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (150319124..150373243)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151171028..151222007)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TNFAIP8L2-SCNM1 readthrough Neighboring gene sodium channel modifier 1 Neighboring gene tropomodulin 4 Neighboring gene vacuolar protein sorting 72 homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1711 Neighboring gene uncharacterized LOC124904419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1713 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:151183035-151183192 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151183741-151184733 Neighboring gene MPRA-validated peak410 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1316 Neighboring gene Sharpr-MPRA regulatory region 10214 Neighboring gene proteasome 26S subunit ubiquitin receptor, non-ATPase 4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151253738-151254622 Neighboring gene ZNF687 antisense RNA 1 Neighboring gene zinc finger protein 687

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Assignment of type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) to human chromosome bands 1q22--> q24 by in situ hybridization. Xie Y, et al. Cytogenet Cell Genet, 2000. PMID 10828584
  2. Study of arachidonoyl specificity in two enzymes of the PI cycle. Shulga YV, et al. J Mol Biol, 2011 Jun 3. PMID 21477596, Free PMC Article
  3. The role of PIP5K1α/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1α inhibitor. Sarwar M, et al. Oncogene, 2019 Jan. PMID 30104711, Free PMC Article
  4. Increasing plasma membrane phosphatidylinositol(4,5)bisphosphate biosynthesis increases phosphoinositide metabolism in Nicotiana tabacum. Im YJ, et al. Plant Cell, 2007 May. PMID 17496116, Free PMC Article
  5. Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase Ialpha are required for invadopodia formation in human breast cancer cells. Yamaguchi H, et al. Cancer Sci, 2010 Jul. PMID 20426790, Free PMC Article

See all (108) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lipid kinase PIP5K1A regulates let-7 microRNA biogenesis through interacting with nuclear export protein XPO5.
    Title: Lipid kinase PIP5K1A regulates let-7 microRNA biogenesis through interacting with nuclear export protein XPO5.
  2. Human IL-17A protein production is controlled through a PIP5K1alpha-dependent translational checkpoint.
    Title: Human IL-17A protein production is controlled through a PIP5K1α-dependent translational checkpoint.
  3. FcgammaRIIIa receptor interacts with androgen receptor and PIP5K1alpha to promote growth and metastasis of prostate cancer.
    Title: FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer.
  4. Circ_PIP5K1A regulates cisplatin resistance and malignant progression in non-small cell lung cancer cells and xenograft murine model via depending on miR-493-5p/ROCK1 axis.
    Title: Circ_PIP5K1A regulates cisplatin resistance and malignant progression in non-small cell lung cancer cells and xenograft murine model via depending on miR-493-5p/ROCK1 axis.
  5. CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis.
    Title: CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis.
  6. Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells.
    Title: Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells.
  7. Phosphatidylinositol-4-phosphate 5-kinase type 1alpha attenuates Abeta production by promoting non-amyloidogenic processing of amyloid precursor protein.
    Title: Phosphatidylinositol-4-phosphate 5-kinase type 1α attenuates Aβ production by promoting non-amyloidogenic processing of amyloid precursor protein.
  8. Type I Phosphatidylinositol-4-Phosphate 5-Kinases alpha and gamma Play a Key Role in Targeting HIV-1 Pr55(Gag) to the Plasma Membrane.
    Title: Type I Phosphatidylinositol-4-Phosphate 5-Kinases α and γ Play a Key Role in Targeting HIV-1 Pr55(Gag) to the Plasma Membrane.
  9. The results suggest that PIP5KA is a novel degradative substrate of NEDD4 and that the PIP5KA-dependent phosphatidylinositol 4,5-diphosphate pool contributing to breast cancer cell proliferation through PI3K/Akt activation is negatively controlled by NEDD4.
    Title: NEDD4-induced degradative ubiquitination of phosphatidylinositol 4-phosphate 5-kinase α and its implication in breast cancer cell proliferation.
  10. PIP5K1alpha was associated with poor patient outcome in triple-negative BC. It increased expression of pSer-473 AKT and invasiveness of triple-negative MDA-MB-231 cells. Inhibition reduced expression of pSer-473 AKT and its downstream effectors in xenograft tumors. In ER(+) cancer cells, PIP5K1alpha acted on pSer-473 AKT, and was in complexes with VEGFR2, serving as co-factor of ER-alpha to regulate activities of targe...
    Title: The role of PIP5K1α/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1α inhibitor.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 Env-gp120 protein induces PIP(2) production in permissive lymphocytes through the activation of phosphatidylinositol-4-phosphate 5-kinase (PI4P5-K) Ialpha. Cells overexpressing mutant D227A (D/A)-PI4P5-K Ialpha severely reduce HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity TAS
Traceable Author Statement
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables 1-phosphatidylinositol-5-kinase activity TAS
Traceable Author Statement
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol kinase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in activation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in fibroblast migration IEA
Inferred from Electronic Annotation
more info
  
involved_in focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycerophospholipid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in keratinocyte differentiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in phagocytosis TAS
Traceable Author Statement
more info
 PubMed 
involved_in phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction TAS
Traceable Author Statement
more info
  
involved_in ruffle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in focal adhesion HDA PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mRNA cleavage and polyadenylation specificity factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ruffle membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
Names
68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha
PIP5K1-alpha
PIP5KIalpha
phosphatidylinositol 4-phosphate 5-kinase type I alpha
ptdIns(4)P-5-kinase 1 alpha
NP_001129108.1
NP_001129109.1
NP_001129110.1
NP_001317618.1
NP_003548.1
XP_005245582.1
XP_005245584.1
XP_005245585.1
XP_005245587.1
XP_005245589.1
XP_006711626.1
XP_006711627.1
XP_006711630.1
XP_006711631.2
XP_011508345.1
XP_011508347.1
XP_011508348.1
XP_011508351.1
XP_016857928.1
XP_016857929.1
XP_024305897.1
XP_024305898.1
XP_024305899.1
XP_047287591.1
XP_047287594.1
XP_047287607.1
XP_047287613.1
XP_047287614.1
XP_047287626.1
XP_047287629.1
XP_047287631.1
XP_047287633.1
XP_047287635.1
XP_047287637.1
XP_047287638.1
XP_047287643.1
XP_047287650.1
XP_047287654.1
XP_047287657.1
XP_047287658.1
XP_047287659.1
XP_047287660.1
XP_047287662.1
XP_047287665.1
XP_047287666.1
XP_047287668.1
XP_047287676.1
XP_047287682.1
XP_047287685.1
XP_047287686.1
XP_047287688.1
XP_054194987.1
XP_054194988.1
XP_054194989.1
XP_054194990.1
XP_054194991.1
XP_054194992.1
XP_054194993.1
XP_054194994.1
XP_054194995.1
XP_054194996.1
XP_054194997.1
XP_054194998.1
XP_054194999.1
XP_054195000.1
XP_054195001.1
XP_054195002.1
XP_054195003.1
XP_054195004.1
XP_054195005.1
XP_054195006.1
XP_054195007.1
XP_054195008.1
XP_054195009.1
XP_054195010.1
XP_054195011.1
XP_054195012.1
XP_054195013.1
XP_054195014.1
XP_054195015.1
XP_054195016.1
XP_054195017.1
XP_054195018.1
XP_054195019.1
XP_054195020.1
XP_054195021.1
XP_054195022.1
XP_054195023.1
XP_054195024.1
XP_054195025.1
XP_054195026.1
XP_054195027.1
XP_054195028.1
XP_054195029.1
XP_054195030.1
XP_054195031.1
XP_054195032.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135636.2 → NP_001129108.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two in-frame coding exons, as compared to variant 1. The resulting isoform (3) is shorter but has identical N- and C-termini, as compared to isoform 1.
    Source sequence(s)
    AL592424
    Consensus CDS
    CCDS44220.1
    UniProtKB/Swiss-Prot
    Q99755
    Related
    ENSP00000415648.2, ENST00000441902.6
    Conserved Domains (1) summary
    smart00330
    Location:97 → 409
    PIPKc; Phosphatidylinositol phosphate kinases

  2. NM_001135637.2 → NP_001129109.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 4

    See identical proteins and their annotated locations for NP_001129109.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks 3 nt at an alternate splice site and two in-frame exons in the CDS, as compared to variant 1. The resulting isoform (4) is shorter but has identical N- and C-termini, as compared to isoform 1.
    Source sequence(s)
    AL592424
    Consensus CDS
    CCDS44221.1
    UniProtKB/TrEMBL
    B2R729
    Related
    ENSP00000357885.4, ENST00000368890.8
    Conserved Domains (1) summary
    smart00330
    Location:96 → 436
    PIPKc; Phosphatidylinositol phosphate kinases

  3. NM_001135638.2 → NP_001129110.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 1

    See identical proteins and their annotated locations for NP_001129110.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL592424
    Consensus CDS
    CCDS44219.1
    UniProtKB/Swiss-Prot
    A8K4Q0, B4DIN0, Q99754, Q99755, Q99756
    Related
    ENSP00000357883.4, ENST00000368888.9
    Conserved Domains (1) summary
    smart00330
    Location:109 → 449
    PIPKc; Phosphatidylinositol phosphate kinases

  4. NM_001330689.2 → NP_001317618.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL592424
    Consensus CDS
    CCDS81374.1
    UniProtKB/TrEMBL
    A6PW57
    Related
    ENSP00000386432.1, ENST00000409426.5

  5. NM_003557.3 → NP_003548.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 2

    See identical proteins and their annotated locations for NP_003548.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks 3 nt at an alternate splice site and an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (2) is shorter but has identical N- and C-termini, as compared to isoform 1.
    Source sequence(s)
    AL592424
    Consensus CDS
    CCDS990.1
    UniProtKB/Swiss-Prot
    Q99755
    Related
    ENSP00000271663.7, ENST00000349792.9
    Conserved Domains (1) summary
    smart00330
    Location:96 → 436
    PIPKc; Phosphatidylinositol phosphate kinases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    151195419..151249531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431638.1 → XP_047287594.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X4

  2. XM_024450129.2 → XP_024305897.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X5

    Conserved Domains (1) summary
    smart00330
    Location:113 → 453
    PIPKc; Phosphatidylinositol phosphate kinases

  3. XM_006711568.5 → XP_006711631.2  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X4

    Conserved Domains (1) summary
    smart00330
    Location:114 → 454
    PIPKc; Phosphatidylinositol phosphate kinases

  4. XM_011510043.4 → XP_011508345.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X10

    Conserved Domains (1) summary
    smart00330
    Location:102 → 442
    PIPKc; Phosphatidylinositol phosphate kinases

  5. XM_024450130.2 → XP_024305898.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X11

    Conserved Domains (1) summary
    smart00330
    Location:101 → 441
    PIPKc; Phosphatidylinositol phosphate kinases

  6. XM_047431658.1 → XP_047287614.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X10

  7. XM_047431657.1 → XP_047287613.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X10

  8. XM_047431670.1 → XP_047287626.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X11

  9. XM_047431681.1 → XP_047287637.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X20

  10. XM_005245530.6 → XP_005245587.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X12

    Conserved Domains (1) summary
    smart00330
    Location:101 → 441
    PIPKc; Phosphatidylinositol phosphate kinases

  11. XM_047431709.1 → XP_047287665.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X29

  12. XM_005245532.5 → XP_005245589.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X15

    Conserved Domains (1) summary
    smart00330
    Location:89 → 429
    PIPKc; Phosphatidylinositol phosphate kinases

  13. XM_047431712.1 → XP_047287668.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X33

  14. XM_047431701.1 → XP_047287657.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X24

  15. XM_011510045.4 → XP_011508347.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X13

    Conserved Domains (1) summary
    smart00330
    Location:100 → 440
    PIPKc; Phosphatidylinositol phosphate kinases

  16. XM_047431710.1 → XP_047287666.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X30

  17. XM_011510046.4 → XP_011508348.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X16

    Conserved Domains (1) summary
    smart00330
    Location:88 → 428
    PIPKc; Phosphatidylinositol phosphate kinases

  18. XM_047431720.1 → XP_047287676.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X34

  19. XM_047431702.1 → XP_047287658.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X25

  20. XM_047431732.1 → XP_047287688.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X38

  21. XM_006711567.5 → XP_006711630.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X21

    See identical proteins and their annotated locations for XP_006711630.1

    Conserved Domains (1) summary
    smart00330
    Location:73 → 413
    PIPKc; Phosphatidylinositol phosphate kinases

  22. XM_047431698.1 → XP_047287654.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X23

  23. XM_011510049.4 → XP_011508351.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X21

    See identical proteins and their annotated locations for XP_011508351.1

    Conserved Domains (1) summary
    smart00330
    Location:73 → 413
    PIPKc; Phosphatidylinositol phosphate kinases

  24. XM_047431694.1 → XP_047287650.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X23

  25. XM_006711563.5 → XP_006711626.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1

    Conserved Domains (1) summary
    smart00330
    Location:121 → 461
    PIPKc; Phosphatidylinositol phosphate kinases

  26. XM_047431673.1 → XP_047287629.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X14

  27. XM_006711564.5 → XP_006711627.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X6

    Conserved Domains (1) summary
    smart00330
    Location:109 → 449
    PIPKc; Phosphatidylinositol phosphate kinases

  28. XM_047431704.1 → XP_047287660.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X27

  29. XM_047431677.1 → XP_047287633.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X18

  30. XM_005245525.6 → XP_005245582.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2

    Conserved Domains (1) summary
    smart00330
    Location:119 → 459
    PIPKc; Phosphatidylinositol phosphate kinases

  31. XM_005245528.6 → XP_005245585.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X8

    Conserved Domains (1) summary
    smart00330
    Location:107 → 447
    PIPKc; Phosphatidylinositol phosphate kinases

  32. XM_047431635.1 → XP_047287591.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3

  33. XM_047431651.1 → XP_047287607.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X9

  34. XM_047431703.1 → XP_047287659.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X26

  35. XM_047431675.1 → XP_047287631.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X17

  36. XM_017002439.2 → XP_016857928.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X31

  37. XM_047431729.1 → XP_047287685.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X36

  38. XM_005245527.5 → XP_005245584.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X7

    Conserved Domains (1) summary
    smart00330
    Location:108 → 448
    PIPKc; Phosphatidylinositol phosphate kinases

  39. XM_047431706.1 → XP_047287662.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X28

  40. XM_047431679.1 → XP_047287635.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X19

  41. XM_047431726.1 → XP_047287682.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X35

  42. XM_017002440.2 → XP_016857929.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X32

  43. XM_047431687.1 → XP_047287643.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X22

  44. XM_047431730.1 → XP_047287686.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X37

  45. XM_047431682.1 → XP_047287638.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X21

  46. XM_024450131.2 → XP_024305899.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X23

    UniProtKB/TrEMBL
    B2R729
    Conserved Domains (1) summary
    smart00330
    Location:61 → 401
    PIPKc; Phosphatidylinositol phosphate kinases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    150319124..150373243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339025.1 → XP_054195000.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X11

  2. XM_054339022.1 → XP_054194997.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X10

  3. XM_054339016.1 → XP_054194991.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X5

  4. XM_054339023.1 → XP_054194998.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X10

  5. XM_054339021.1 → XP_054194996.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X10

  6. XM_054339027.1 → XP_054195002.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X11

  7. XM_054339026.1 → XP_054195001.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X11

  8. XM_054339035.1 → XP_054195010.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X20

  9. XM_054339015.1 → XP_054194990.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X4

  10. XM_054339024.1 → XP_054194999.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X12

  11. XM_054339048.1 → XP_054195023.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X29

  12. XM_054339030.1 → XP_054195005.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X15

  13. XM_054339052.1 → XP_054195027.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X33

  14. XM_054339043.1 → XP_054195018.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X24

  15. XM_054339028.1 → XP_054195003.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X13

  16. XM_054339049.1 → XP_054195024.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X30

  17. XM_054339031.1 → XP_054195006.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X16

  18. XM_054339053.1 → XP_054195028.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X34

  19. XM_054339044.1 → XP_054195019.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X25

  20. XM_054339057.1 → XP_054195032.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X38

  21. XM_054339038.1 → XP_054195013.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X21

  22. XM_054339042.1 → XP_054195017.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X23

  23. XM_054339037.1 → XP_054195012.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X21

  24. XM_054339041.1 → XP_054195016.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X23

  25. XM_054339012.1 → XP_054194987.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1

  26. XM_054339029.1 → XP_054195004.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X14

  27. XM_054339017.1 → XP_054194992.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X6

  28. XM_054339046.1 → XP_054195021.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X27

  29. XM_054339033.1 → XP_054195008.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X18

  30. XM_054339013.1 → XP_054194988.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2

  31. XM_054339019.1 → XP_054194994.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X8

  32. XM_054339014.1 → XP_054194989.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3

  33. XM_054339020.1 → XP_054194995.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X9

  34. XM_054339045.1 → XP_054195020.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X26

  35. XM_054339032.1 → XP_054195007.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X17

  36. XM_054339050.1 → XP_054195025.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X31

  37. XM_054339055.1 → XP_054195030.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X36

  38. XM_054339018.1 → XP_054194993.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X7

  39. XM_054339047.1 → XP_054195022.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X28

  40. XM_054339034.1 → XP_054195009.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X19

  41. XM_054339054.1 → XP_054195029.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X35

  42. XM_054339051.1 → XP_054195026.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X32

  43. XM_054339039.1 → XP_054195014.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X22

  44. XM_054339056.1 → XP_054195031.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X37

  45. XM_054339036.1 → XP_054195011.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X21

  46. XM_054339040.1 → XP_054195015.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X23

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99755.1 GenPept UniProtKB/Swiss-Prot:Q99755

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