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HAC12 histone acetyltransferase of the CBP family 12 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 838242, updated on 18-Sep-2024

Summary

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Official Symbol
HAC12
Official Full Name
histone acetyltransferase of the CBP family 12
Primary source
TAIR:AT1G16710
Locus tag
AT1G16710
See related
Araport:AT1G16710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F19K19.17; histone acetyltransferase of the CBP family 12
Summary
Encodes an enzyme with histone acetyltransferase activity that can use both H3 and H4 histones as substrates. No single prior lysine acetylation is sufficient to block HAC12 acetylation of the H3 or H4 peptides, suggesting that HAC12 can acetylate any of several lysines present in the peptides.
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Genomic context

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Location:
chromosome: 1
Exon count:
18
Sequence:
Chromosome: 1; NC_003070.9 (5713794..5722614)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Enhancer of polycomb-like transcription factor protein Neighboring gene Alpha-helical ferredoxin Neighboring gene p300/CBP acetyltransferase-related protein-like protein Neighboring gene ncRNA Neighboring gene high chlorophyll fluorescence phenotype 173 Neighboring gene ncRNA Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of plant CBP/p300-like genes in the regulation of flowering time. Han SK, et al. Plant J, 2007 Jan. PMID 17144897
  2. In vitro specificities of Arabidopsis co-activator histone acetyltransferases: implications for histone hyperacetylation in gene activation. Earley KW, et al. Plant J, 2007 Nov. PMID 17877703
  3. Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes. Pandey R, et al. Nucleic Acids Res, 2002 Dec 1. PMID 12466527, Free PMC Article
  4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

General gene information

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Homology

NM_101532.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within flower development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within protein acetylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
histone acetyltransferase of the CBP family 12
NP_001185015.1
  • histone acetyltransferase of the CBP family 12 (HAC12); FUNCTIONS IN: histone acetyltransferase activity, transcription cofactor activity; INVOLVED IN: flower development, regulation of transcription, DNA-dependent, protein amino acid acetylation; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Histone H3-K56 acetyltransferase, RTT109 (InterPro:IPR013178), Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, TAZ-type (InterPro:IPR000197), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, ZZ-type (InterPro:IPR000433); BEST Arabidopsis thaliana protein match is: histone acetyltransferase of the CBP family 1 (TAIR:AT1G79000.1).
NP_173115.1
  • histone acetyltransferase of the CBP family 12 (HAC12); FUNCTIONS IN: histone acetyltransferase activity, transcription cofactor activity; INVOLVED IN: flower development, regulation of transcription, DNA-dependent, protein amino acid acetylation; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Histone H3-K56 acetyltransferase, RTT109 (InterPro:IPR013178), Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, TAZ-type (InterPro:IPR000197), Zinc finger, PHD-type (InterPro:IPR001965), Zinc finger, ZZ-type (InterPro:IPR000433); BEST Arabidopsis thaliana protein match is: histone acetyltransferase of the CBP family 1 (TAIR:AT1G79000.1); Has 5603 Blast hits to 4159 proteins in 302 species: Archae - 0; Bacteria - 235; Metazoa - 1739; Fungi - 482; Plants - 447; Viruses - 18; Other Eukaryotes - 2682 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    5713794..5722614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001332246.1 → NP_001321737.1  histone acetyltransferase of the CBP family 12 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ARV8, A0A5S9UR80, A0A654EAH3

  2. NM_001332247.1 → NP_001321739.1  histone acetyltransferase of the CBP family 12 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ARV7, A0A5S9UR80, A0A654EAH3

  3. NM_001332248.1 → NP_001321738.1  histone acetyltransferase of the CBP family 12 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ARV7, A0A5S9UR80, A0A654EAH3

  4. NM_001332249.1 → NP_001321742.1  histone acetyltransferase of the CBP family 12 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ARV7, A0A5S9UR80, A0A654EAH3

  5. NM_001332250.1 → NP_001321741.1  histone acetyltransferase of the CBP family 12 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ARV8, A0A5S9UR80, A0A654EAH3

  6. NM_001332251.1 → NP_001321736.1  histone acetyltransferase of the CBP family 12 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ARV8, A0A5S9UR80, A0A654EAH3

  7. NM_001332252.1 → NP_001321735.1  histone acetyltransferase of the CBP family 12 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ARU4, A0A5S9UR80, A0A654EAH3

  8. NM_001332245.1 → NP_001321740.1  histone acetyltransferase of the CBP family 12 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ARV8, A0A5S9UR80, A0A654EAH3

  9. NM_001198086.1 → NP_001185015.1  histone acetyltransferase of the CBP family 12 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001185015.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9UR80, A0A654EAH3, F4I4I8
    Conserved Domains (4) summary
    smart00551
    Location:609 → 687
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd15614
    Location:971 → 1043
    PHD_HAC_like; PHD finger found in Arabidopsis thaliana histone acetyltransferases (HATs) HAC and similar proteins
    cl00295
    Location:1502 → 1547
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
    cl02120
    Location:1117 → 1315
    HAT_KAT11; Histone acetylation protein

  10. NM_101532.3 → NP_173115.1  histone acetyltransferase of the CBP family 12 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_173115.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FWQ5
    UniProtKB/TrEMBL
    A0A5S9UR80, A0A654EAH3
    Conserved Domains (4) summary
    smart00551
    Location:638 → 716
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd15614
    Location:1000 → 1072
    PHD_HAC_like; PHD finger found in Arabidopsis thaliana histone acetyltransferases (HATs) HAC and similar proteins
    cl00295
    Location:1531 → 1576
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
    cl02120
    Location:1146 → 1344
    HAT_KAT11; Histone acetylation protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FWQ5.2

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