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Tnk1 tyrosine kinase, non-receptor, 1 [ Mus musculus (house mouse) ]

Gene ID: 83813, updated on 8-Feb-2024

Summary

Official Symbol
Tnk1provided by MGI
Official Full Name
tyrosine kinase, non-receptor, 1provided by MGI
Primary source
MGI:MGI:1930958
See related
Ensembl:ENSMUSG00000001583 AllianceGenome:MGI:1930958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kos1; Tnk1a; Tnk1b
Summary
Enables ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in negative regulation of Ras protein signal transduction; negative regulation of cell growth; and protein autophosphorylation. Located in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; pituitary gland; respiratory system; and thymus. Orthologous to human TNK1 (tyrosine kinase non receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 21.8), large intestine adult (RPKM 15.1) and 28 other tissues See more
Orthologs
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Genomic context

See Tnk1 in Genome Data Viewer
Location:
11 B3; 11 42.9 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69741389..69749556, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69850563..69858730, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene neuroligin 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69651958-69652141 Neighboring gene transmembrane protein 256 Neighboring gene phospholipid scramblase 3 Neighboring gene predicted gene, 32708 Neighboring gene STARR-seq mESC enhancer starr_29868 Neighboring gene transmembrane protein 95

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
non-receptor tyrosine-protein kinase TNK1
Names
kinase of embryonic stem cells
non-receptor tyrosine kinase
NP_114086.3
XP_006534617.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031880.3NP_114086.3  non-receptor tyrosine-protein kinase TNK1

    See identical proteins and their annotated locations for NP_114086.3

    Status: VALIDATED

    Source sequence(s)
    AK033440, AK167292, BB676903, BX528991
    Consensus CDS
    CCDS24917.1
    UniProtKB/Swiss-Prot
    Q8CCC4, Q8K0X9, Q91V11, Q99ML2
    UniProtKB/TrEMBL
    Q5F2B4
    Related
    ENSMUSP00000001626.4, ENSMUST00000001626.10
    Conserved Domains (4) summary
    cd09539
    Location:1667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cl17036
    Location:395436
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:120380
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:624663
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69741389..69749556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534554.3XP_006534617.1  non-receptor tyrosine-protein kinase TNK1 isoform X1

    See identical proteins and their annotated locations for XP_006534617.1

    UniProtKB/Swiss-Prot
    Q8CCC4, Q8K0X9, Q91V11, Q99ML2
    UniProtKB/TrEMBL
    Q5F2B4
    Related
    ENSMUSP00000104268.2, ENSMUST00000108628.8
    Conserved Domains (4) summary
    cd09539
    Location:1667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cl17036
    Location:395436
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:120380
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:624663
    UBA_like_SF; UBA domain-like superfamily

RNA

  1. XR_879778.2 RNA Sequence