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TNK1 tyrosine kinase non receptor 1 [ Homo sapiens (human) ]

Gene ID: 8711, updated on 17-Jun-2019

Summary

Official Symbol
TNK1provided by HGNC
Official Full Name
tyrosine kinase non receptor 1provided by HGNC
Primary source
HGNC:HGNC:11940
See related
Ensembl:ENSG00000174292 MIM:608076
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in stomach (RPKM 6.3), duodenum (RPKM 4.1) and 23 other tissues See more
Orthologs

Genomic context

See TNK1 in Genome Data Viewer
Location:
17p13.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7380559..7389964)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7284293..7293093)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 Neighboring gene potassium channel tetramerization domain containing 11 Neighboring gene transmembrane protein 95 Neighboring gene TMEM256-PLSCR3 readthrough (NMD candidate) Neighboring gene phospholipid scramblase 3 Neighboring gene transmembrane protein 256 Neighboring gene neuroligin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of tyrosine kinase, non-receptor, 1 (TNK1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC46193

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
non-receptor tyrosine-protein kinase TNK1
Names
CD38 negative kinase 1
NP_001238831.1
NP_003976.2
XP_011522347.1
XP_011522348.1
XP_011522349.1
XP_011522350.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001251902.2NP_001238831.1  non-receptor tyrosine-protein kinase TNK1 isoform 1

    See identical proteins and their annotated locations for NP_001238831.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC113189
    Consensus CDS
    CCDS58510.1
    UniProtKB/Swiss-Prot
    Q13470
    Related
    ENSP00000459799.1, ENST00000576812.5
    Conserved Domains (6) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:119377
    STYKc; Protein kinase; unclassified specificity
    smart00326
    Location:385441
    SH3; Src homology 3 domains
    cd14328
    Location:624663
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cl21453
    Location:120379
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:594637
    UBA_like_SF; UBA domain-like superfamily
  2. NM_003985.5NP_003976.2  non-receptor tyrosine-protein kinase TNK1 isoform 2

    See identical proteins and their annotated locations for NP_003976.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in a shorter isoform (2) missing a 5 aa protein segment compared to isoform 1.
    Source sequence(s)
    AC113189
    Consensus CDS
    CCDS45602.1
    UniProtKB/Swiss-Prot
    Q13470
    Related
    ENSP00000458834.1, ENST00000570896.5
    Conserved Domains (6) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:119377
    STYKc; Protein kinase; unclassified specificity
    cd14328
    Location:619658
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cl17036
    Location:396435
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:120379
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:589632
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7380559..7389964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524045.2XP_011522347.1  non-receptor tyrosine-protein kinase TNK1 isoform X1

    See identical proteins and their annotated locations for XP_011522347.1

    UniProtKB/Swiss-Prot
    Q13470
    Conserved Domains (6) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:119377
    STYKc; Protein kinase; unclassified specificity
    cd14328
    Location:619658
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cl17036
    Location:396435
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:120379
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:589632
    UBA_like_SF; UBA domain-like superfamily
  2. XM_011524047.3XP_011522349.1  non-receptor tyrosine-protein kinase TNK1 isoform X3

    Conserved Domains (4) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:119377
    STYKc; Protein kinase; unclassified specificity
    cl17036
    Location:396435
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:120379
    PKc_like; Protein Kinases, catalytic domain
  3. XM_011524046.3XP_011522348.1  non-receptor tyrosine-protein kinase TNK1 isoform X2

    Conserved Domains (6) summary
    cd09539
    Location:667
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:119377
    STYKc; Protein kinase; unclassified specificity
    cd14328
    Location:617656
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cl17036
    Location:396435
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:120379
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:587630
    UBA_like_SF; UBA domain-like superfamily
  4. XM_011524048.1XP_011522350.1  non-receptor tyrosine-protein kinase TNK1 isoform X4

    Conserved Domains (4) summary
    cd14328
    Location:462501
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cl17036
    Location:239278
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:7222
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:432475
    UBA_like_SF; UBA domain-like superfamily

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_016107299.1 Reference GRCh38.p13 PATCHES

    Range
    1546..10223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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