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KCNK16 potassium two pore domain channel subfamily K member 16 [ Homo sapiens (human) ]

Gene ID: 83795, updated on 22-Sep-2022

Summary

Official Symbol
KCNK16provided by HGNC
Official Full Name
potassium two pore domain channel subfamily K member 16provided by HGNC
Primary source
HGNC:HGNC:14464
See related
Ensembl:ENSG00000095981 MIM:607369; AllianceGenome:HGNC:14464
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TALK1; TALK-1; K2p16.1
Summary
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
Expression
Biased expression in stomach (RPKM 3.5), pancreas (RPKM 1.4) and 2 other tissues See more
Orthologs
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Genomic context

See KCNK16 in Genome Data Viewer
Location:
6p21.2
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (39314570..39322968, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (39139241..39147515, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (39282474..39290744, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4644 Neighboring gene potassium two pore domain channel subfamily K member 5 Neighboring gene uncharacterized LOC105375047 Neighboring gene potassium two pore domain channel subfamily K member 17 Neighboring gene uncharacterized LOC107986594 Neighboring gene ankyrin repeat domain 39 pseudogene Neighboring gene kinesin family member 6 Neighboring gene E2F transcription factor 4 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
potassium channel subfamily K member 16
Names
2P domain potassium channel Talk-1
TWIK-related alkaline pH-activated K(+) channel 1
pancreatic potassium channel Talk-1
potassium channel, subfamily K, member 16
potassium channel, two pore domain subfamily K, member 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135105.2NP_001128577.1  potassium channel subfamily K member 16 isoform 1

    See identical proteins and their annotated locations for NP_001128577.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as TALK-1c) encodes the longest isoform (1).
    Source sequence(s)
    AL136087, BC111860, BP387644, CA843225
    Consensus CDS
    CCDS47421.1
    UniProtKB/Swiss-Prot
    Q96T55
    Related
    ENSP00000391498.2, ENST00000425054.6
    Conserved Domains (1) summary
    pfam07885
    Location:92148
    Ion_trans_2; Ion channel
  2. NM_001135106.2NP_001128578.1  potassium channel subfamily K member 16 isoform 3

    See identical proteins and their annotated locations for NP_001128578.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as TALK-1b) contains an alternative 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF358909, AL136087, BC111860, CA843225, EU978943
    Consensus CDS
    CCDS47422.1
    UniProtKB/Swiss-Prot
    Q96T55
    Related
    ENSP00000415375.2, ENST00000437525.3
    Conserved Domains (1) summary
    pfam07885
    Location:92148
    Ion_trans_2; Ion channel
  3. NM_001135107.2NP_001128579.1  potassium channel subfamily K member 16 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as TALK-1d) uses a different acceptor splice site at the 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (4) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL136087, BC111860, BP387644, CA843225
    Consensus CDS
    CCDS47420.1
    UniProtKB/Swiss-Prot
    Q96T55
    Related
    ENSP00000362324.4, ENST00000373227.8
    Conserved Domains (1) summary
    pfam07885
    Location:92148
    Ion_trans_2; Ion channel
  4. NM_001363784.1NP_001350713.1  potassium channel subfamily K member 16 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL136087
    Consensus CDS
    CCDS87391.1
    UniProtKB/TrEMBL
    D6RC57
    Related
    ENSP00000423842.1, ENST00000507712.5
    Conserved Domains (1) summary
    pfam07885
    Location:2783
    Ion_trans_2; Ion channel
  5. NM_032115.4NP_115491.1  potassium channel subfamily K member 16 isoform 2

    See identical proteins and their annotated locations for NP_115491.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as TALK-1a) contains an additional coding exon and uses a different acceptor splice site at the 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF358909, AL136087, BC111860, BP387644, CA843225
    Consensus CDS
    CCDS4843.1
    UniProtKB/Swiss-Prot
    Q96T55, Q9H591
    Related
    ENSP00000362326.5, ENST00000373229.9
    Conserved Domains (1) summary
    pfam07885
    Location:92148
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    39314570..39322968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011346.2XP_016866835.1  potassium channel subfamily K member 16 isoform X1

    UniProtKB/Swiss-Prot
    Q96T55
    Conserved Domains (1) summary
    pfam07885
    Location:92148
    Ion_trans_2; Ion channel

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    39139241..39147515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)