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INHBE inhibin subunit beta E [ Homo sapiens (human) ]

Gene ID: 83729, updated on 23-Nov-2023

Summary

Official Symbol
INHBEprovided by HGNC
Official Full Name
inhibin subunit beta Eprovided by HGNC
Primary source
HGNC:HGNC:24029
See related
Ensembl:ENSG00000139269 MIM:612031; AllianceGenome:HGNC:24029
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. This gene may be upregulated under conditions of endoplasmic reticulum stress, and this protein may inhibit cellular proliferation and growth in pancreas and liver. [provided by RefSeq, Sep 2016]
Expression
Restricted expression toward liver (RPKM 43.7) See more
Orthologs
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Genomic context

See INHBE in Genome Data Viewer
Location:
12q13.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (57455307..57458025)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (57423596..57426314)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57849090..57851808)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene R3H domain containing 2 Neighboring gene R3HDM2 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 358 Neighboring gene uncharacterized LOC124902947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6537 Neighboring gene inhibin subunit beta C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:57869684-57870573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6542 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr12:57880828-57881775 and GRCh37_chr12:57881776-57882722 Neighboring gene GLI family zinc finger 1 Neighboring gene Rho GTPase activating protein 9 Neighboring gene methionyl-tRNA synthetase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC4638

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
inhibin beta E chain
Names
activin beta-E chain
inhibin beta E subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031479.5NP_113667.1  inhibin beta E chain preproprotein

    See identical proteins and their annotated locations for NP_113667.1

    Status: REVIEWED

    Source sequence(s)
    AC022506, BC005161, BU632022, DA050178
    Consensus CDS
    CCDS8939.1
    UniProtKB/Swiss-Prot
    P58166
    Related
    ENSP00000266646.2, ENST00000266646.3
    Conserved Domains (1) summary
    pfam00019
    Location:247349
    TGF_beta; Transforming growth factor beta like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    57455307..57458025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    57423596..57426314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)