Inhbe inhibin beta-E [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Inhbeprovided by MGI
Official Full Name: inhibin beta-Eprovided by MGI
Primary source: MGI:MGI:109269
See related: Ensembl:ENSMUSG00000047492 AllianceGenome:MGI:109269
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. This gene may be upregulated under conditions of endoplasmic reticulum stress, and this protein may inhibit cellular proliferation and growth in pancreas and liver. [provided by RefSeq, Sep 2016]
Expression: Biased expression in liver E18 (RPKM 23.1) and liver adult (RPKM 22.2) See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 74.5 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (127185271..127187717, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (127349402..127351848, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification and validation of INHBE and P4HA1 as hub genes in non-alcoholic fatty liver disease.
Title: Identification and validation of INHBE and P4HA1 as hub genes in non-alcoholic fatty liver disease.
a function of activin E to stimulate energy expenditure through brown and beige adipocyte activation, is reported.
Title: Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine.
INHBE functions as a possible hepatokine to alter the whole-body metabolic status under obese insulin-resistant condition
Title: Inhibin βE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples.
Taking these results together, activin E may act as a regulator of the hypothalamic-pituitary-adrenal axis.
Title: Abnormalities in aggression and anxiety in transgenic mice overexpressing activin E.
results indicate that the beta(C) and beta(E) subunits of activin form homo- and heterodimers, and that the functions of the two subunits are quite different
Title: Comparison of the function of the beta(C) and beta(E) subunits of activin in AML12 hepatocytes.
activin E has a role in regulating the proliferation of pancreatic exocrine cells
Title: Impaired growth of pancreatic exocrine cells in transgenic mice expressing human activin betaE subunit.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

Inhbe (e-PCR), detects polymorphism
- UniSTS:496694

PMC86088P1 (e-PCR)
- UniSTS:273517

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: inhibin beta E chain

Names: activin beta-E chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.