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SESN2 sestrin 2 [ Homo sapiens (human) ]

Gene ID: 83667, updated on 12-Jul-2020

Summary

Official Symbol
SESN2provided by HGNC
Official Full Name
sestrin 2provided by HGNC
Primary source
HGNC:HGNC:20746
See related
Ensembl:ENSG00000130766 MIM:607767
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HI95; SES2; SEST2
Summary
This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 15.0), kidney (RPKM 10.3) and 24 other tissues See more
Orthologs

Genomic context

See SESN2 in Genome Data Viewer
Location:
1p35.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (28259452..28282491)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (28585963..28609002)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C8 Neighboring gene ATP synthase inhibitory factor subunit 1 Neighboring gene mediator complex subunit 18 Neighboring gene Sharpr-MPRA regulatory region 70 Neighboring gene phosphatase and actin regulator 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761M0212, DKFZp761M02121

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP-dissociation inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
leucine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leucine binding IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity, acting on peroxide as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidoreductase activity, acting on peroxide as acceptor IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sulfiredoxin activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT sulfiredoxin activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular oxidant detoxification IDA
Inferred from Direct Assay
more info
PubMed 
NOT cellular oxidant detoxification IDA
Inferred from Direct Assay
more info
PubMed 
cellular oxidant detoxification IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to amino acid starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to amino acid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to amino acid stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to glucose starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to leucine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to leucine IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to leucine starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to leucine starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
glucose import IEA
Inferred from Electronic Annotation
more info
 
mitochondrial DNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of translation in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of lipophagy IEA
Inferred from Electronic Annotation
more info
 
positive regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cAMP-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of response to reactive oxygen species IEA
Inferred from Electronic Annotation
more info
 
response to glucose IEA
Inferred from Electronic Annotation
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
triglyceride homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with Atg1/ULK1 kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with GATOR2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with GATOR2 complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with TORC2 complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with nucleotide-activated protein kinase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sestrin-2
Names
hypoxia induced gene 95
hypoxia-induced
NP_113647.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031459.5NP_113647.1  sestrin-2

    See identical proteins and their annotated locations for NP_113647.1

    Status: REVIEWED

    Source sequence(s)
    AK025640, BC013304, DB094914
    Consensus CDS
    CCDS321.1
    UniProtKB/Swiss-Prot
    P58004
    Related
    ENSP00000253063.3, ENST00000253063.4
    Conserved Domains (1) summary
    pfam04636
    Location:43479
    PA26; PA26 p53-induced protein (sestrin)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    28259452..28282491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_946773.1 RNA Sequence

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654706.1 Reference GRCh38.p13 PATCHES

    Range
    53162..76135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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